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Theme: Alzheimer’s Disease - Review

Understanding the relationship between GSK-3 and Alzheimer’s disease: a focus on how GSK-3 can modulate synaptic plasticity processes

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Pages 495-503 | Published online: 09 Jan 2014

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Wei Sun, Zhenzhong Lu, Xiao Chen, Yang, Yazi Mei, Xiaoliang Li & Lei An. (2022) Aluminum Oxide Nanoparticles Impair Working Memory and Neuronal Activity through the GSK3β/BDNF Signaling Pathway of Prefrontal Cortex in Rats. ACS Chemical Neuroscience 13:23, pages 3352-3361.
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M. A Mukhamedyarov, P. N Grigoryev, E. A Ushanova & A. L Zefirov. (2020) Effects of inhibition of glycogen synthase kinase 3p on neuromuscular synaptic transmission in transgenic mice with model of alzheimer's disease. Genes & Cells 15:4, pages 57-60.
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Chao-Chao Yu, Jia Wang, Si-Si Ye, Shan Gao, Jia Li, Li Wang, Tao Jiang, Xue-Song Wang, Bo-Cun Li, Qing Shu, Wei Lu, Yan-Jun Du & Li-Hong Kong. (2020) Preventive Electroacupuncture Ameliorates D-Galactose-Induced Alzheimer’s Disease-Like Pathology and Memory Deficits Probably via Inhibition of GSK3 β /mTOR Signaling Pathway . Evidence-Based Complementary and Alternative Medicine 2020, pages 1-12.
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In Gyoung Ju, Namkwon Kim, Jin Gyu Choi, Jong Kil Lee & Myung Sook Oh. (2019) Cuscutae Japonicae Semen Ameliorates Memory Dysfunction by Rescuing Synaptic Damage in Alzheimer’s Disease Models. Nutrients 11:11, pages 2591.
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Alexey M. Petrov, Natalia Mast, Yong Li & Irina A. Pikuleva. (2019) The key genes, phosphoproteins, processes, and pathways affected by efavirenz‐activated CYP46A1 in the amyloid‐decreasing paradigm of efavirenz treatment. The FASEB Journal 33:8, pages 8782-8798.
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Yingjia Yao, Yameng Wang, Liang Kong, Yuqing Chen & Jingxian Yang. (2019) Osthole decreases tau protein phosphorylation via PI3K/AKT/GSK-3β signaling pathway in Alzheimer's disease. Life Sciences 217, pages 16-24.
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Tobias Engel, Raquel Gómez-Sintes, Mariana Alves, Eva M. Jimenez-Mateos, Marta Fernández-Nogales, Amaya Sanz-Rodriguez, James Morgan, Edward Beamer, Alberto Rodríguez-Matellán, Mark Dunleavy, Takanori Sano, Jesus Avila, Miguel Medina, Felix Hernandez, José J. Lucas & David C. Henshall. (2018) Bi-directional genetic modulation of GSK-3β exacerbates hippocampal neuropathology in experimental status epilepticus. Cell Death & Disease 9:10.
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Yue Cao, Christian Hölscher, Meng-Ming Hu, Ting Wang, Fang Zhao, Yu Bai, Jun Zhang, Mei-Na Wu & Jin-Shun Qi. (2018) DA5-CH, a novel GLP-1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease. European Journal of Pharmacology 827, pages 215-226.
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Yali Zhang, Jiahui Zhang, Enhao Wang, Wei Qian, Yan Fan, Ying Feng, Haimeng Yin, Yang Li, Yuning Wang & Tianli Yuan. (2018) Microcystin-Leucine-Arginine Induces Tau Pathology Through Bα Degradation via Protein Phosphatase 2A Demethylation and Associated Glycogen Synthase Kinase-3β Phosphorylation. Toxicological Sciences 162:2, pages 475-487.
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Bo Liu, Li-Hua Sun, Yan-Fei Huang, Li-Jun Guo & Li-Shu Luo. (2018) Protein phosphatase 2ACα gene knock-out results in cortical atrophy through activating hippo cascade in neuronal progenitor cells. The International Journal of Biochemistry & Cell Biology 95, pages 53-62.
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Zhi-Peng Xu, Guo-Sheng Gan, Yu-Min Liu, Jin-Song Xiao, Han-Xing Liu, Bin Mei & Jun-Jian Zhang. (2017) Adiponectin Attenuates Streptozotocin-Induced Tau Hyperphosphorylation and Cognitive Deficits by Rescuing PI3K/Akt/GSK-3β Pathway. Neurochemical Research 43:2, pages 316-323.
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Sabine Martin, Marcio Lazzarini, Christian Dullin, Saju Balakrishnan, Felipe V. Gomes, Milena Ninkovic, Ahmed El Hady, Luis A. Pardo, Walter Stühmer & Elaine Del-Bel. (2016) SK3 Channel Overexpression in Mice Causes Hippocampal Shrinkage Associated with Cognitive Impairments. Molecular Neurobiology 54:2, pages 1078-1091.
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A. Gamir-Morralla, C. López-Menéndez, M. Medina & T. Iglesias. 2017. Neuroprotection in Alzheimer's Disease. Neuroprotection in Alzheimer's Disease 123 147 .
Susan A. Farr, Karin E. Sandoval, Michael L. Niehoff, Ken A. Witt, Vijaya B. Kumar & John E. Morley. (2016) Peripheral Administration of GSK-3β Antisense Oligonucleotide Improves Learning and Memory in SAMP8 and Tg2576 Mouse Models of Alzheimer’s Disease. Journal of Alzheimer's Disease 54:4, pages 1339-1348.
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Grant P. Otto, Devdutt Sharma & Robin S.B. Williams. (2016) Non-Catalytic Roles of Presenilin Throughout Evolution. Journal of Alzheimer's Disease 52:4, pages 1177-1187.
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Jeremy Koppel, Heidy Jimenez, Leslie Adrien, Blaine S. Greenwald, Philippe Marambaud, Ezra Cinamon & Peter Davies. (2016) Haloperidol inactivates AMPK and reduces tau phosphorylation in a tau mouse model of Alzheimer's disease. Alzheimer's & Dementia: Translational Research & Clinical Interventions 2:2, pages 121-130.
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Chih-Hsin Lin, Yu-Shao Hsieh, Yih-Ru Wu, Chia-Jen Hsu, Hsuan-Chiang Chen, Wun-Han Huang, Kuo-Hsuan Chang, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Ying-Chieh Sun, Guan-Chiun Lee & Guey-Jen Lee-Chen. (2016) Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays. European Journal of Pharmaceutical Sciences 89, pages 11-19.
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Christopher J. Dunning, Gavin McGauran, Katarina Willén, Gunnar K. Gouras, David J. O’Connell & Sara Linse. (2015) Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer’s Disease?. ACS Chemical Neuroscience 7:2, pages 161-170.
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Hao Zhang, Jun Sun, Jing Ye, Usama Ashraf, Zheng Chen, Bibo Zhu, Wen He, Qiuping Xu, Yanming Wei, Huanchun Chen, Zhen F. Fu, Rong Liu & Shengbo Cao. (2015) Quantitative Label-Free Phosphoproteomics Reveals Differentially Regulated Protein Phosphorylation Involved in West Nile Virus-Induced Host Inflammatory Response. Journal of Proteome Research 14:12, pages 5157-5168.
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Federico Scala, Salvatore Fusco, Cristian Ripoli, Roberto Piacentini, Domenica Donatella Li Puma, Matteo Spinelli, Fernanda Laezza, Claudio Grassi & Marcello D'Ascenzo. (2015) Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K+ current inhibition mediated by activation of caspases and GSK-3. Neurobiology of Aging 36:2, pages 886-900.
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Yi-ze Li, Xiao-hong Tang, Chun-yan Wang, Nan Hu, Ke-liang Xie, Hai-yun Wang, Yong-hao Yu & Guo-lin Wang. (2014) Glycogen Synthase Kinase-3β Inhibition Prevents Remifentanil-Induced Postoperative Hyperalgesia via Regulating the Expression and Function of AMPA Receptors. Anesthesia & Analgesia 119:4, pages 978-987.
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Jean-Marie Sontag & Estelle Sontag. (2014) Protein phosphatase 2A dysfunction in Alzheimer’s disease. Frontiers in Molecular Neuroscience 7.
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Gongli Yu, Yu Zheng, Jinlong Wu & Wei-Min Dai. (2013) Increasing appendage diversity on 3,4-dihydro-3-oxo-2H-1,4-benzoxazines via Aphos–Pd(OAc)2-catalyzed Suzuki–Miyaura cross-coupling of aryl chlorides. Tetrahedron 69:48, pages 10488-10496.
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