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Expert Review of Neurotherapeutics Volume 13, 2013 - Issue 6
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Theme: Epilepsy - Review

AMPA receptor inhibitors for the treatment of epilepsy: the role of perampanel

Gaetano Zaccara Unit of Neurology, Department of Medicine, Florence Health Authority, Firenze, Italy. [email protected]; Unit of Neurology, Department of Medicine, Florence Health Authority, Firenze, Italy. [email protected]
,
Fabio Giovannelli Unit of Neurology, Department of Medicine, Florence Health Authority, Firenze, Italy; Unit of Neurology, Department of Medicine, Florence Health Authority, Firenze, Italy
,
Massimo Cincotta Unit of Neurology, Department of Medicine, Florence Health Authority, Firenze, Italy; Unit of Neurology, Department of Medicine, Florence Health Authority, Firenze, Italy
&
Alfonso Iudice Department of Clinical and Experimental Medicine, Section of Neurology, University of Pisa, Pisa, Italy; Department of Clinical and Experimental Medicine, Section of Neurology, University of Pisa, Pisa, Italy
Pages 647-655 | Published online: 09 Jan 2014

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Read on this site (3)

Simona Lattanzi & Pasquale Striano. (2019) The impact of perampanel and targeting AMPA transmission on anti-seizure drug discovery. Expert Opinion on Drug Discovery 14:3, pages 195-197.
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Andreas Schulze-Bonhage. (2015) Perampanel for epilepsy with partial-onset seizures: a pharmacokinetic and pharmacodynamic evaluation. Expert Opinion on Drug Metabolism & Toxicology 11:8, pages 1329-1337.
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Barbara Miziak, Magdalena Chrościńska-Krawczyk, Barbara Błaszczyk, Iwona Radzik & Stanisław J Czuczwar. (2013) Novel approaches to anticonvulsant drug discovery. Expert Opinion on Drug Discovery 8:11, pages 1415-1427.
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Articles from other publishers (14)

Song Ee Youn, Hoon-Chul Kang, Joon Soo Lee, Heung Dong Kim & Se Hee Kim. (2023) Long-term efficacy and safety of adjunctive perampanel in pediatric patients aged 4–19 years with epilepsy: a real-world study. Scientific Reports 13:1.
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Rui Chen, Guofang Xue & Christian Hölscher. (2021) The role of the TNFα-mediated astrocyte signaling pathway in epilepsy. Acta Epileptologica 3:1.
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Ranran Zhang, Shan Qiao, Xiqin Fang, Kemo Wang, Yanting Shi, Qianwen Du, Tingting Yang & Xuewu Liu. (2021) Efficacy and Tolerability of Perampanel as Adjunctive Therapy in Chinese Patients With Focal-Onset Seizures: An Observational, Prospective Study. Frontiers in Neurology 12.
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Nicole I Wolf, Johannes Zschocke, Cornelis Jakobs, Dietz Rating & Georg F Hoffmann. (2018) ATAD1 encephalopathy and stiff baby syndrome: a recognizable clinical presentation. Brain 141:6, pages e49-e49.
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Hirokazu Yamagishi, Hitoshi Osaka, Masako Nagashima, Mari Kuwajima, Akihiko Miyauchi, Takahiro Ikeda, Karin Kojima, Ayumi Matsumoto & Takanori Yamagata. (2018) Efficacy and Side Effect of Perampanel for Refractory Epilepsy. Journal of the Japan Epilepsy Society 35:3, pages 693-701.
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Yanke Zhang, Baobing Gao, Fangshuo Zheng, Shanshan Lu, Yun Li, Yan Xiong, Qin Yang, Yong Yang, Pengfei Fu, Fei Xiao & Xuefeng Wang. (2017) The Phosphodiesterase 10A Inhibitor PF-2545920 Enhances Hippocampal Excitability and Seizure Activity Involving the Upregulation of GluA1 and NR2A in Post-synaptic Densities. Frontiers in Molecular Neuroscience 10.
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Nicole M. Lykens, David J. Coughlin, Jyoti M. Reddi, Gordon J. Lutz & Melanie K. Tallent. (2017) AMPA GluA1-flip targeted oligonucleotide therapy reduces neonatal seizures and hyperexcitability. PLOS ONE 12:2, pages e0171538.
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Pasquale StrianoVincenzo BelcastroAntonietta CoppolaCarlo MinettiSalvatore Striano. (2016) Antiepileptic Drugs Under Investigation for Treatment of Focal Epilepsy. Clinical Neuropharmacology 39:6, pages 281-287.
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Lubos Remen, Olivier Bezençon, Lloyd Simons, Rick Gaston, Dennis Downing, John Gatfield, Catherine Roch, Melanie Kessler, Johannes Mosbacher, Thomas Pfeifer, Corinna Grisostomi, Markus Rey, Eric A. Ertel & Richard Moon. (2016) Preparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T-Type Calcium Channel Blockers. Journal of Medicinal Chemistry 59:18, pages 8398-8411.
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Leslie A Rudzinski, Naymeé J Vélez-Ruiz, Evan R Gedzelman, Elizabeth A Mauricio, Jerry J Shih & Ioannis Karakis. (2023) New Antiepileptic Drugs: Focus on Ezogabine, Clobazam, and Perampanel. Journal of Investigative Medicine 64:6, pages 1087-1101.
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Gaetano Zaccara & Dieter Schmidt. (2016) Do traditional anti-seizure drugs have a future? A review of potential anti-seizure drugs in clinical development. Pharmacological Research 104, pages 38-48.
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Gaetano Zaccara & Piero Perucca. 2015. The Treatment of Epilepsy. The Treatment of Epilepsy 275 287 .
Gaetano Zaccara & Emilio Perucca. (2015) Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs. Epileptic Disorders 16:4, pages 409-431.
Crossref
R. Zwart, E. Sher, X. Ping, X. Jin, J. R. SimsJr.Jr., A. S. Chappell, S. D. Gleason, P. J. Hahn, K. Gardinier, D. L. Gernert, J. Hobbs, J. L. Smith, S. N. Valli & J. M. Witkin. (2014) Perampanel, an Antagonist of α -Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptors, for the Treatment of Epilepsy: Studies in Human Epileptic Brain and Nonepileptic Brain and in Rodent Models . Journal of Pharmacology and Experimental Therapeutics 351:1, pages 124-133.
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