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Drug Profile

Ginsenoside Rd for acute ischemic stroke: translating from bench to bedside

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Pages 603-613 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Li Feng, Chunchun Xu, Zhuo Li, Jing Li, Yulin Dai, Hongxiang Han, Shanshan Yu & Shuying Liu. (2016) Microbial conversion of ginsenoside Rd from Rb1 by the fungus mutant Aspergillus niger strain TH-10a. Preparative Biochemistry & Biotechnology 46:4, pages 336-341.
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Lili Xu, Ruibing Guo, Yi Xie, Minmin Ma, Ruidong Ye & Xinfeng Liu. (2015) Caveolae: molecular insights and therapeutic targets for stroke. Expert Opinion on Therapeutic Targets 19:5, pages 633-650.
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Craig J Smith, Adam Denes, Pippa J Tyrrell & Mario Di Napoli. (2015) Phase II anti-inflammatory and immune-modulating drugs for acute ischaemic stroke. Expert Opinion on Investigational Drugs 24:5, pages 623-643.
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Articles from other publishers (28)

Xue-min Chen, Yu-hui Liu, Shuai-fei Ji, Xin-miao Xue, Lin-lin Wang, Min Zhang, Yao-ming Chang & Xiao-cheng Wang. (2022) Protective effect of ginsenoside Rd on military aviation noise-induced cochlear hair cell damage in guinea pigs. Environmental Science and Pollution Research 30:9, pages 23965-23981.
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Suping Li, Nengwei Yu, Fei Xu, Liang Yu, Qian Yu & Jing Fu. (2022) Ginsenoside Rd protects cerebral endothelial cells from oxygen-glucose deprivation/reoxygenation induced pyroptosis via inhibiting SLC5A1 mediated sodium influx. Journal of Ginseng Research 46:5, pages 700-709.
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Kai Tang, Weiwei Qin, Rongyun Wei, Yeying Jiang, Lingling Fan, Zhen Wang & Ninghua Tan. (2022) Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence. Pharmacological Research 179, pages 106123.
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Xiaoping Song, Lina Wang & Daidi Fan. (2022) Insights into Recent Studies on Biotransformation and Pharmacological Activities of Ginsenoside Rd. Biomolecules 12:4, pages 512.
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Jewook Choi, Jaewoo Kim, Hyo In Yoon & Jung Eek Son. (2022) Effect of far-red and UV-B light on the growth and ginsenoside content of ginseng (Panax ginseng C. A. Meyer) sprouts aeroponically grown in plant factories. Horticulture, Environment, and Biotechnology 63:1, pages 77-87.
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Eun Namgung, Jungyoon Kim, Hyeonseok Jeong, Gahae Hong, Myeongju Kim, Rye Young Kim, Shinhye Kim & In Kyoon Lyoo. (2020) Effects of Korean red ginseng on human gray matter volume and cognitive function: A voxel‐based morphometry study. Human Psychopharmacology: Clinical and Experimental 36:2.
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Chen Zhang, Xuedong Liu, Hui Xu, Gengyao Hu, Xiao Zhang, Zhen Xie, Dongyun Feng, Rui Wu, Gang Zhao & Ming Shi. (2020) Protopanaxadiol ginsenoside Rd protects against NMDA receptor-mediated excitotoxicity by attenuating calcineurin-regulated DAPK1 activity. Scientific Reports 10:1.
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Bei Zhang, KathrynE Saatman & Lei Chen. (2020) Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke. Neural Regeneration Research 15:3, pages 416.
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C.C. Barbosa, T.C. Rodrigues, C.F.S. Ataídes, M.L. Santos, P.C. Ghedini, W. Dias Junior, M.L. Andersen & R. Mazaro-Costa. (2019) Protective effects of Hydrocotyle umbellata var. bonariensis Lam. (Araliaceae) on memory in sleep-impaired female mice. Journal of Ethnopharmacology 245, pages 112183.
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Fang Li, Li-Zhi Pang, Ling Zhang, Yu Zhang, Yuan-Yuan Zhang, Bo-Yang Yu & Jun-Ping Kou. (2019) YiQiFuMai powder injection ameliorates chronic heart failure through cross-talk between adipose tissue and cardiomyocytes via up-regulation of circulating adipokine omentin. Biomedicine & Pharmacotherapy 119, pages 109418.
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Xuejia Shi, Jin Xu, Changning Lu, Zhenzhong Wang, Wei Xiao & Linguo Zhao. (2019) Immobilization of high temperature-resistant GH3 β-glucosidase on a magnetic particle Fe3O4-SiO2-NH2-Cellu-ZIF8/zeolitic imidazolate framework. Enzyme and Microbial Technology 129, pages 109347.
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Lei Liu, Gigi A. Anderson, Tyler G. Fernandez & Sylvain Doré. (2019) Efficacy and Mechanism of Panax Ginseng in Experimental Stroke. Frontiers in Neuroscience 13.
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Dongxu Zhao, Minglei Zhang, Hongping Yuan, Chunyang Meng, Boyin Zhang & Han Wu. (2018) Ginsenoside Rb1 protects against spinal cord ischemia-reperfusion injury in rats by downregulating the Bax/Bcl-2 ratio and caspase-3 and p-Ask-1 levels. Experimental and Molecular Pathology 105:3, pages 229-235.
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Dezhi Kong, Xiaolin Tian, Yunshan Li, Saihang Zhang, Yiru Cheng, Lifang Huo, Huanhuan Ma, Zuxiao Yang, Leiming Ren, Mingquan Zhang & Wei Zhang. (2018) Revealing the Inhibitory Effect of Ginseng on Mitochondrial Respiration through Synaptosomal Proteomics. PROTEOMICS 18:11, pages 1700354.
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Gerburg Keilhoff, Torben Esser, Maximilian Titze, Uwe Ebmeyer & Lorenz Schild. (2017) Gynostemma�pentaphyllum is neuroprotective in a rat model of cardiopulmonary resuscitation. Experimental and Therapeutic Medicine.
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Yanyan Wang, Yu Ren, Leilei Xing, Xiangdong Dai, Sheng Liu, Bin Yu & Yi Wang. (2016) Endothelium-dependent vasodilation effects of Panax notoginseng and its main components are mediated by nitric oxide and cyclooxygenase pathways. Experimental and Therapeutic Medicine 12:6, pages 3998-4006.
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Lin Cong & Wenting Chen. (2016) Neuroprotective Effect of Ginsenoside Rd in Spinal Cord Injury Rats. Basic & Clinical Pharmacology & Toxicology 119:2, pages 193-201.
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Sang Il Gum, Md Khalilur Rahman, Jong Soon Won & Min Kyung Cho. (2016) A Distinctive Pattern of Beauveria bassiana -biotransformed Ginsenoside Products Triggers Mitochondria/FasL-mediated Apoptosis in Colon Cancer Cells . Phytotherapy Research 30:1, pages 136-143.
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Marc R. Del Bigio & Domenico L. Di Curzio. (2016) Nonsurgical therapy for hydrocephalus: a comprehensive and critical review. Fluids and Barriers of the CNS 13:1.
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Seockmo Ku, Hyun Ju You, Myeong Soo Park & Geun Eog Ji. (2015) Effects of ascorbic acid on α-l-arabinofuranosidase and α-l-arabinopyranosidase activities from Bifidobacterium longum RD47 and its application to whole cell bioconversion of ginsenoside. Journal of the Korean Society for Applied Biological Chemistry 58:6, pages 857-865.
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Cheng Lu, Zhijun Sun & Line Wang. (2015) Inhibition of L-type Ca2+ current by ginsenoside Rd in rat ventricular myocytes. Journal of Ginseng Research 39:2, pages 169-177.
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Elena González-Burgos, Carlos Fernandez-Moriano & M. Pilar Gómez-Serranillos. (2014) Potential Neuroprotective Activity of Ginseng in Parkinson’s Disease: A Review. Journal of Neuroimmune Pharmacology 10:1, pages 14-29.
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Kang An, Zhang Shengjie, Shan Jinjun & Di Liuqing. (2015) Gut microbiota-mediated deglycosylation of ginsenoside Rb 1 in rats: in vitro and in vivo insights from quantitative ultra-performance liquid chromatography-mass spectrometry analysis . Analytical Methods 7:15, pages 6173-6181.
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Xiao Zhang, Ming Shi, Ruidong Ye, Wei Wang, Xuedong Liu, Guangyun Zhang, Junliang Han, Yunxia Zhang, Bing Wang, Jun Zhao, Juan Hui, Lize Xiong & Gang Zhao. (2014) Ginsenoside Rd Attenuates Tau Protein Phosphorylation Via the PI3K/AKT/GSK-3β Pathway After Transient Forebrain Ischemia. Neurochemical Research 39:7, pages 1363-1373.
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Jin-Song Zhou, Jiang-Feng Wang, Bao-Rong He, Yong-Sheng Cui, Xiang-Yi Fang, Jian-Long Ni, Jie Chen & Kun-Zheng Wang. (2014) Ginsenoside Rd Attenuates Mitochondrial Permeability Transition and Cytochrome c Release in Isolated Spinal Cord Mitochondria: Involvement of Kinase-Mediated Pathways. International Journal of Molecular Sciences 15:6, pages 9859-9877.
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Xinfeng Liu, Ruidong Ye, Tao Yan, Shan Ping Yu, Ling Wei, Gelin Xu, Xinying Fan, Yongjun Jiang, R. Anne Stetler, George Liu & Jieli Chen. (2014) Cell based therapies for ischemic stroke: From basic science to bedside. Progress in Neurobiology 115, pages 92-115.
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Jackalina M. Van Kampen, David B. Baranowski, Christopher A. Shaw & Denis G. Kay. (2014) Panax ginseng is neuroprotective in a novel progressive model of Parkinson's disease. Experimental Gerontology 50, pages 95-105.
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Zhixin Huang, Qin Yin, Wen Sun, Wusheng Zhu, Yongkun Li, Wenhua Liu, Lulu Xiao, Zuowei Duan, Qiankun Cai, Dezhi Liu, Minmin Ma & Xinfeng Liu. (2013) Microbleeds in ischemic stroke are associated with lower serum adiponectin and higher soluble E-selectin levels. Journal of the Neurological Sciences 334:1-2, pages 83-87.
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