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Review

Plant glycans: friend or foe in vaccine development?

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Pages 835-842 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Sergio Rosales-Mendoza, Karla I. Solís-Andrade, Verónica A. Márquez-Escobar, Omar González-Ortega & Bernardo Bañuelos-Hernandez. (2020) Current advances in the algae-made biopharmaceuticals field. Expert Opinion on Biological Therapy 20:7, pages 751-766.
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Sergio Rosales-Mendoza, Regina Ríos-Huerta & Carlos Angulo. (2015) An overview of tuberculosis plant-derived vaccines. Expert Review of Vaccines 14:6, pages 877-889.
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Sergio Rosales-Mendoza & Jorge A Salazar-González. (2014) Immunological aspects of using plant cells as delivery vehicles for oral vaccines. Expert Review of Vaccines 13:6, pages 737-749.
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Sergio Rosales-Mendoza, Lucía Orellana-Escobedo, Andrea Romero-Maldonado, Eva L Decker & Ralf Reski. (2014) The potential of Physcomitrella patens as a platform for the production of plant-based vaccines. Expert Review of Vaccines 13:2, pages 203-212.
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Franco M Buonaguro & John-Edward Butler-Ransohoff. (2010) PharmaPlant: the new frontier in vaccines. Expert Review of Vaccines 9:8, pages 805-807.
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Ana‐Maria Pantazica, André van Eerde, Mihaela‐Olivia Dobrica, Iuliana Caras, Irina Ionescu, Adriana Costache, Catalin Tucureanu, Hege Steen, Catalin Lazar, Inger Heldal, Sissel Haugslien, Adrian Onu, Crina Stavaru, Norica Branza‐Nichita & Jihong Liu Clarke. (2023) The “humanized” N‐glycosylation pathway in CRISPR /Cas9‐edited Nicotiana benthamiana significantly enhances the immunogenicity of a S/ preS1 Hepatitis B Virus antigen and the virus‐neutralizing antibody response in vaccinated mice . Plant Biotechnology Journal 21:6, pages 1176-1190.
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Pankaj Kumar Paradia, Rameshwar Bhavale, Tejas Agnihotri & Aakanchha Jain. (2023) A Review on Edible Vaccines and Biopharmaceutical Products from Plants. Current Pharmaceutical Biotechnology 24:4, pages 495-509.
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Madhu, Alok Sharma, Amandeep Kaur, Deepika Antil, Sudhir P. Singh & Santosh Kumar Upadhyay. 2023. Plants as Bioreactors for Industrial Molecules. Plants as Bioreactors for Industrial Molecules 1 27 .
Khadijeh Ghasemian, Inge Broer, Jennifer Schön, Nadine Kolp, Richard Killisch & Jana Huckauf. (2023) Plant-Produced Mouse-Specific Zona Pellucida 3 Peptide Induces Immune Responses in Mice. Vaccines 11:1, pages 153.
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Benita Ortega-Berlanga & Tomasz Pniewski. 2023. Tools & Techniques of Plant Molecular Farming. Tools & Techniques of Plant Molecular Farming 35 61 .
Vijay Kant Pandey, Rajani Sharma, Gopal Kumar Prajapati, Tapan Kumar Mohanta & Awdhesh Kumar Mishra. (2022) N-glycosylation, a leading role in viral infection and immunity development. Molecular Biology Reports 49:8, pages 8109-8120.
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Bhavika Gupta, Daizy Sadaria, Vaishnavi U. Warrier, Anuradha Kirtonia, Ravi Kant, Amit Awasthi, Prakash Baligar, Jayanta K. Pal, Eiji Yuba, Gautam Sethi, Manoj Garg & Rajesh Kumar Gupta. (2022) Plant lectins and their usage in preparing targeted nanovaccines for cancer immunotherapy. Seminars in Cancer Biology 80, pages 87-106.
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Alicia K. Aquino, Zachary A. Manzer, Susan Daniel & Matthew P. DeLisa. (2021) Glycosylation-on-a-Chip: A Flow-Based Microfluidic System for Cell-Free Glycoprotein Biosynthesis. Frontiers in Molecular Biosciences 8.
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Puna Maya Maharjan & Sunghwa Choe. (2021) Plant-Based COVID-19 Vaccines: Current Status, Design, and Development Strategies of Candidate Vaccines. Vaccines 9:9, pages 992.
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Raquel Cid & Jorge Bolívar. (2021) Platforms for Production of Protein-Based Vaccines: From Classical to Next-Generation Strategies. Biomolecules 11:8, pages 1072.
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Neda Rahimian, Hamid Reza Miraei, Atefeh Amiri, Mohammad Saeid Ebrahimi, Javid Sadri Nahand, Hossein Tarrahimofrad, Michael R. Hamblin, Haroon Khan & Hamed Mirzaei. (2021) Plant-based vaccines and cancer therapy: Where are we now and where are we going?. Pharmacological Research 169, pages 105655.
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S. Aswini, E. Sanmuga Priya & P. Senthamil Selvan. (2021) Book review. Bioactive Carbohydrates and Dietary Fibre 25, pages 100244.
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Se Hee Park, Kon-Young Ji, Hyun Min Kim, Sang Hoon Ma, Seo Young Park, Ju Hui Do, Doo-Byoung Oh, Hyung Sik Kang, Jae Sung Shim & Young Hee Joung. (2021) Optimization of the human colorectal carcinoma antigen GA733-2 production in tobacco plants. Plant Biotechnology Reports 15:1, pages 55-67.
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Ryo Misaki, Kazuhito Fujiyama & Hiroyuki Kajiura. 2021. Comprehensive Glycoscience. Comprehensive Glycoscience 93 109 .
Emmanuel Margolin, Max Crispin, Ann Meyers, Ros Chapman & Edward P. Rybicki. (2020) A Roadmap for the Molecular Farming of Viral Glycoprotein Vaccines: Engineering Glycosylation and Glycosylation-Directed Folding. Frontiers in Plant Science 11.
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Joachim Steen Larsen, Richard Torbjörn Gustav Karlsson, Weihua Tian, Morten Alder Schulz, Annemarie Matthes, Henrik Clausen, Bent Larsen Petersen & Zhang Yang. (2020) Engineering mammalian cells to produce plant-specific N-glycosylation on proteins. Glycobiology 30:8, pages 528-538.
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Emmanuel Margolin, Rosamund Chapman, Ann E. Meyers, Michiel T. van Diepen, Phindile Ximba, Tandile Hermanus, Carol Crowther, Brandon Weber, Lynn Morris, Anna-Lise Williamson & Edward P. Rybicki. (2019) Production and Immunogenicity of Soluble Plant-Produced HIV-1 Subtype C Envelope gp140 Immunogens. Frontiers in Plant Science 10.
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Nicolas Smargiasso, Joseph Nader, Stéphane Rioux, Gabriel Mazzucchelli, Marc Boutry, Edwin De Pauw, François Chaumont & Catherine Navarre. (2019) Exploring the N-Glycosylation Profile of Glycoprotein B from Human Cytomegalovirus Expressed in CHO and Nicotiana tabacum BY-2 Cells. International Journal of Molecular Sciences 20:15, pages 3741.
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Joseph G.L. Hunter, Shyra Wilde, Amanda M. Tafoya, Jamie Horsman, Miranda Yousif, Andrew G. Diamos, Kenneth L. Roland & Hugh S. Mason. (2019) Evaluation of a toxoid fusion protein vaccine produced in plants to protect poultry against necrotic enteritis. PeerJ 7, pages e6600.
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Ayyagari Archana, Lakshna Mahajan, Safikur Rahman & Rinki Minakshi. 2019. Protein Modificomics. Protein Modificomics 145 169 .
Emmanuel Margolin, Ros Chapman, Anna-Lise Williamson, Edward P. Rybicki & Ann E. Meyers. (2018) Production of complex viral glycoproteins in plants as vaccine immunogens. Plant Biotechnology Journal 16:9, pages 1531-1545.
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Verónica Araceli Márquez-Escobar, Bernardo Bañuelos-Hernández & Sergio Rosales-Mendoza. (2018) Expression of a Zika virus antigen in microalgae: Towards mucosal vaccine development. Journal of Biotechnology 282, pages 86-91.
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Sumira Jan & Nazia Abbas. 2018. Himalayan Phytochemicals. Himalayan Phytochemicals 167 215 .
Sergio Rosales-Mendoza, Ricardo Nieto-Gómez & Carlos Angulo. (2017) A Perspective on the Development of Plant-Made Vaccines in the Fight against Ebola Virus. Frontiers in Immunology 8.
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Matilde Merlin, Mario Pezzotti & Linda Avesani. (2017) Edible plants for oral delivery of biopharmaceuticals. British Journal of Clinical Pharmacology 83:1, pages 71-81.
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Luisa M. Madeira, Tim H. Szeto, Maurice Henquet, Nicole Raven, John Runions, Jon Huddleston, Ian Garrard, Pascal M.W. Drake & Julian K-C. Ma. (2016) High-yield production of a human monoclonal IgG by rhizosecretion in hydroponic tobacco cultures. Plant Biotechnology Journal 14:2, pages 615-624.
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Sergio Rosales-Mendoza, Carlos Angulo & Beatriz Meza. (2016) Food-Grade Organisms as Vaccine Biofactories and Oral Delivery Vehicles. Trends in Biotechnology 34:2, pages 124-136.
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S. V. Gerasimova, O. G. Smirnova, A. V. Kochetov & V. K. Shumnyi. (2016) Production of recombinant proteins in plant cells. Russian Journal of Plant Physiology 63:1, pages 26-37.
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Sergio Rosales-MendozaSergio Rosales-Mendoza. 2016. Algae-Based Biopharmaceuticals. Algae-Based Biopharmaceuticals 143 163 .
Margarita Juárez-Montiel, Andrea Romero-Maldonado, Elizabeth Monreal-Escalante, Alicia Becerra-Flora, Schuyler S. Korban, Sergio Rosales-Mendoza & Juan Francisco Jiménez-Bremont. (2015) The Corn Smut (‘Huitlacoche’) as a New Platform for Oral Vaccines. PLOS ONE 10:7, pages e0133535.
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Ana S. Pérez-Martínez, Sergio A. Acevedo-Padilla, Martha Bibbins-Martínez, Jenifer Galván-Alonso & Sergio Rosales-Mendoza. (2015) A perspective on the use of Pleurotus for the development of convenient fungi-made oral subunit vaccines. Vaccine 33:1, pages 25-33.
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Jae Yong Yoo, Ki Seong Ko, Sang Yeol Lee & Kyun Oh Lee. (2014) Glycoengineering in plants for the development of N-glycan structures compatible with biopharmaceuticals. Plant Biotechnology Reports 8:5, pages 357-376.
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Dean F. Bushey, Gary A. Bannon, Bryan F. Delaney, Gerson Graser, Mary Hefford, Xiaoxu Jiang, Thomas C. Lee, Krishna M. Madduri, Michael Pariza, Laura S. Privalle, Rakesh Ranjan, Gloria Saab-Rincon, Barry W. Schafer, Jay J. Thelen, John X.Q. Zhang & Marc S. Harper. (2014) Characteristics and safety assessment of intractable proteins in genetically modified crops. Regulatory Toxicology and Pharmacology 69:2, pages 154-170.
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Mohammad Javad Motamedi, Jafar Amani, Shahla Shahsavandi & Ali Hatef Salmanian. (2013) In Silico Design of Multimeric HN-F Antigen as a Highly Immunogenic Peptide Vaccine Against Newcastle Disease Virus. International Journal of Peptide Research and Therapeutics 20:2, pages 179-194.
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Eva StogerRainer FischerMaurice MoloneyJulian K.-C. Ma. (2014) Plant Molecular Pharming for the Treatment of Chronic and Infectious Diseases. Annual Review of Plant Biology 65:1, pages 743-768.
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Brad Bendiak. 2014. Handbook of Glycosyltransferases and Related Genes. Handbook of Glycosyltransferases and Related Genes 195 207 .
V. Rajan. 2014. Commercial Plant-Produced Recombinant Protein Products. Commercial Plant-Produced Recombinant Protein Products 135 152 .
Sergio Rosales-Mendoza, Dania O. Govea-Alonso, Jorge A. Salazar-González & Schuyler S. Korban. 2014. Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases. Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases 161 173 .
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Yoshikazu Yuki, Mio Mejima, Shiho Kurokawa, Tomoko Hiroiwa, Yuko Takahashi, Daisuke Tokuhara, Tomonori Nochi, Yuko Katakai, Masaharu Kuroda, Natsumi Takeyama, Koji Kashima, Michiyo Abe, Yingju Chen, Ushio Nakanishi, Takehiro Masumura, Yoji Takeuchi, Hiroko Kozuka-Hata, Hiroaki Shibata, Masaaki Oyama, Kunisuke Tanaka & Hiroshi Kiyono. (2013) Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification. Plant Biotechnology Journal 11:7, pages 799-808.
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Sunny Kumar & Hemachand Tummala. (2013) Development of Soluble Inulin Microparticles as a Potent and Safe Vaccine Adjuvant and Delivery System. Molecular Pharmaceutics 10:5, pages 1845-1853.
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Anne-Cécile V. Bayne, David Boltz, Carole Owen, Yelena Betz, Goncalo Maia, Parastoo Azadi, Stephanie Archer-Hartmann, Ross Zirkle & J. Casey Lippmeier. (2013) Vaccination against Influenza with Recombinant Hemagglutinin Expressed by Schizochytrium sp. Confers Protective Immunity. PLoS ONE 8:4, pages e61790.
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