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Review

Confronting the barriers to develop novel vaccines against brucellosis

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Pages 1291-1305 | Published online: 09 Jan 2014

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Jing Huang, Yan Guo, Shujuan Yu, Dongshu Wang, Shulei Li, Jun Wu, Peng Sun, Li Zhu, Hengliang Wang & Chao Pan. (2023) One-step preparation of a self-assembled bioconjugate nanovaccine against Brucella. Virulence 14:1.
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Somayyeh Rahimnahal, Shahnaz Yousefizadeh & Yahya Mohammadi. (2023) Novel multi-epitope vaccine against bovine brucellosis: approach from immunoinformatics to expression. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-25.
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Jing Huang, Yufei Wang, Kangfeng Wang, Shulei Li, Peng Sun, Yan Guo, Jiankai Liu, Ruifu Yang, Ming Zeng, Chao Pan, Hengliang Wang & Li Zhu. (2023) Biosynthesis and Immunological Evaluation of a Dual-Antigen Nanoconjugate Vaccine against Brucella melitensis. Engineering.
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Hossein Tarrahimofrad, Javad Zamani, Michael R. Hamblin, Maryam Darvish & Hamed Mirzaei. (2022) A designed peptide-based vaccine to combat Brucella melitensis, B. suis and B. abortus: Harnessing an epitope mapping and immunoinformatics approach. Biomedicine & Pharmacotherapy 155, pages 113557.
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María Celeste Moran, María Paula Dominguez, Angel Ricardo Bence, Marcelo Gastón Rodriguez, Fernando Alberto Goldbaum, Vanesa Zylberman, Pardo Romina Paola, Giuliana Lupi, Ivan Sergio Marcipar, Claudia María Lützelschwab & Silvia Marcela Estein. (2022) Evaluation of the efficacy of polymeric antigen BLSOmp31 formulated in a new cage-like particle adjuvant (ISPA) administered by parenteral or mucosal routes against Brucella ovis in BALB/c mice. Research in Veterinary Science 145, pages 29-39.
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Zhimin Cheng, Zichen Li, Yi Yin, Zhengmin Lian, Hosny Ahmed Abdelgawad, Hai Hu, Xiang Guan, Dong Zuo, Yumei Cai, Chan Ding, Shaohui Wang, Tao Li, Jingjing Qi, Mingxing Tian & Shengqing Yu. (2021) Characteristics of Brucella abortus vaccine strain A19 reveals its potential mechanism of attenuated virulence. Veterinary Microbiology 254, pages 109007.
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María Celeste Moran, Angel Ricardo Bence, María Fernanda Sánchez Vallecillo, Claudia María Lützelschwab, Marcelo Gastón Rodriguez, Romina Pardo, Fernando Alberto Goldbaum, Vanesa Zylberman, Santiago Daniel Palma, Belkys Angélica Maletto & Silvia Marcela Estein. (2021) Polymeric antigen BLSOmp31 formulated with class B CpG-ODN in a nanostructure (BLSOmp31/CpG-ODN/Coa-ASC16) administered by parenteral or mucosal routes confers protection against Brucella ovis in Balb/c mice. Research in Veterinary Science 135, pages 217-227.
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Erika S. Guimarães, Jéssica M. Martins, Marco Túlio R. Gomes, Daiane M. Cerqueira & Sergio C. Oliveira. (2020) Lack of Interleukin-6 Affects IFN-γ and TNF-α Production and Early In Vivo Control of Brucella abortus Infection. Pathogens 9:12, pages 1040.
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Lidia Szulc-Dąbrowska, Magdalena Bossowska-Nowicka, Justyna Struzik & Felix N. Toka. (2020) Cathepsins in Bacteria-Macrophage Interaction: Defenders or Victims of Circumstance?. Frontiers in Cellular and Infection Microbiology 10.
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A. A. Maruf, F. Yasmin, F. Yeasmin, A K M Anisur Rahman, M. M. Hossain, H. Neubauer & M. S. Rahman. (2019) COMPARISON OF HUMORAL IMMUNE RESPONSES BETWEEN HEAT-INACTIVATED BRUCELLA ABORTUS BIOVAR 3 AND STRAIN RB51 VACCINES IN INDIGENOUS CATTLE OF BANGLADESH. Journal of Veterinary Medical and One Health Research 1:2, pages 247-259.
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Ramin Bagheri Nejad, Ramak Yahyaraeyat, Ali Es‐haghi, Bahar Nayeri Fasaei & Taghi Zahraei Salehi. (2019) Induction of specific cell‐mediated immune responses and protection in BALB/c mice by vaccination with outer membrane vesicles from a Brucella melitensis human isolate . APMIS 127:12, pages 797-804.
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Rongjiong Zheng, Songsong Xie, Qiong Zhang, Ling Cao, Shaniya Niyazi, Xiaobo Lu, Lihua Sun, Yan Zhou, Yuexin Zhang & Kai Wang. (2019) Circulating Th1, Th2, Th17, Treg, and PD-1 Levels in Patients with Brucellosis. Journal of Immunology Research 2019, pages 1-15.
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Faramarz Masjedian Jezi, Shabnam Razavi, Reza Mirnejad & Khosrow Zamani. (2019) Immunogenic and protective antigens of Brucella as vaccine candidates. Comparative Immunology, Microbiology and Infectious Diseases 65, pages 29-36.
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Huanhuan Hou, Xiaofeng Liu & Qisheng Peng. (2019) The advances in brucellosis vaccines. Vaccine 37:30, pages 3981-3988.
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Priscila Carneiro Campos, Marco Túlio Ribeiro Gomes, Fábio Antônio Vitarelli Marinho, Erika Sousa Guimarães, Mariza Gabriela Faleiro de Moura Lodi Cruz & Sergio Costa Oliveira. (2019) Brucella abortus nitric oxide metabolite regulates inflammasome activation and IL‐1β secretion in murine macrophages . European Journal of Immunology 49:7, pages 1023-1037.
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Xiaohong Xu, Zhuang Ding, Jindou Li, Jiaming Liang, Zhaoyang Bu, Jiaxin Ding, Yanling Yang, Xulong Lang, Xinglong Wang, Renfu Yin & Jing Qian. (2019) Newcastle disease virus-like particles containing the Brucella BCSP31 protein induce dendritic cell activation and protect mice against virulent Brucella challenge. Veterinary Microbiology 229, pages 39-47.
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Arnaud Machelart, Georges Potemberg, Laurye Van Maele, Aurore Demars, Maxime Lagneaux, Carl De Trez, Catherine Sabatel, Fabrice Bureau, Sofie De Prins, Pauline Percier, Olivier Denis, Fabienne Jurion, Marta Romano, Jean-Marie Vanderwinden, Jean-Jacques Letesson & Eric Muraille. (2018) Allergic Asthma Favors Brucella Growth in the Lungs of Infected Mice. Frontiers in Immunology 9.
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David R. Bundle & John McGiven. (2017) Brucellosis: Improved Diagnostics and Vaccine Insights from Synthetic Glycans. Accounts of Chemical Research 50:12, pages 2958-2967.
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Arnaud Machelart, Margaux Van Vyve, Georges Potemberg, Aurore Demars, Carl De Trez, Hermann Giresse Tima, Gilles Vanwalleghem, Marta Romano, Carine Truyens, Jean-Jacques Letesson & Eric Muraille. (2017) Trypanosoma Infection Favors Brucella Elimination via IL-12/IFNγ-Dependent Pathways. Frontiers in Immunology 8.
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Mahdiye Saadi, Ahmad Karkhah & Hamid Reza Nouri. (2017) Development of a multi-epitope peptide vaccine inducing robust T cell responses against brucellosis using immunoinformatics based approaches. Infection, Genetics and Evolution 51, pages 227-234.
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Satadru Sekhar Mandal, Lucy Duncombe, N. Vijaya Ganesh, Susmita Sarkar, Laurence Howells, Philip J. Hogarth, David R. Bundle & John McGiven. (2017) Novel Solutions for Vaccines and Diagnostics To Combat Brucellosis. ACS Central Science 3:3, pages 224-231.
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Christopher J. Martin, Aletheia S. Donahue & John D. Meyer. 2016. Physical and Biological Hazards of the Workplace. Physical and Biological Hazards of the Workplace 347 410 .
Zhi-Qiang Du, Xin Li & Jian-Ying Wang. (2016) Immunogenicity Analysis of a Novel Subunit Vaccine Candidate Molecule—Recombinant L7/L12 Ribosomal Protein of Brucella suis. Applied Biochemistry and Biotechnology 179:8, pages 1445-1455.
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Quang Lam Truong, Youngjae Cho, Soyeon Park, Bo-Kyoung Park & Tae-Wook Hahn. (2016) Brucella abortus mutants lacking ATP-binding cassette transporter proteins are highly attenuated in virulence and confer protective immunity against virulent B. abortus challenge in BALB/c mice. Microbial Pathogenesis 95, pages 175-185.
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Delphine Hanot Mambres, Arnaud Machelart, Georges Potemberg, Carl De Trez, Bernhard Ryffel, Jean-Jacques Letesson & Eric Muraille. (2016) Identification of Immune Effectors Essential to the Control of Primary and Secondary Intranasal Infection with Brucella melitensis in Mice . The Journal of Immunology 196:9, pages 3780-3793.
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Alejandra Graciela Díaz, Daniela Alejandra Quinteros, Juan Manuel Llabot, Santiago Daniel Palma, Daniel Alberto Allemandi, Giselle Ghersi, Vanesa Zylberman, Fernando Alberto Goldbaum & Silvia Marcela Estein. (2016) Spray dried microspheres based on chitosan: A promising new carrier for intranasal administration of polymeric antigen BLSOmp31 for prevention of ovine brucellosis. Materials Science and Engineering: C 62, pages 489-496.
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Quang Lam Truong, Youngjae Cho, Soyeon Park, Kiju Kim & Tae-Wook Hahn. (2016) Brucella abortusΔcydCΔcydD and ΔcydCΔpurD double-mutants are highly attenuated and confer long-term protective immunity against virulent Brucella abortus. Vaccine 34:2, pages 237-244.
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Marina Durward-Diioia, Jerome Harms, Mike Khan, Cherisse Hall, Judith A. Smith & Gary A. Splitter. (2015) CD8 + T Cell Exhaustion, Suppressed Gamma Interferon Production, and Delayed Memory Response Induced by Chronic Brucella melitensis Infection . Infection and Immunity 83:12, pages 4759-4771.
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Delphine Hanot Mambres, Arnaud Machelart, Jean-Marie Vanderwinden, Carl De Trez, Bernhard Ryffel, Jean-Jacques Letesson & Eric Muraille. (2015) In Situ Characterization of Splenic Brucella melitensis Reservoir Cells during the Chronic Phase of Infection in Susceptible Mice. PLOS ONE 10:9, pages e0137835.
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Morteza Abkar, Jafar Amani, Abbas Sahebghadam Lotfi, Gholamreza Nikbakht Brujeni, Saeed Alamian & Mehdi Kamali. (2015) Subcutaneous immunization with a novel immunogenic candidate (urease) confers protection against Brucella abortus and Brucella melitensis infections . APMIS 123:8, pages 667-675.
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Maryam Golshani, Sima Rafati, Seyed Davar Siadat, Mehdi Nejati-Moheimani, Fereshteh Shahcheraghi, Amin Arsang & Saeid Bouzari. (2015) Improved immunogenicity and protective efficacy of a divalent DNA vaccine encoding Brucella L7/L12-truncated Omp31 fusion protein by a DNA priming and protein boosting regimen. Molecular Immunology 66:2, pages 384-391.
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Lan Yao, Chang-Xian Wu, Ke Zheng, Xian-Jin Xu, Hui Zhang, Chuang-Fu Chen & Zheng-Fei Liu. (2015) Immunogenic response to a recombinant pseudorabies virus carrying bp26 gene of Brucella melitensis in mice. Research in Veterinary Science 100, pages 61-67.
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Job Alves de Souza Filho, Vicente de Paulo Martins, Priscila Carneiro Campos, Juliana Alves-Silva, Nathalia V. Santos, Fernanda Souza de Oliveira, Gustavo B. Menezes, Vasco Azevedo, Silvio Lorenzo Cravero & Sergio Costa Oliveira. (2015) Mutant Brucella abortus Membrane Fusogenic Protein Induces Protection against Challenge Infection in Mice. Infection and Immunity 83:4, pages 1458-1464.
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Maria Clausse, Alejandra G. Díaz, Andrés E. Ibañez, Juliana Cassataro, Guillermo H. Giambartolomei & Silvia M. Estein. (2014) Evaluation of the Efficacy of Outer Membrane Protein 31 Vaccine Formulations for Protection against Brucella canis in BALB/c Mice. Clinical and Vaccine Immunology 21:12, pages 1689-1694.
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S. C. Olsen & M. V. Palmer. (2014) Advancement of Knowledge of Brucella Over the Past 50 Years . Veterinary Pathology 51:6, pages 1076-1089.
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Marie-Alice Vitry, Delphine Hanot Mambres, Carl De Trez, Shizuo Akira, Bernhard Ryffel, Jean-Jacques Letesson & Eric Muraille. (2014) Humoral Immunity and CD4+ Th1 Cells Are Both Necessary for a Fully Protective Immune Response upon Secondary Infection with Brucella melitensis . The Journal of Immunology 192:8, pages 3740-3752.
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Michael F. Criscitiello, Martin B. Dickman, James E. Samuel & Paul de Figueiredo. (2013) Tripping on Acid: Trans-Kingdom Perspectives on Biological Acids in Immunity and Pathogenesis. PLoS Pathogens 9:7, pages e1003402.
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Pengbo Ning, Mancai Guo, Kangkang Guo, Lei Xu, Min Ren, Yuanyuan Cheng & Yanming Zhang. (2013) Identification and Effect Decomposition of Risk Factors for Brucella Contamination of Raw Whole Milk in China. PLoS ONE 8:7, pages e68230.
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Eric Daniel Avila-Calderón, Ahidé Lopez-Merino, Nammalwar Sriranganathan, Stephen M. Boyle & Araceli Contreras-Rodríguez. (2013) A History of the Development of Brucella Vaccines . BioMed Research International 2013, pages 1-8.
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Marie-Alice Vitry, Carl De Trez, Stanislas Goriely, Laure Dumoutier, Shizuo Akira, Bernhard Ryffel, Yves Carlier, Jean-Jacques Letesson & Eric Muraille. (2012) Crucial Role of Gamma Interferon-Producing CD4 + Th1 Cells but Dispensable Function of CD8 + T Cell, B Cell, Th2, and Th17 Responses in the Control of Brucella melitensis Infection in Mice . Infection and Immunity 80:12, pages 4271-4280.
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Xianbo Li, Jie Xu, Yongfei Xie, Yefeng Qiu, Simei Fu, Xitong Yuan, Yuehua Ke, Shuang Yu, Xinying Du, Mingquan Cui, Yanfen Chen, Tongkun Wang, Zhoujia Wang, Yaqing Yu, Kehe Huang, Liuyu Huang, Guangneng Peng, Zeliang Chen & Yufei Wang. (2012) Vaccination with recombinant flagellar proteins FlgJ and FliN induce protection against Brucella abortus 544 infection in BALB/c mice. Veterinary Microbiology 161:1-2, pages 137-144.
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Renata Bastos, Cleber O. Soares, Carina Elisei, Anna L.R. Munhoz, Nádia L. Bezerra, Marrielen A.B. Caitano & Grácia M.S. Rosinha. (2012) Avaliação genética das vacinas contra a brucelose bovina comercializadas no Brasil. Pesquisa Veterinária Brasileira 32:10, pages 957-962.
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