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Influenza viral neuraminidase: the forgotten antigen

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Pages 1683-1695 | Published online: 09 Jan 2014

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Brian J. Ward, Stephane Pillet, Nathalie Charland, Sonia Trepanier, Julie Couillard & Nathalie Landry. (2018) The establishment of surrogates and correlates of protection: Useful tools for the licensure of effective influenza vaccines?. Human Vaccines & Immunotherapeutics 14:3, pages 647-656.
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Lisa M. Dunkle & Ruvim Izikson. (2016) Recombinant hemagglutinin influenza vaccine provides broader spectrum protection. Expert Review of Vaccines 15:8, pages 957-966.
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P Noel Barrett, Daniel Portsmouth & Hartmut J Ehrlich. (2013) Vero cell culture-derived pandemic influenza vaccines: preclinical and clinical development. Expert Review of Vaccines 12:4, pages 395-413.
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Nathalie Garçon, David W Vaughn & Arnaud M Didierlaurent. (2012) Development and evaluation of AS03, an Adjuvant System containing α-tocopherol and squalene in an oil-in-water emulsion. Expert Review of Vaccines 11:3, pages 349-366.
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Articles from other publishers (41)

Nada Abbadi & Jarrod J. Mousa. (2023) Broadly Protective Neuraminidase-Based Influenza Vaccines and Monoclonal Antibodies: Target Epitopes and Mechanisms of Action. Viruses 15:1, pages 200.
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Praveen M. Varghese, Uday Kishore & Reena Rajkumari. (2022) Innate and adaptive immune responses against Influenza A Virus: Immune evasion and vaccination strategies. Immunobiology 227:6, pages 152279.
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Vasilis C. Pliasas, Zach Menne, Virginia Aida, Ji-Hang Yin, Maria C. Naskou, Peter J. Neasham, J. Fletcher North, Dylan Wilson, Katharine A. Horzmann, Joshy Jacob, Ioanna Skountzou & Constantinos S. Kyriakis. (2022) A Novel Neuraminidase Virus-Like Particle Vaccine Offers Protection Against Heterologous H3N2 Influenza Virus Infection in the Porcine Model. Frontiers in Immunology 13.
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Miruna E. Rosu, Adinda Kok, Theo M. Bestebroer, Dennis de Meulder, Elwin P. Verveer, Mark R. Pronk, Lennard J. M. Dekker, Theo M. Luider, Mathilde Richard, Judith M. A. van den Brand, Ron A. M. Fouchier & Sander Herfst. (2022) Contribution of Neuraminidase to the Efficacy of Seasonal Split Influenza Vaccines in the Ferret Model. Journal of Virology 96:6.
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David V. McLeod, Lindi M. Wahl & Nicole Mideo. (2021) Mosaic vaccination: How distributing different vaccines across a population could improve epidemic control. Evolution Letters 5:5, pages 458-471.
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Vivian K.Y. Leung, Annette Fox, Louise A. Carolan, Malet Aban, Karen L. Laurie, Julian Druce, Yi-Mo Deng, Monica A. Slavin, Caroline Marshall & Sheena G. Sullivan. (2021) Impact of prior vaccination on antibody response and influenza-like illness among Australian healthcare workers after influenza vaccination in 2016. Vaccine 39:24, pages 3270-3278.
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Quyen-Thi Nguyen & Young-Ki Choi. (2021) Targeting Antigens for Universal Influenza Vaccine Development. Viruses 13:6, pages 973.
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Shirin Strohmeier, Juan Manuel Carreño, Ruhi Nichalle Brito & Florian Krammer. (2021) Introduction of Cysteines in the Stalk Domain of Recombinant Influenza Virus N1 Neuraminidase Enhances Protein Stability and Immunogenicity in Mice. Vaccines 9:4, pages 404.
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Kostlend Mara, Meiling Dai, Aaron M. Brice, Marina R. Alexander, Leon Tribolet, Daniel S. Layton & Andrew G. D. Bean. (2021) Investigating the Interaction between Negative Strand RNA Viruses and Their Hosts for Enhanced Vaccine Development and Production. Vaccines 9:1, pages 59.
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Isabelle Peubez, Sylvie Margot, Sophie Buffin, Corinne Pion, Marie-Clotilde Bernard, Premkumar Dinadayala, David Poncet, Sandrine Deloire, Sergio Marco & Isabelle Legastelois. (2020) A novel lamprey antibody sequence to multimerize and increase the immunogenicity of recombinant viral and bacterial vaccine antigens. Vaccine 38:50, pages 7905-7915.
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Allen Zheng, Weina Sun, Xiaoli Xiong, Alec W. Freyn, Julia Peukes, Shirin Strohmeier, Raffael Nachbagauer, John A. G. Briggs, Florian Krammer & Peter Palese. (2020) Enhancing Neuraminidase Immunogenicity of Influenza A Viruses by Rewiring RNA Packaging Signals. Journal of Virology 94:16.
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Chih-Jen Wei, Michelle C. Crank, John Shiver, Barney S. Graham, John R. Mascola & Gary J. Nabel. (2020) Next-generation influenza vaccines: opportunities and challenges. Nature Reviews Drug Discovery 19:4, pages 239-252.
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Q Sue Huang, Don Bandaranayake, Tim Wood, E Claire Newbern, Ruth Seeds, Jacqui Ralston, Ben Waite, Ange Bissielo, Namrata Prasad, Angela Todd, Lauren Jelley, Wendy Gunn, Anne McNicholas, Thomas Metz, Shirley Lawrence, Emma Collis, Amanda Retter, Sook-san Wong, Richard Webby, Judy Bocacao, Jennifer Haubrock, Graham Mackereth, Nikki Turner, Barbara McArdle, John Cameron, Edwin G Reynolds, Michael G Baker, Cameron C Grant, Colin McArthur, Sally Roberts, Adrian Trenholme, Conroy Wong, Susan Taylor, Paul Thomas, Jazmin Duque, Diane Gross, Mark G Thompson, Marc-Alain Widdowson, Kathryn Haven, Bhamita Chand, Pamela Muponisi, Debbie Aley, Claire Sherring, Miriam Rea, Judith Barry, Tracey Bushell, Julianne Brewer, Catherine McClymont, Shona Chamberlin, Reniza Ongcoy, Kirstin Davey, Emilina Jasmat, Maree Dickson, Annette Western, Olive Lai, Sheila Fowlie, Faasoa Aupa’au, Louise Robertson, Pam Kawakami, Susan Walker, Robyn Madge, Amanda des Barres, Helen Qiao, Fifi Tse, Mahtab Zibaei, Tirzah Korrapadu, Louise Optland & Cecilia Dela Cruz. (2019) Risk Factors and Attack Rates of Seasonal Influenza Infection: Results of the Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance (SHIVERS) Seroepidemiologic Cohort Study. The Journal of Infectious Diseases 219:3, pages 347-357.
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Yao-Qing Chen, Teddy John Wohlbold, Nai-Ying Zheng, Min Huang, Yunping Huang, Karlynn E. Neu, Jiwon Lee, Hongquan Wan, Karla Thatcher Rojas, Ericka Kirkpatrick, Carole Henry, Anna-Karin E. Palm, Christopher T. Stamper, Linda Yu-Ling Lan, David J. Topham, John Treanor, Jens Wrammert, Rafi Ahmed, Maryna C. Eichelberger, George Georgiou, Florian Krammer & Patrick C. Wilson. (2018) Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies. Cell 173:2, pages 417-429.e10.
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Sophie Buffin, Nabila Ikhelef, Julien Prudent, Joseline Dubayle, Nolwenn Nougarede, Marie-Pierre Varenne, Catherine Moste & Isabelle Legastelois. (2018) A latex agglutination assay to quantify the amount of hemagglutinin protein in adjuvanted low-dose influenza monovalent vaccines. Journal of Virological Methods 251, pages 46-53.
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Yu-Jin Kim, Eun-Ju Ko, Min-Chul Kim, Yu-Na Lee, Ki-Hye Kim, Yu-Jin Jung & Sang-Moo Kang. (2017) Roles of antibodies to influenza A virus hemagglutinin, neuraminidase, and M2e in conferring cross protection. Biochemical and Biophysical Research Communications 493:1, pages 393-398.
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Akira AinaiTadaki SuzukiShin-ichi TamuraHideki Hasegawa. (2017) Intranasal Administration of Whole Inactivated Influenza Virus Vaccine as a Promising Influenza Vaccine Candidate. Viral Immunology 30:6, pages 451-462.
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Lisa M. Dunkle, Ruvim Izikson, Peter Patriarca, Karen L. Goldenthal, Derek Muse, Janice Callahan & Manon M.J. Cox. (2017) Efficacy of Recombinant Influenza Vaccine in Adults 50 Years of Age or Older. New England Journal of Medicine 376:25, pages 2427-2436.
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Jin Il Kim, Ilseob Lee, Sehee Park, Joon-Yong Bae, Kirim Yoo, Hee Jin Cheong, Ji Yun Noh, Kyung Wook Hong, Philippe Lemey, Bram Vrancken, Juwon Kim, Misun Nam, Soo-Hyeon Yun, Woo In Cho, Joon Young Song, Woo Joo Kim, Mee Sook Park, Jin-Won Song, Sun-Ho Kee, Ki-Joon Song & Man-Seong Park. (2017) Phylogenetic relationships of the HA and NA genes between vaccine and seasonal influenza A(H3N2) strains in Korea. PLOS ONE 12:3, pages e0172059.
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Daniela S. Rajão, Hongjun Chen, Daniel R. Perez, Matthew R. Sandbulte, Phillip C. Gauger, Crystal L. Loving, G. Dennis Shanks & Amy Vincent. (2016) Vaccine-associated enhanced respiratory disease is influenced by haemagglutinin and neuraminidase in whole inactivated influenza virus vaccines. Journal of General Virology 97:7, pages 1489-1499.
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Shin-ichi Tamura, Akira Ainai, Tadaki Suzuki, Takeshi Kurata & Hideki Hasegawa. (2016) Intranasal Inactivated Influenza Vaccines: a Reasonable Approach to Improve the Efficacy of Influenza Vaccine?. Japanese Journal of Infectious Diseases 69:3, pages 165-179.
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Freek Cox, Matthijs Baart, Jeroen Huizingh, Jeroen Tolboom, Liesbeth Dekking, Jaap Goudsmit, Eirikur Saeland & Katarina Radošević. (2015) Protection against H5N1 Influenza Virus Induced by Matrix-M Adjuvanted Seasonal Virosomal Vaccine in Mice Requires Both Antibodies and T Cells. PLOS ONE 10:12, pages e0145243.
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Joshua G. Petrie, Suzanne E. Ohmit, Emileigh Johnson, Rachel Truscon & Arnold S. Monto. (2015) Persistence of Antibodies to Influenza Hemagglutinin and Neuraminidase Following One or Two Years of Influenza Vaccination. Journal of Infectious Diseases 212:12, pages 1914-1922.
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Arnold S. Monto, Joshua G. Petrie, Rachel T. Cross, Emileigh Johnson, Merry Liu, Weimin Zhong, Min Levine, Jacqueline M. Katz & Suzanne E. Ohmit. (2015) Antibody to Influenza Virus Neuraminidase: An Independent Correlate of Protection. Journal of Infectious Diseases 212:8, pages 1191-1199.
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Freek Cox, Anna Roos, Nicole Hafkemeijer, Matthijs Baart, Jeroen Tolboom, Liesbeth Dekking, Koert Stittelaar, Jaap Goudsmit, Katarina Radošević & Eirikur Saeland. (2015) Matrix-M Adjuvated Seasonal Virosomal Influenza Vaccine Induces Partial Protection in Mice and Ferrets against Avian H5 and H7 Challenge. PLOS ONE 10:9, pages e0135723.
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Marua Prevato, Ilaria Ferlenghi, Alessandra Bonci, Yasushi Uematsu, Giulia Anselmi, Fabiola Giusti, Sylvie Bertholet, Francois Legay, John Laird Telford, Ethan C. Settembre, Domenico Maione & Roberta Cozzi. (2015) Expression and Characterization of Recombinant, Tetrameric and Enzymatically Active Influenza Neuraminidase for the Setup of an Enzyme-Linked Lectin-Based Assay. PLOS ONE 10:8, pages e0135474.
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Marua Prevato, Roberta Cozzi, Alfredo Pezzicoli, Anna Rita Taddei, Ilaria Ferlenghi, Avishek Nandi, Emanuele Montomoli, Ethan C. Settembre, Sylvie Bertholet, Alessandra Bonci & Francois Legay. (2015) An Innovative Pseudotypes-Based Enzyme-Linked Lectin Assay for the Measurement of Functional Anti-Neuraminidase Antibodies. PLOS ONE 10:8, pages e0135383.
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Hong Zhang, Qinglin Han, Xianqiang Ping, Li Li, Chong Chang, Ze Chen, Yuelong Shu, Ke Xu & Bing Sun. (2015) A single NS2 mutation of K86R promotes PR8 vaccine donor virus growth in Vero cells. Virology 482, pages 32-40.
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Wen-Chun Liu, Chia-Ying Lin, Yung-Ta Tsou, Jia-Tsrong Jan & Suh-Chin Wu. (2015) Cross-Reactive Neuraminidase-Inhibiting Antibodies Elicited by Immunization with Recombinant Neuraminidase Proteins of H5N1 and Pandemic H1N1 Influenza A Viruses. Journal of Virology 89:14, pages 7224-7234.
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Lidewij Wiersma, Guus Rimmelzwaan & Rory de Vries. (2015) Developing Universal Influenza Vaccines: Hitting the Nail, Not Just on the Head. Vaccines 3:2, pages 239-262.
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Stefan J. Halbherr, Thomas H. Ludersdorfer, Meret Ricklin, Samira Locher, Marianne Berger Rentsch, Artur Summerfield & Gert Zimmer. (2015) Biological and Protective Properties of Immune Sera Directed to the Influenza Virus Neuraminidase. Journal of Virology 89:3, pages 1550-1563.
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Han Lei, Xiaojue Peng, Daxian Zhao, Jiexiu Ouyang, Huifeng Jiao, Handing Shu & Xinqi Ge. (2015) Lactococcus lactis displayed neuraminidase confers cross protective immunity against influenza A viruses in mice. Virology 476, pages 189-195.
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Weibin Hu, Hong Zhang, Qinglin Han, Li Li, Yixin Chen, Ningshao Xia, Ze Chen, Yuelong Shu, Ke Xu & Bing Sun. (2015) A Vero-cell-adapted vaccine donor strain of influenza A virus generated by serial passages. Vaccine 33:2, pages 374-381.
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Ahmad M. Haredy, Hiroshi Yamada, Yoshihiro Sakoda, Masatoshi Okamatsu, Naoki Yamamoto, Takeshi Omasa, Yasuko Mori, Hiroshi Kida, Shigefumi Okamoto, Yoshinobu Okuno & Koichi Yamanishi. (2014) Neuraminidase gene homology contributes to the protective activity of influenza vaccines prepared from the influenza virus library. Journal of General Virology 95:11, pages 2365-2371.
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Teddy Wohlbold & Florian Krammer. (2014) In the Shadow of Hemagglutinin: A Growing Interest in Influenza Viral Neuraminidase and Its Role as a Vaccine Antigen. Viruses 6:6, pages 2465-2494.
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