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Review

Botulinum toxin type A products are not interchangeable: a review of the evidence

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Pages 227-241 | Published online: 06 Oct 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

David C Rupp, David Canty, Catherine Rhéaume, Birgitte Sondergaard, Celina Niño, Ron S Broide & Amy D Brideau-Andersen. (2023) A Preclinical Study Comparing the Activity and Potency of OnabotulinumtoxinA and PrabotulinumtoxinA. Clinical, Cosmetic and Investigational Dermatology 16, pages 581-591.
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Jürgen Frevert, Ki Young Ahn, Mee Young Park & Owen Sunga. (2018) Comparison of botulinum neurotoxin type A formulations in Asia. Clinical, Cosmetic and Investigational Dermatology 11, pages 327-331.
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Michael Kennelly, Lonny Green, Nancy Alvandi, Salim Wehbe, John Joseph Smith$suffix/text()$suffix/text(), Scott MacDiarmid, Jeffrey Mangel, Marc Schwartz, Tamer Aboushwareb & Brian Murray. (2018) Clean intermittent catheterization rates after initial and subsequent treatments with onabotulinumtoxinA for non-neurogenic overactive bladder in real-world clinical settings. Current Medical Research and Opinion 34:10, pages 1771-1776.
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Christine Hosp & Henning Hamm. (2017) Safety of available and emerging drug therapies for hyperhidrosis. Expert Opinion on Drug Safety 16:9, pages 1039-1049.
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Articles from other publishers (29)

Ileana M. Howard & Atul T. Patel. (2023) Spasticity evaluation and management tools. Muscle & Nerve 67:4, pages 272-283.
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Parisa Gazerani. (2022) How Does Botulinum Toxin Inhibit Itch?. Toxins 14:10, pages 701.
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Paula A. Benítez. (2021) Onabotulinumtoxin A for correcting trapezius muscle hypertrophy in Asian women. Journal of Cosmetic Dermatology 21:6, pages 2677-2679.
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Wu‐chao Liu, Jun‐hui Su, Ya Feng, Xue‐rui Xiang, Li‐zhen Pan, Ying Liu, Lin Ma, Zhi‐yu Nie, Xue‐ping Zhang & Ling‐jing Jin. (2022) Dynamic muscle paralytic effects of a novel botulinum toxin A free of neurotoxin‐associated proteins. Pharmacology Research & Perspectives 10:3.
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Pengxu Wei. (2022) Botulinum Toxin Injection for the Treatment of Upper Esophageal Sphincter Dysfunction. Toxins 14:5, pages 321.
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Alexander D. Nassif, Ricardo F. Boggio, Sheila Espicalsky & Gladstone E. L. Faria. (2022) High Precision Use of Botulinum Toxin Type A (BONT-A) in Aesthetics Based on Muscle Atrophy, Is Muscular Architecture Reprogramming a Possibility? A Systematic Review of Literature on Muscle Atrophy after BoNT-A Injections. Toxins 14:2, pages 81.
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Thays Crosara Abrahão Cunha, Ana Claudia Gontijo Couto, Eduardo Januzzi, Rafael Tardin Rosa Ferraz Gonçalves, Graziella Silva & Cassia Regina Silva. (2021) Analgesic potential of different available commercial brands of botulinum neurotoxin-A in formalin-induced orofacial pain in mice. Toxicon: X 12, pages 100083.
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Kateřina Menšíková, Martin Nevrlý, Lenka Hvizdošová, Michaela Kaiserová, Sandra Kurčová, Miroslav Vaštík, Jan Bardoň, Tereza Bartoníková, Zuzana Grambalová, Aleš Grambal, Pavel Otruba & Petr Kaňovský. (2021) The current state of pharmacotherapy for extrapyramidal diseases. Neurologie pro praxi 22:3, pages 183-193.
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Joely Kaufman-Janette, Sue Ellen Cox, Steven Dayan & John Joseph. (2021) Botulinum Toxin Type A for Glabellar Frown Lines: What Impact of Higher Doses on Outcomes?. Toxins 13:7, pages 494.
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Ruth Kent, Adrian Robertson, Sandra Quiñones Aguilar, Charalampos Tzoulis & John Maltman. (2021) Real-World Dosing of OnabotulinumtoxinA and IncobotulinumtoxinA for Cervical Dystonia and Blepharospasm: Results from TRUDOSE and TRUDOSE II. Toxins 13:7, pages 488.
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Supriyo Choudhury, Mark R. Baker, Suparna Chatterjee & Hrishikesh Kumar. (2021) Botulinum Toxin: An Update on Pharmacology and Newer Products in Development. Toxins 13:1, pages 58.
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V.Yu. Avtomonov & E.A. Razumovskaya. (2021) Botulinum toxins in cosmetology: clarifications. Klinicheskaya dermatologiya i venerologiya 20:4, pages 135.
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P. Chaichanavichkij, P. F. Vollebregt, S. M. Scott & C. H. Knowles. (2020) Botulinum toxin type A for the treatment of dyssynergic defaecation in adults: a systematic review. Colorectal Disease 22:12, pages 1832-1841.
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Mark S. Nestor, David Arnold & Daniel Fischer. (2020) The mechanisms of action and use of botulinum neurotoxin type A in aesthetics: Key Clinical Postulates II. Journal of Cosmetic Dermatology 19:11, pages 2785-2804.
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Alberto Esquenazi, Mauricio R. Delgado, Robert A. Hauser, Philippe Picaut, Keith Foster, Andreas Lysandropoulos & Jean-Michel Gracies. (2020) Duration of Symptom Relief Between Injections for AbobotulinumtoxinA (Dysport®) in Spastic Paresis and Cervical Dystonia: Comparison of Evidence From Clinical Studies. Frontiers in Neurology 11.
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David Rupp, Greg Nicholson, David Canty, Joanne Wang, Catherine Rhéaume, Linh Le, Lance E. Steward, Mark Washburn, Birgitte P. Jacky, Ron S. Broide, Wolfgang G. Philipp-Dormston, Mitchell F. Brin & Amy Brideau-Andersen. (2020) OnabotulinumtoxinA Displays Greater Biological Activity Compared to IncobotulinumtoxinA, Demonstrating Non-Interchangeability in Both In Vitro and In Vivo Assays. Toxins 12:6, pages 393.
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Lenka Hvizdošová, Pavel Otruba, Martin Nevrlý & Petr Kaňovský. (2020) Botulinum toxin A in the treatment of dystonia. Neurologie pro praxi 21:1, pages 21-26.
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Masahiro Abo, Takashi Shigematsu, Hiroyoshi Hara, Yasuko Matsuda, Akinori Nimura, Yoshiyuki Yamashita & Kaoru Takahashi. (2020) Efficacy and Safety of OnabotulinumtoxinA 400 Units in Patients with Post-Stroke Upper Limb Spasticity: Final Report of a Randomized, Double-Blind, Placebo-Controlled Trial with an Open-Label Extension Phase. Toxins 12:2, pages 127.
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C. Koh, C.V. Melling, C. Jennings, M. Lewis & A. Goyal. (2019) Efficacy of electromotive drug administration in delivering botulinum toxin a in children with neuropathic detrusor overactivity—outcomes of a pilot study. Journal of Pediatric Urology 15:5, pages 552.e1-552.e8.
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Hee Young Son. (2019) Practical Issue of Botulinum Toxin use Liquid Type, Storage and Reuse. Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics 30:1, pages 9-11.
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Julián Balanta-Melo, Viviana Toro-Ibacache, Kornelius Kupczik & Sonja Buvinic. (2019) Mandibular Bone Loss after Masticatory Muscles Intervention with Botulinum Toxin: An Approach from Basic Research to Clinical Findings. Toxins 11:2, pages 84.
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Elena Fonfria. 2018. Neurotoxins. Neurotoxins.
Elena Fonfria, Jacquie Maignel, Stephane Lezmi, Vincent Martin, Andrew Splevins, Saif Shubber, Mikhail Kalinichev, Keith Foster, Philippe Picaut & Johannes Krupp. (2018) The Expanding Therapeutic Utility of Botulinum Neurotoxins. Toxins 10:5, pages 208.
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JTE Lim, DK Loh, K Soh & O Sunga. (2017) Efficacy and patient satisfaction with incobotulinumtoxinA for the treatment of glabellar frown lines. Singapore Medical Journal 58:10, pages 606-609.
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Emmanuel Chartier‐Kastler, Eric Rovner, Zsolt Hepp, Kristin Khalaf, Quanhong Ni & Michael Chancellor. (2015) Patient‐reported goal achievement following onabotulinumtoxinA treatment in patients with neurogenic detrusor overactivity. Neurourology and Urodynamics 35:5, pages 595-600.
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Anna Rita Bentivoglio, Alessandra Del Grande, Martina Petracca, Tamara Ialongo & Lucia Ricciardi. (2015) Clinical differences between botulinum neurotoxin type A and B. Toxicon 107, pages 77-84.
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Stéphanie Simon, Uwe Fiebig, Yvonne Liu, Rob Tierney, Julie Dano, Sylvia Worbs, Tanja Endermann, Marie-Claire Nevers, Hervé Volland, Dorothea Sesardic & Martin Dorner. (2015) Recommended Immunological Strategies to Screen for Botulinum Neurotoxin-Containing Samples. Toxins 7:12, pages 5011-5034.
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Yu-Ching Lin. (2015) Predicting the Response to Botulinum Toxin Treatment in Children With Cerebral Palsy. Archives of Physical Medicine and Rehabilitation 96:4, pages 760.
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Wolfgang H. Jost. (2015) ‘Similar To’ Is Not ‘Identical With’, and ‘Identical With’ Is Not ‘The Same As’. Drugs in R&D 15:1, pages 11-12.
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