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Review

Pertuzumab in the treatment of HER2-positive breast cancer: an evidence-based review of its safety, efficacy, and place in therapy

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Pages 51-70 | Published online: 31 Oct 2019

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Jin Wang, Dongying Liao, Xuemin Zhang, Changhong Miao & Kuang Chen. (2023) Can Patients with HER2-Low Breast Cancer Benefit from Anti-HER2 Therapies? A Review. Breast Cancer: Targets and Therapy 15, pages 281-294.
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Shuai Jiang, Shuai Geng, Xinyue Gao, Tong Liu, Xinyu Luo, Nan Wang, Ning Shi & Mei Dong. (2023) Evaluation of HER-2 positive breast cancer treated with dual-targeted treatment of trastuzumab plus pertuzumab. Immunopharmacology and Immunotoxicology 45:5, pages 616-625.
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Yongchao Yu, Jin Wang, Dongying Liao, Dou Zhang, Xiaojiang Li, Yingjie Jia & Fanming Kong. (2022) Advances in Antibody-Drug Conjugates in the Treatment of HER2-Positive Breast Cancer. Breast Cancer: Targets and Therapy 14, pages 417-432.
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Guangwen Liu, Zhongnan Xu, Wei Yang, Jinling Xue, Yanli Wang, Zhengzhi Liu, Yingzi Cui, Xinyao Qu, Tianying Chang, Shuang Yu, Yang Cheng, Yannan Zhou, Jiahui Chen, Qing Ren, Wanhua Wang, Qiaohuan Deng, Zeyu Wang & Haimiao Yang. (2022) A randomized, double-blind, single-dose, single-center, parallel phase I clinical study comparing the pharmacokinetics, immunogenicity, safety, and tolerance of pertuzumab injection and Perjeta® in healthy Chinese male subjects. Expert Opinion on Biological Therapy 22:2, pages 187-195.
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Andrea Luque-Bolivar, Erika Pérez-Mora, Victoria Eugenia Villegas & Milena Rondón-Lagos. (2020) Resistance and Overcoming Resistance in Breast Cancer. Breast Cancer: Targets and Therapy 12, pages 211-229.
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Articles from other publishers (35)

Puneet K Singh & Razvan C Stan. (2023) Enhanced binding at fever temperatures of HER2 in complex with trastuzumab and pertuzumab. Immunotherapy 15:13, pages 1021-1027.
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Faizan Fazal, Muhammad Nauman Bashir, Maham Leeza Adil, Usama Tanveer, Mansoor Ahmed, Taha Zahid Chaudhry, Ali Ahmad Ijaz & Muhammad Haider. (2023) Pathologic Complete Response Achieved in Early-Stage HER2-Positive Breast Cancer After Neoadjuvant Therapy With Trastuzumab and Chemotherapy vs. Trastuzumab, Chemotherapy, and Pertuzumab: A Systematic Review and Meta-Analysis of Clinical Trials. Cureus.
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Shima Yousefi Rizi, Sun-Hee Kim, Jung-Hoon Lee & Hee-Jin Jeong. (2023) Generation of an scFv-type Quenchbody Against HER2 for Sensitive Detection of Human Breast Cancer. KSBB Journal 38:1, pages 35-45.
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Oladapo Olaleye, Baubek Spanov, Peter Bults, Anna van der Voort, Natalia Govorukhina, Gabe S. Sonke, Peter Horvatovich, Nico C. van de Merbel & Rainer Bischoff. (2023) Biotransformation of Trastuzumab and Pertuzumab in Breast Cancer Patients Assessed by Affinity Enrichment and Ion-Exchange Chromatography. Drug Metabolism and Disposition 51:2, pages 249-256.
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Sandra M. Swain, Mythili Shastry & Erika Hamilton. (2022) Targeting HER2-positive breast cancer: advances and future directions. Nature Reviews Drug Discovery 22:2, pages 101-126.
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Desh Deepak Singh, Hae-Jeung Lee & Dharmendra Kumar Yadav. (2022) Clinical updates on tyrosine kinase inhibitors in HER2-positive breast cancer. Frontiers in Pharmacology 13.
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Joshua Tobias, Mirjana Drinić, Anna Schmid, Anastasiya Hladik, Martin L. Watzenböck, Claire Battin, Erika Garner-Spitzer, Peter Steinberger, Michael Kundi, Sylvia Knapp, Christoph C. Zielinski & Ursula Wiedermann. (2022) Combined Vaccination with B Cell Peptides Targeting Her-2/neu and Immune Checkpoints as Emerging Treatment Option in Cancer. Cancers 14:22, pages 5678.
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Jiangang Sun, Xiaojing Li, Peng Chen & Yongshun Gao. (2022) From Anti-HER-2 to Anti-HER-2-CAR-T Cells: An Evolutionary Immunotherapy Approach for Gastric Cancer. Journal of Inflammation Research Volume 15, pages 4061-4085.
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Santiago Moragon, Cristina Hernando, Maria Teresa Martinez-Martinez, Marta Tapia, Belen Ortega-Morillo, Ana Lluch, Begoña Bermejo & Juan Miguel Cejalvo. (2022) Immunological Landscape of HER-2 Positive Breast Cancer. Cancers 14:13, pages 3167.
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Sreeja Raj MenonArpit MitraAvik ChakrabortyMegha TawateSudeep SahuSutapa RakshitSujay GaikwadGeetanjali DhotreArchana DamleSharmila Banerjee. (2022) Clinical Dose Preparation of [ 177 Lu]Lu-DOTA-Pertuzumab Using Medium Specific Activity [ 177 Lu]LuCl 3 for Radioimmunotherapy of Breast and Epithelial Ovarian Cancers, with HER2 Receptor Overexpression . Cancer Biotherapy and Radiopharmaceuticals 37:5, pages 384-402.
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