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Review

An evidence-based review of obatoclax mesylate in the treatment of hematological malignancies

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Pages 15-26 | Published online: 14 Mar 2013

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German A. Islan, Boris Rodenak-Kladniew, Nehuen Noacco, Nelson Duran & Guillermo R. Castro. (2022) Prodigiosin: a promising biomolecule with many potential biomedical applications. Bioengineered 13:6, pages 14227-14258.
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Jennifer R. Brown, Bethany Tesar, Lijian Yu, Lillian Werner, Naoko Takebe, Evgeny Mikler, Hazel M. Reynolds, Christina Thompson, David C. Fisher, Donna Neuberg & A. S. Freedman. (2015) Obatoclax in combination with fludarabine and rituximab is well-tolerated and shows promising clinical activity in relapsed chronic lymphocytic leukemia. Leukemia & Lymphoma 56:12, pages 3336-3342.
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Jane Huang, Wayne Fairbrother & John C Reed. (2015) Therapeutic targeting of Bcl-2 family for treatment of B-cell malignancies. Expert Review of Hematology 8:3, pages 283-297.
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Shadia Zaman, Rui Wang & Varsha Gandhi. (2014) Targeting the apoptosis pathway in hematologic malignancies. Leukemia & Lymphoma 55:9, pages 1980-1992.
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Margarita Espona-Fiedler, Pilar Manuel-Manresa, Cristina Benítez-García, Pere Fontova, Roberto Quesada, Vanessa Soto-Cerrato & Ricardo Pérez-Tomás. (2022) Antimetastatic Properties of Prodigiosin and the BH3-Mimetic Obatoclax (GX15-070) in Melanoma. Pharmaceutics 15:1, pages 97.
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Monica D. Reece, Colin Song, Sarah C. Hancock, Susan Pereira Ribeiro, Deanna A. Kulpa & Christina Gavegnano. (2022) Repurposing BCL-2 and Jak 1/2 inhibitors: Cure and treatment of HIV-1 and other viral infections. Frontiers in Immunology 13.
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Adrià Molero-Valenzuela, Pere Fontova, Daniel Alonso-Carrillo, Israel Carreira-Barral, Ana Aurora Torres, María García-Valverde, Cristina Benítez-García, Ricardo Pérez-Tomás, Roberto Quesada & Vanessa Soto-Cerrato. (2022) A Novel Late-Stage Autophagy Inhibitor That Efficiently Targets Lysosomes Inducing Potent Cytotoxic and Sensitizing Effects in Lung Cancer. Cancers 14:14, pages 3387.
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Jingye Li, Jinrong Xu & Zhibing Li. (2021) Obatoclax, the pan-Bcl-2 inhibitor sensitizes hepatocellular carcinoma cells to promote the anti-tumor efficacy in combination with immune checkpoint blockade. Translational Oncology 14:8, pages 101116.
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Małgorzata Opydo-Chanek, Iwona Cichoń, Agnieszka Rak, Elżbieta Kołaczkowska & Lidia Mazur. (2020) The pan-Bcl-2 inhibitor obatoclax promotes differentiation and apoptosis of acute myeloid leukemia cells. Investigational New Drugs 38:6, pages 1664-1676.
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Chi-Hung R. Or, Chiao-Wen Huang, Ching-Chin Chang, You-Chen Lai, Yi-Ju Chen & Chia-Che Chang. (2020) Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling. International Journal of Molecular Sciences 21:5, pages 1773.
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Shu Yang, Yujia Mao, Huijun Zhang, Yan Xu, Jing An & Ziwei Huang. (2019) The chemical biology of apoptosis: Revisited after 17 years. European Journal of Medicinal Chemistry 177, pages 63-75.
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Thomas Steele, George Talbott, Anhao Sam, Clifford Tepper, Paramita Ghosh & Ruth Vinall. (2019) Obatoclax, a BH3 Mimetic, Enhances Cisplatin-Induced Apoptosis and Decreases the Clonogenicity of Muscle Invasive Bladder Cancer Cells via Mechanisms That Involve the Inhibition of Pro-Survival Molecules as Well as Cell Cycle Regulators. International Journal of Molecular Sciences 20:6, pages 1285.
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Shane Cheung, Dan Wu, Harrison C. Daly, Nathalie Busschaert, Marina Morgunova, Jeremy C. Simpson, Dimitri Scholz, Philip A. Gale & Donal F. O'Shea. (2018) Real-Time Recording of the Cellular Effects of the Anion Transporter Prodigiosin. Chem 4:4, pages 879-895.
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Alma Abou Samra, Aude Robert, Crystal Gov, Loëtitia Favre, Laure Eloy, Eric Jacquet, Jérôme Bignon, Joëlle Wiels, Sandy Desrat & Fanny Roussi. (2018) Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A. European Journal of Medicinal Chemistry 148, pages 26-38.
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Stepana Boukalova, Katerina Rohlenova, Jakub Rohlena & Jiri Neuzil. 2018. Mitochondrial Biology and Experimental Therapeutics. Mitochondrial Biology and Experimental Therapeutics 613 635 .
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Małgorzata Opydo-Chanek, Oscar Gonzalo & Isabel Marzo. (2017) Multifaceted anticancer activity of BH3 mimetics: Current evidence and future prospects. Biochemical Pharmacology 136, pages 12-23.
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Finny S. Varghese, Kai Rausalu, Marika Hakanen, Sirle Saul, Beate M. Kümmerer, Petri Susi, Andres Merits & Tero Ahola. (2017) Obatoclax Inhibits Alphavirus Membrane Fusion by Neutralizing the Acidic Environment of Endocytic Compartments. Antimicrobial Agents and Chemotherapy 61:3.
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Kate-lyn A. R. Lund, Carlotta Figliola, Aleksandra K. Kajetanowicz & Alison Thompson. (2017) Synthesis and anticancer activity of prodigiosenes bearing C-ring esters and amides. RSC Advances 7:30, pages 18617-18627.
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Chi-Hung Or, Yachu Chang, Wei-Cheng Lin, Wee-Chyan Lee, Hong-Lin Su, Muk-Wing Cheung, Chang-Po Huang, Cheesang Ho & Chia-Che Chang. (2016) Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells. International Journal of Molecular Sciences 18:1, pages 44.
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Michaela Waibel, Gareth Gregory, Jake Shortt & Ricky W. Johnstone. (2014) Rational combination therapies targeting survival signaling in aggressive B-cell leukemia/lymphoma. Current Opinion in Hematology 21:4, pages 297-308.
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X Niu, G Wang, Y Wang, J T Caldwell, H Edwards, C Xie, J W Taub, C Li, H Lin & Y Ge. (2014) Acute myeloid leukemia cells harboring MLL fusion genes or with the acute promyelocytic leukemia phenotype are sensitive to the Bcl-2-selective inhibitor ABT-199. Leukemia 28:7, pages 1557-1560.
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K Brinkmann & H Kashkar. (2014) Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies?. Cell Death & Disease 5:3, pages e1098-e1098.
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David Wroblewski, Chen Chen Jiang, Amanda Croft, Margaret L. Farrelly, Xu Dong Zhang & Peter Hersey. (2013) OBATOCLAX and ABT-737 Induce ER Stress Responses in Human Melanoma Cells that Limit Induction of Apoptosis. PLoS ONE 8:12, pages e84073.
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