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Review

Why targeting the microbiome is not so successful: can randomness overcome the adaptation that occurs following gut manipulation?

Pages 209-217 | Published online: 08 May 2019

Keep up to date with the latest research on this topic with citation updates for this article.

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Yotam Kolben, Henny Azmanov, Ram Gelman, Danna Dror & Yaron Ilan. (2023) Using chronobiology-based second-generation artificial intelligence digital system for overcoming antimicrobial drug resistance in chronic infections. Annals of Medicine 55:1, pages 311-318.
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Articles from other publishers (41)

Yaron Ilan. (2023) Constrained disorder principle-based variability is fundamental for biological processes: Beyond biological relativity and physiological regulatory networks. Progress in Biophysics and Molecular Biology 180-181, pages 37-48.
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Ram Gelman, Noa Hurvitz, Rima Nesserat, Yotam Kolben, Dean Nachman, Khurram Jamil, Samuel Agus, Rabea Asleh, Offer Amir, Marc Berg & Yaron Ilan. (2023) A second-generation artificial intelligence-based therapeutic regimen improves diuretic resistance in heart failure: Results of a feasibility open-labeled clinical trial. Biomedicine & Pharmacotherapy 161, pages 114334.
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Yaron Ilan. (2023) Making use of noise in biological systems. Progress in Biophysics and Molecular Biology 178, pages 83-90.
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Yaron Ilan. (2022) Microtubules as a potential platform for energy transfer in biological systems: a target for implementing individualized, dynamic variability patterns to improve organ function. Molecular and Cellular Biochemistry 478:2, pages 375-392.
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Noa Hurvitz, Narmine Elkhateeb, Tal Sigawi, Lilah Rinsky-Halivni & Yaron Ilan. (2022) Improving the effectiveness of anti-aging modalities by using the constrained disorder principle-based management algorithms. Frontiers in Aging 3.
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Yaron Ilan. (2022) Enhancing the plasticity, proper function and efficient use of energy of the Sun, genes and microtubules using variability. Clinical and Translational Discovery 2:4.
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Anat Hershko-Moshe, Yaako’v Hasin, Anat Nevo-Shor, Ohad Etzion & Yaron Ilan. (2022) Improving the Treatment Response of Patients with Irritable Bowel Syndrome: Implementing a Second-Generation Artificial Intelligence System for Overcoming Resistance. GastroHep 2022, pages 1-12.
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Ying Hu, Bangjie Chen, Fan Yang, Yue Su, Dashuai Yang, Yan Yao, Shuxian Wang, Yincui Wu, Liangsong Tao & Tao Xu. (2022) Emerging role of the cGAS-STING signaling pathway in autoimmune diseases: Biologic function, mechanisms and clinical prospection. Autoimmunity Reviews 21:9, pages 103155.
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Yaron Ilan. (2022) Next-Generation Personalized Medicine: Implementation of Variability Patterns for Overcoming Drug Resistance in Chronic Diseases. Journal of Personalized Medicine 12:8, pages 1303.
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Eliana Mariño. (2022) SCFAs in T1D: A microbiota-targeted approach for immune tolerance. Current Opinion in Endocrine and Metabolic Research 24, pages 100355.
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Yinglin Xia & Jun Sun. 2022. Statistical Data Analysis of Microbiomes and Metabolomics. Statistical Data Analysis of Microbiomes and Metabolomics.
Ram Gelman, Marc Berg & Yaron Ilan. (2022) A Subject-Tailored Variability-Based Platform for Overcoming the Plateau Effect in Sports Training: A Narrative Review. International Journal of Environmental Research and Public Health 19:3, pages 1722.
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Yaron Ilan. (2022) Digital Medical Cannabis as Market Differentiator: Second-Generation Artificial Intelligence Systems to Improve Response. Frontiers in Medicine 8.
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Assaf Potruch, Asaf Schwartz & Yaron Ilan. (2022) The role of bacterial translocation in sepsis: a new target for therapy. Therapeutic Advances in Gastroenterology 15, pages 175628482210942.
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Dory Rotnemer-Golinkin & Yaron Ilan. (2022) Personalized-Inherent Variability in a Time-Dependent Immune Response: A Look into the Fifth Dimension in Biology. Pharmacology 107:7-8, pages 417-422.
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Yaron Ilan. (2022) The constrained disorder principle defines living organisms and provides a method for correcting disturbed biological systems. Computational and Structural Biotechnology Journal 20, pages 6087-6096.
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John D. Sterrett, Nathan D. Andersen & Christopher A. Lowry. 2022. Evolution, Biodiversity and a Reassessment of the Hygiene Hypothesis. Evolution, Biodiversity and a Reassessment of the Hygiene Hypothesis 267 337 .
Yuval Ishay, Assaf Potruch, Asaf Schwartz, Marc Berg, Khurram Jamil, Samuel Agus & Yaron Ilan. (2021) A digital health platform for assisting the diagnosis and monitoring of COVID-19 progression: An adjuvant approach for augmenting the antiviral response and mitigating the immune-mediated target organ damage. Biomedicine & Pharmacotherapy 143, pages 112228.
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Yuval Ishay, Yotam Kolben, Asa Kessler & Yaron Ilan. (2021) Role of circadian rhythm and autonomic nervous system in liver function: a hypothetical basis for improving the management of hepatic encephalopathy. American Journal of Physiology-Gastrointestinal and Liver Physiology 321:4, pages G400-G412.
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Noa Hurvitz, Henny Azmanov, Asa Kesler & Yaron Ilan. (2021) Establishing a second-generation artificial intelligence-based system for improving diagnosis, treatment, and monitoring of patients with rare diseases. European Journal of Human Genetics 29:10, pages 1485-1490.
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Ariel Kenig, Yotam Kolben, Rabea Asleh, Offer Amir & Yaron Ilan. (2021) Improving Diuretic Response in Heart Failure by Implementing a Patient-Tailored Variability and Chronotherapy-Guided Algorithm. Frontiers in Cardiovascular Medicine 8.
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Yehudit Shabat, Yoav Lichtenstein & Yaron Ilan. (2020) Short-Term Cohousing of Sick with Healthy or Treated Mice Alleviates the Inflammatory Response and Liver Damage. Inflammation 44:2, pages 518-525.
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Tawfik Khoury & Yaron Ilan. (2021) Platform introducing individually tailored variability in nerve stimulations and dietary regimen to prevent weight regain following weight loss in patients with obesity. Obesity Research & Clinical Practice 15:2, pages 114-123.
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Yotam Kolben, Sarah Weksler‐Zangen & Yaron Ilan. (2020) Adropin as a potential mediator of the metabolic system‐autonomic nervous system‐chronobiology axis: Implementing a personalized signature‐based platform for chronotherapy. Obesity Reviews 22:2.
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Yaron Ilan. (2021) Improving Global Healthcare and Reducing Costs Using Second-Generation Artificial Intelligence-Based Digital Pills: A Market Disruptor. International Journal of Environmental Research and Public Health 18:2, pages 811.
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Yaron Ilan. (2020) Second-Generation Digital Health Platforms: Placing the Patient at the Center and Focusing on Clinical Outcomes. Frontiers in Digital Health 2.
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Doris Vandeputte. (2020) Personalized Nutrition Through The Gut Microbiota: Current Insights And Future Perspectives. Nutrition Reviews 78:Supplement_3, pages 66-74.
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Asa Kessler, Sarah Weksler-Zangen & Yaron Ilan. (2020) Role of the Immune System and the Circadian Rhythm in the Pathogenesis of Chronic Pancreatitis. Pancreas 49:8, pages 1024-1032.
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Yaron Ilan. (2020) Overcoming Compensatory Mechanisms toward Chronic Drug Administration to Ensure Long-Term, Sustainable Beneficial Effects. Molecular Therapy - Methods & Clinical Development 18, pages 335-344.
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Assaf Potruch, Salim T. Khoury & Yaron Ilan. (2020) The role of chronobiology in drug-resistance epilepsy: The potential use of a variability and chronotherapy-based individualized platform for improving the response to anti-seizure drugs. Seizure 80, pages 201-211.
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Esther Forkosh, Ariel Kenig & Yaron Ilan. (2020) Introducing variability in targeting the microtubules: Review of current mechanisms and future directions in colchicine therapy. Pharmacology Research & Perspectives 8:4.
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Stephanie A. Flowers, Shubha Bhat & James C. Lee. (2020) Potential Implications of Gut Microbiota in Drug Pharmacokinetics and Bioavailability. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 40:7, pages 704-712.
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Yuval Ishay, Dean Nachman, Tawfik Khoury & Yaron Ilan. (2020) The role of the sphingolipid pathway in liver fibrosis: an emerging new potential target for novel therapies. American Journal of Physiology-Cell Physiology 318:6, pages C1055-C1064.
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Yaron Ilan. (2020) Order Through Disorder: The Characteristic Variability of Systems. Frontiers in Cell and Developmental Biology 8.
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Yaron Ilan. (2020) Advanced Tailored Randomness: A Novel Approach for Improving the Efficacy of Biological Systems. Journal of Computational Biology 27:1, pages 20-29.
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Yaron Ilan & Zachary Spigelman. (2020) Establishing patient-tailored variability-based paradigms for anti-cancer therapy: Using the inherent trajectories which underlie cancer for overcoming drug resistance. Cancer Treatment and Research Communications 25, pages 100240.
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Yinglin Xia. 2020. The Microbiome in Health and Disease. The Microbiome in Health and Disease 309 491 .
Ariel Kenig & Yaron Ilan. (2019) A Personalized Signature and Chronotherapy-Based Platform for Improving the Efficacy of Sepsis Treatment. Frontiers in Physiology 10.
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Yaron Ilan. (2019) Overcoming randomness does not rule out the importance of inherent randomness for functionality. Journal of Biosciences 44:6.
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Tawfik Khoury & Yaron Ilan. (2019) Introducing Patterns of Variability for Overcoming Compensatory Adaptation of the Immune System to Immunomodulatory Agents: A Novel Method for Improving Clinical Response to Anti-TNF Therapies. Frontiers in Immunology 10.
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Madi El-Haj, Dimitri Kanovitch & Yaron Ilan. (2019) Personalized inherent randomness of the immune system is manifested by an individualized response to immune triggers and immunomodulatory therapies: a novel platform for designing personalized immunotherapies. Immunologic Research 67:4-5, pages 337-347.
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