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Clinical Interventions in Aging Volume 14, 2019 - Issue
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Original Research

Long-term icariin treatment ameliorates cognitive deficits via CD4+ T cell-mediated immuno-inflammatory responses in APP/PS1 mice

Tianrui Zhu1 Department of Neurology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, People’s Republic of China
,
Feng Zhang1 Department of Neurology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, People’s Republic of China
,
Heng Li1 Department of Neurology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, People’s Republic of China
,
Yi He2 Department of Neurology, The Second Affiliated Hospital of Xi’an Medical University, Xi’an, Shaanxi 710021, People’s Republic of China
,
Guitao Zhang1 Department of Neurology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, People’s Republic of China
,
Nana Huang1 Department of Neurology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, People’s Republic of China
,
Mingming Guo3 Department of Breast Surgery, The Second Hospital of Shandong University, Jinan, Shandong 250033, People’s Republic of China
&
Xiaohong Li1 Department of Neurology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, People’s Republic of ChinaCorrespondence[email protected]
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Pages 817-826 | Published online: 07 May 2019

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Meiyu Han, Lin Hu & Yang Chen. (2019) Rutaecarpine may improve neuronal injury, inhibits apoptosis, inflammation and oxidative stress by regulating the expression of ERK1/2 and Nrf2/HO-1 pathway in rats with cerebral ischemia-reperfusion injury. Drug Design, Development and Therapy 13, pages 2923-2931.
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Articles from other publishers (12)

Yuqing Liu, Yejun Tan, Zheyu Zhang, Hongli Li, Min Yi, Zhen Zhang, Shan Hui & Weijun Peng. (2023) Neuroimmune mechanisms underlying Alzheimer’s disease: Insights into central and peripheral immune cell crosstalk. Ageing Research Reviews 84, pages 101831.
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Mingyao You, Ping Yuan, Liangqian Li & Hongbei Xu. (2022) HIF-1 signalling pathway was identified as a potential new pathway for Icariin’s treatment against Alzheimer’s disease based on preclinical evidence and bioinformatics. Frontiers in Pharmacology 13.
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Yu Chen, Fu Peng, Ziwei Xing, Junren Chen, Cheng Peng & Dan Li. (2022) Beneficial effects of natural flavonoids on neuroinflammation. Frontiers in Immunology 13.
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Zhuyu Luo, Jingcheng Dong & Jinfeng Wu. (2022) Impact of Icariin and its derivatives on inflammatory diseases and relevant signaling pathways. International Immunopharmacology 108, pages 108861.
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Zhangyang Bi, Wei Zhang & Xiaoyan Yan. (2022) Anti-inflammatory and immunoregulatory effects of icariin and icaritin. Biomedicine & Pharmacotherapy 151, pages 113180.
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Hongxia Yu, Jianhong Shi, Yiyou Lin, Yehui Zhang, Qihang Luo, Suo Huang, Sichen Wang, Jiale Wei, Junhao Huang, Changyu Li & Liting Ji. (2022) Icariin Ameliorates Alzheimer’s Disease Pathology by Alleviating Myelin Injury in 3 × Tg-AD Mice. Neurochemical Research 47:4, pages 1049-1059.
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Baolin Su, Dejin Cheng, Gangyi Chen, Shu Zhang, Liangliang Wang, Xingbo Wu & Shuifu Tang. (2022) Icariin Attenuation of Diabetic Kidney Disease Through Inhibition of Endoplasmic Reticulum Stress via G Protein-Coupled Estrogen Receptors. Journal of Biomedical Nanotechnology 18:2, pages 488-497.
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Rui Zheng, Yang-mei Huang & Qiang Zhou. (2021) Xueshuantong Improves Functions of Lymphatic Ducts and Modulates Inflammatory Responses in Alzheimer’s Disease Mice. Frontiers in Pharmacology 12.
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Yating Wu, Jianbo Zhu, Haifeng Liu & Hailiang Liu. (2021) Licochalcone A improves the cognitive ability of mice by regulating T- and B-cell proliferation. Aging 13:6, pages 8895-8915.
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Katriona L. Hole & Robert J. Williams. (2021) Flavonoids as an Intervention for Alzheimer’s Disease: Progress and Hurdles Towards Defining a Mechanism of Action1. Brain Plasticity 6:2, pages 167-192.
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Xuexia Li, Zhijun He, Chao Wang, Yanjun Liu, Zhifu Shan, Lei Zhang, Qingqing Shi, Caiping Yue, Yitong Lin, Yun Liu, Jiazuan Ni & Xiubo Du. (2020) Effect of Herbal Medicinal Compounds on Alzheimer’s Disease Pathology in APP/PS1 Transgenic Mouse Model. Natural Product Communications 15:8, pages 1934578X2094898.
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Tuo Liang, Zhong-Ming Qian, Ming-Dao Mu, Wing-Ho Yung & Ya Ke. (2020) Brain Hepcidin Suppresses Major Pathologies in Experimental Parkinsonism. iScience 23:7, pages 101284.
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