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Review

Growth hormone (GH)–releasing hormone and GH secretagogues in normal aging: Fountain of Youth or Pool of Tantalus?

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Pages 121-129 | Published online: 07 Mar 2008

Keep up to date with the latest research on this topic with citation updates for this article.

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Nikolaos Samaras, Maria-Aikaterini Papadopoulou, Dimitrios Samaras & Filippo Ongaro. (2014) Off-label use of hormones as an antiaging strategy: a review. Clinical Interventions in Aging 9, pages 1175-1186.
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Articles from other publishers (27)

Daniel G. Blackmore & Michael J. Waters. (2023) The multiple roles of GH in neural ageing and injury. Frontiers in Neuroscience 17.
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Kaitlyn H. Hajdarovic, Doudou Yu & Ashley E. Webb. (2022) Understanding the aging hypothalamus, one cell at a time. Trends in Neurosciences 45:12, pages 942-954.
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Gherta Brill, Iris Manor, Roberta Bril Paroz, Shai Ashkenazi, Shira Cohen, Avivit Golan-Cohen, Ilan Green, Ariel Israel, Shlomo Vinker, Abraham Weizman & Eugene Merzon. (2022) The Association between Somatotropin Therapy and the Risk of SARS-CoV-2 Infection in Children with Short Stature: A Population-Based Cross-Sectional Study. Children 9:12, pages 1844.
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Michihiro Takada, Shin Tanaka, Koh Tanaka, Tamao Tsukie, Masako Tsukamoto‐Yasui, Katsuya Suzuki, Yasushi Noguchi, Akira Imaizumi, Makoto Ishii & Takeshi Ikeuchi. (2022) Effects of an essential amino acid mixture on behavioral and psychological symptoms of dementia and executive function in patients with Alzheimer's disease: A double‐blind, randomized, placebo‐controlled exploratory clinical trial. International Journal of Geriatric Psychiatry 37:9.
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Luh Putu Ratna Sundari & Ni Luh Kadek Alit Arsani. (2022) https://biomedpharmajournal.org/vol15no2/regular-physical-exercise-increase-of-growth-hormone-gh-and-insulin-like-growth-factor-1-igf-1-activity-in-elderly-improve-the-aging-process-and-quality-of-life-a-mini-review/. Biomedical and Pharmacology Journal 15:2, pages 883-890.
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Daniel G. Blackmore, Frederik J. Steyn, Alison Carlisle, Imogen O’Keeffe, King-Year Vien, Xiaoqing Zhou, Odette Leiter, Dhanisha Jhaveri, Jana Vukovic, Michael J. Waters & Perry F. Bartlett. (2021) An exercise “sweet spot” reverses cognitive deficits of aging by growth-hormone-induced neurogenesis. iScience 24:11, pages 103275.
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Péter Judák, Simone Esposito, Gilles Coppieters, Peter Van Eenoo & Koen Deventer. (2021) Doping control analysis of small peptides: A decade of progress. Journal of Chromatography B 1173, pages 122551.
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K. Kinoshita, Rei Otsuka, M. Takada, M. Tsukamoto-Yasui, Y. Nishita, C. Tange, M. Tomida, H. Shimokata, M. Kuzuya, A. Imaizumi & H. Arai. (2020) The Association between Dietary Amino Acid Intake and Cognitive Decline 8 Years Later in Japanese Community-Dwelling Older Adults. The journal of nutrition, health & aging 25:2, pages 165-171.
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Mohamed Hamdy Elkarow & Amr Hamdy. (2020) A Suggested Role of Human Growth Hormone in Control of the COVID-19 Pandemic. Frontiers in Endocrinology 11.
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Charmaine S. Tam, William D. Johnson, Jennifer Rood, Amy L. Heaton & Frank L. Greenway. (2020) Increased Human Growth Hormone After Oral Consumption of an Amino Acid Supplement: Results of a Randomized, Placebo-Controlled, Double-Blind, Crossover Study in Healthy Subjects. American Journal of Therapeutics 27:4, pages e333-e337.
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Junichi Ishida, Masakazu Saitoh, Nicole Ebner, Jochen Springer, Stefan D. Anker & Stephan Haehling. (2020) Growth hormone secretagogues: history, mechanism of action, and clinical development. JCSM Rapid Communications 3:1, pages 25-37.
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I C van Nieuwpoort, M C Vlot, L A Schaap, P Lips & M L Drent. (2018) The relationship between serum IGF-1, handgrip strength, physical performance and falls in elderly men and women. European Journal of Endocrinology 179:2, pages 73-84.
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J. A. Wofford, B. Zollers, L. Rhodes, M. Bell & E. Heinen. (2018) Evaluation of the safety of daily administration of capromorelin in cats. Journal of Veterinary Pharmacology and Therapeutics 41:2, pages 324-333.
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B. Zollers, M. Huebner, G. Armintrout, L. C. Rausch-Derra & L. Rhodes. (2017) Evaluation of the safety in dogs of long-term, daily oral administration of capromorelin, a novel drug for stimulation of appetite. Journal of Veterinary Pharmacology and Therapeutics 40:3, pages 248-255.
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Jann Arends, Ulrich Hacker, David Blum & Stephan von HaehlingStephan von Haehling. 2018. Kachexie bei Tumorerkrankungen. Kachexie bei Tumorerkrankungen 114 132 .
David J. Handelsman. 2016. Endocrinology: Adult and Pediatric. Endocrinology: Adult and Pediatric 441 454.e4 .
T. Y. Xie, S. T. Ngo, J. D. Veldhuis, P. L. Jeffery, L. K. Chopin, M. Tschöp, M. J. Waters, V. Tolle, J. Epelbaum, C. Chen & F. J. Steyn. (2015) Effect of Deletion of Ghrelin- O -Acyltransferase on the Pulsatile Release of Growth Hormone in Mice . Journal of Neuroendocrinology 27:12, pages 872-886.
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A G Ellis, P T Zeglinski, D J Brown, A G Frauman, M Millard & J B Furness. (2014) Pharmacokinetics of the ghrelin agonist capromorelin in a single ascending dose Phase-I safety trial in spinal cord-injured and able-bodied volunteers. Spinal Cord 53:2, pages 103-108.
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Mario Thevis & Wilhelm Schänzer. (2014) Analytical approaches for the detection of emerging therapeutics and non-approved drugs in human doping controls. Journal of Pharmaceutical and Biomedical Analysis 101, pages 66-83.
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Poul F Vestergaard, Mikkel H Vendelbo, Steen B Pedersen, Anders Juul, Steffen Ringgard, Niels Møller, Niels Jessen & Jens O L Jørgensen. (2014) GH signaling in skeletal muscle and adipose tissue in healthy human subjects: impact of gender and age. European Journal of Endocrinology 171:5, pages 623-631.
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Atil Y. Kargi & George R. Merriam. (2013) Diagnosis and treatment of growth hormone deficiency in adults. Nature Reviews Endocrinology 9:6, pages 335-345.
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John E. Morley. (2013) Scientific overview of hormone treatment used for rejuvenation. Fertility and Sterility 99:7, pages 1807-1813.
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E. Gielen, S. Verschueren, T. W. O’Neill, S. R. Pye, M. D. L. O’Connell, D. M. Lee, R. Ravindrarajah, F. Claessens, M. Laurent, K. Milisen, J. Tournoy, M. Dejaeger, F. C. Wu, D. Vanderschueren & S. Boonen. (2012) Musculoskeletal Frailty: A Geriatric Syndrome at the Core of Fracture Occurrence in Older Age. Calcified Tissue International 91:3, pages 161-177.
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Gerhard P. Baumann. (2012) Growth Hormone Doping in Sports: A Critical Review of Use and Detection Strategies. Endocrine Reviews 33:2, pages 155-186.
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Raul M. Luque, Qing Lin, José Córdoba-Chacón, Papasani V. Subbaiah, Thorsten Buch, Ari Waisman, Hugo Vankelecom & Rhonda D. Kineman. (2011) Metabolic Impact of Adult-Onset, Isolated, Growth Hormone Deficiency (AOiGHD) Due to Destruction of Pituitary Somatotropes. PLoS ONE 6:1, pages e15767.
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S. S. Shishkin, K. V. Lisitskaya & I. N. Krakhmaleva. (2011) Biochemical polymorphism of the growth hormone system proteins and its manifestations in human prostate cells. Biochemistry (Moscow) 75:13, pages 1547-1562.
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James W. LarrickAndrew Mendelsohn. (2010) Applied Healthspan Engineering. Rejuvenation Research 13:2-3, pages 265-280.
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