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Review

Klotho, stem cells, and aging

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Pages 1233-1243 | Published online: 04 Aug 2015

Keep up to date with the latest research on this topic with citation updates for this article.

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Xinge Huang, Chuanli Su, Shuyan Chen, Jinlong Teng, Lihua Zhao & Shangjie Chen. (2019) Effect of klotho as an ageing suppressor on insulin signalling cascade in brain of d-galactose mice by Yisui moxibustion. Biotechnology & Biotechnological Equipment 33:1, pages 1343-1353.
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Articles from other publishers (27)

Koranit Thanapairoje, Supanut Junsiritrakhoon, Surasak Wichaiyo, Mohd Azuraidi Osman & Wasu Supharattanasitthi. (2023) Anti-ageing effects of FDA-approved medicines: a focused review. Journal of Basic and Clinical Physiology and Pharmacology 34:3, pages 277-289.
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Francesca Giannuzzi, Silvia Maiullari, Loreto Gesualdo & Fabio Sallustio. (2023) The Mission of Long Non-Coding RNAs in Human Adult Renal Stem/Progenitor Cells and Renal Diseases. Cells 12:8, pages 1115.
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Kristina I. Nesterova, Yelena Yu. Glinka, Valentina N. Perfilova, Alla A. Nesterova & Kamil D. Kaplanov. (2023) Antiaging Klotho Protein as a Prospective Novel Tumor Suppressor. Annals of the Russian academy of medical sciences 78:1, pages 24-44.
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Yuqin Yan & Jun Chen. (2022) Association between serum Klotho concentration and all-cause and cardiovascular mortality among American individuals with hypertension. Frontiers in Cardiovascular Medicine 9.
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Angela Picerno, Francesca Giannuzzi, Claudia Curci, Giuseppe De Palma, Mariagiovanna Di Chiano, Simona Simone, Rossana Franzin, Anna Gallone, Vito Francesco Di Lorenzo, Alessandra Stasi, Giovanni Battista Pertosa, Carlo Sabbà, Loreto Gesualdo & Fabio Sallustio. (2022) The Long Non-coding RNA HOTAIR Controls the Self-renewal, Cell Senescence, and Secretion of Anti-aging Protein α-Klotho in Human Adult Renal Progenitor Cells. Stem Cells 40:10, pages 963-975.
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Gérald J. Prud’homme, Mervé Kurt & Qinghua Wang. (2022) Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations. Frontiers in Aging 3.
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Meera Gupta, Gabriel Orozco, Madhumati Rao, Roberto Gedaly, Hartmut H. Malluche & Javier A. Neyra. (2022) The Role of Alterations in Alpha-Klotho and FGF-23 in Kidney Transplantation and Kidney Donation. Frontiers in Medicine 9.
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Andrea Espuch-Oliver, Héctor Vázquez-Lorente, Lucas Jurado-Fasoli, Tomás de Haro-Muñoz, Irene Díaz-Alberola, María del Señor López-Velez, Teresa de Haro-Romero, Manuel J. Castillo & Francisco J. Amaro-Gahete. (2022) References Values of Soluble α-Klotho Serum Levels Using an Enzyme-Linked Immunosorbent Assay in Healthy Adults Aged 18–85 Years. Journal of Clinical Medicine 11:9, pages 2415.
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Andreas Herrlich. (2022) Interorgan crosstalk mechanisms in disease: the case of acute kidney injury‐induced remote lung injury. FEBS Letters 596:5, pages 620-637.
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Marcella Liciani Franco, Stephany Beyerstedt & Érika Bevilaqua Rangel. (2021) Klotho and Mesenchymal Stem Cells: A Review on Cell and Gene Therapy for Chronic Kidney Disease and Acute Kidney Disease. Pharmaceutics 14:1, pages 11.
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Lianguang Xu, Muhammad Idrees, Myeong-Don Joo, Tabinda Sidrat, Yiran Wei, Seok-Hwan Song, Kyeong-Lim Lee & Il-Keun Kong. (2021) Constitutive Expression of TERT Enhances β-Klotho Expression and Improves Age-Related Deterioration in Early Bovine Embryos. International Journal of Molecular Sciences 22:10, pages 5327.
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Yeshun Wu, Zijun Chen, Jiahao Duan, Kai Huang, Bin Zhu, Ling Yang & Lu Zheng. (2021) Serum Levels of FGF21, β-Klotho, and BDNF in Stable Coronary Artery Disease Patients With Depressive Symptoms: A Cross-Sectional Single-Center Study. Frontiers in Psychiatry 11.
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Marlena Typiak & Agnieszka Piwkowska. (2021) Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy. International Journal of Molecular Sciences 22:2, pages 956.
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Meenakshi Suku, Ashang Luwang Laiva, Fergal J. O’Brien & Michael B. Keogh. (2020) Anti-Ageing Protein β-Klotho Rejuvenates Diabetic Stem Cells for Improved Gene-Activated Scaffold Based Wound Healing. Journal of Personalized Medicine 11:1, pages 4.
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Jie Xu, Lili Zhou & Youhua Liu. (2020) Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies. Frontiers in Pharmacology 11.
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Provvidenza M. Abruzzo, Silvia Canaider, Valeria Pizzuti, Luca Pampanella, Raffaella Casadei, Federica Facchin & Carlo Ventura. (2020) Herb-Derived Products: Natural Tools to Delay and Counteract Stem Cell Senescence. Stem Cells International 2020, pages 1-28.
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Sol Mochón-Benguigui, Almudena Carneiro-Barrera, Manuel J. Castillo & Francisco J. Amaro-Gahete. (2020) Is Sleep Associated with the S-Klotho Anti-Aging Protein in Sedentary Middle-Aged Adults? The FIT-AGEING Study. Antioxidants 9:8, pages 738.
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Barbara Infante, Rossana Franzin, Desirèe Madio, Martina Calvaruso, Annamaria Maiorano, Fabio Sangregorio, Giuseppe Stefano Netti, Elena Ranieri, Loreto Gesualdo, Giuseppe Castellano & Giovanni Stallone. (2020) Molecular Mechanisms of AKI in the Elderly: From Animal Models to Therapeutic Intervention. Journal of Clinical Medicine 9:8, pages 2574.
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Rossana Franzin, Alessandra Stasi, Marco Fiorentino, Giovanni Stallone, Vincenzo Cantaluppi, Loreto Gesualdo & Giuseppe Castellano. (2020) Inflammaging and Complement System: A Link Between Acute Kidney Injury and Chronic Graft Damage. Frontiers in Immunology 11.
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Peng Li, Mingjun Shi, Jenny Maique, Joy Shaffer, Shirley Yan, Orson W. Moe & Ming Chang Hu. (2020) Beclin 1/Bcl-2 complex-dependent autophagy activity modulates renal susceptibility to ischemia-reperfusion injury and mediates renoprotection by Klotho. American Journal of Physiology-Renal Physiology 318:3, pages F772-F792.
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Behrouz Baghaiee, Maliheh Barzegari, Mohammad Hossein Sadeghi Zali & Mehdi Hakimi. (2019) Effect of Exercise Training and Aging on Klotho Signaling in the Heart. Journal of Clinical Research in Paramedical Sciences 8:2.
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Mujib Ullah & Zhongjie Sun. (2019) Klotho Deficiency Accelerates Stem Cells Aging by Impairing Telomerase Activity. The Journals of Gerontology: Series A 74:9, pages 1396-1407.
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Felipe Salech, Lorena Varela-Nallar, Sebastián B Arredondo, Daniel B Bustamante, Gabriela A Andaur, Rodrigo Cisneros, Daniela P Ponce, Patricia Ayala, Nibaldo C Inestrosa, José L Valdés, María I. Behrens & Andrés Couve. (2019) Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus. The Journals of Gerontology: Series A 74:7, pages 1043-1051.
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Buhui Liu, Yue Tu, Weiming He, Yinglu Liu, Wei Wu, Qijun Fang, Haitao Tang, Renmao Tang, Ziyue Wan, Wei Sun & Yigang Wan. (2018) Hyperoside attenuates renal aging and injury induced by D-galactose via inhibiting AMPK-ULK1 signaling-mediated autophagy. Aging 10:12, pages 4197-4212.
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Helen A. Rowland, Nigel M. Hooper & Katherine A. B. Kellett. (2018) Modelling Sporadic Alzheimer’s Disease Using Induced Pluripotent Stem Cells. Neurochemical Research 43:12, pages 2179-2198.
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Fangfang Bi, Fang Chen, Yanning Li, Ai Wei & Wangsen Cao. (2018) Klotho preservation by Rhein promotes toll-like receptor 4 proteolysis and attenuates lipopolysaccharide-induced acute kidney injury. Journal of Molecular Medicine 96:9, pages 915-927.
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Stefania Dalise, Loredana Cavalli, Harmanvir Ghuman, Brendon Wahlberg, Madeline Gerwig, Carmelo Chisari, Fabrisia Ambrosio & Michel Modo. (2017) Biological effects of dosing aerobic exercise and neuromuscular electrical stimulation in rats. Scientific Reports 7:1.
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