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Review

Hypoglycemia: a review of definitions used in clinical trials evaluating antihyperglycemic drugs for diabetes

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Pages 291-296 | Published online: 23 May 2017

Keep up to date with the latest research on this topic with citation updates for this article.

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Elias Bekka & Florian Eyer. (2022) Dose-related hypoglycemia in venlafaxine poisoning: a retrospective cohort study. Clinical Toxicology 60:12, pages 1336-1344.
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Yongjing Ju, Duzhen Zhang & Junyi Yang. (2022) Dasiglucagon for treating severe hypoglycemia in patients with diabetes. Expert Review of Clinical Pharmacology 15:7, pages 799-803.
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Xiang-Ning Li, Yin-Shi Kan, Hong-Yuan Liu, Juan Pang, Yu-Ying He, Lin Liu, Yan Zou, Ning Zhang & Yu Zhang. (2023) Prevalence and contributing factors of impaired awareness of hypoglycemia in patients with type 2 diabetes: a meta-analysis. Acta Diabetologica 60:9, pages 1155-1169.
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Sergio Diez Alvarez, Antoni Fellas, Derek Santos, Dean Sculley, Katie Wynne, Shamasunder Acharya, Pooshan Navathe, Xavier Girones & Andrea Coda. (2023) The Clinical Impact of Flash Glucose Monitoring—a Digital Health App and Smartwatch Technology in Patients With Type 2 Diabetes: Scoping Review. JMIR Diabetes 8, pages e42389.
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Cemile Bozdemir-Ozel, Hülya Arikan, Ebru Çalik-Kutukcu, Beyza Nur Karaduz, Deniz Inal-Ince, Giray Kabakci & Selçuk Dagdelen. (2022) Energy expenditure and glucose-lowering effect of different exercise modalities in diabetes mellitus. Physiotherapy 117, pages 97-103.
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Wajd Alkabbani, Colleen J Maxwell, Ruth Ann Marrie, Suzanne L Tyas, Iliana C Lega & John-Michael Gamble. (2022) Hypoglycaemia and the risk of dementia: a population-based cohort study using exposure density sampling. International Journal of Epidemiology.
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Agnieszka Przezak, Weronika Bielka & Piotr Molęda. (2022) Fear of hypoglycemia—An underestimated problem. Brain and Behavior 12:7.
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Shuang Li, Yehui Li, Lu Zhang, Yaxin Bi, Yan Zou, Lin Liu, Hong Zhang, Yuan Yuan, Weijuan Gong & Yu Zhang. (2022) Impact of fear of hypoglycaemia on self-management in patients with type 2 diabetes mellitus: structural equation modelling. Acta Diabetologica 59:5, pages 641-650.
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Xueyao Yin, WeiFen Zhu, Chao Liu, Huilan Yao, Jiaxing You, Yixin Chen, Xiaofang Ying & Lin Li. (2022) Association of continuous glucose monitoring-derived time in range with major amputation risk in diabetic foot osteomyelitis patients undergoing amputation. Therapeutic Advances in Endocrinology and Metabolism 13, pages 204201882210993.
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I. Ibrahim, R. Macatangay, C. Y. Chai, C. M. Khoo & M. Mahadevan. (2021) 24-hr observation unit is safe location for rapid glucose control in uncomplicated severe hyperglycaemia. BMC Emergency Medicine 21:1.
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Yedidya Saiman & Nadim Mahmud. (2021) Hypoglycemia is an early, independent predictor of bacteremia and in-hospital death in patients with cirrhosis. European Journal of Gastroenterology & Hepatology 33:1S, pages e693-e699.
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Richard Ian Gregory Holt, Giorgos Dritsakis, Katharine Barnard-Kelly, Kerensa Thorne, Amy Whitehead, Lauren Cohen, Elizabeth Dixon, Mayank Patel, Philip Newland-Jones, Mark Green, Helen Partridge, Suvitesh Luthra, Sunil Ohri, Kareem Salhiyyah, Joanne Lord, John Niven & Andrew Cook. (2021) The Optimising Cardiac Surgery ouTcOmes in People with diabeteS (OCTOPuS) randomised controlled trial to evaluate an outpatient pre-cardiac surgery diabetes management intervention: a study protocol. BMJ Open 11:6, pages e050919.
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Huda Y. Almomani, Carlos Rodriguez Pascual, Sayer I. Al-Azzam & Keivan Ahmadi. (2021) Randomised controlled trial of pharmacist-led patient counselling in controlling hypoglycaemic attacks in older adults with type 2 diabetes mellitus (ROSE-ADAM): A study protocol of the SUGAR intervention. Research in Social and Administrative Pharmacy 17:5, pages 885-893.
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René Rodríguez-Gutiérrez, Alejandro Salcido-Montenegro, José Gerardo González-González & Rozalina G McCoy. (2021) Variation in hypoglycemia ascertainment and report in type 2 diabetes observational studies: a meta-epidemiological study. BMJ Open Diabetes Research & Care 9:1, pages e001906.
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Rébecca Bienvenot, Marie‐Aude Sirveaux, Phi‐Linh Nguyen‐Thi, Laurent Brunaud & Didier Quilliot. (2021) Symptomatic Hypoglycemia After Gastric Bypass: Incidence and Predictive Factors in a Cohort of 1,138 Consecutive Patients. Obesity 29:4, pages 681-688.
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Surendra Kumar. (2021) Comparison of safety and efficacy of glimepiride-metformin and vildagliptin- metformin treatment in newly diagnosed type 2 diabetic patients. Indian Journal of Endocrinology and Metabolism 25:4, pages 326.
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Steven Setford, Stuart Phillips & Mike Grady. (2019) Evidence From a Long-Term, Systematic Post-Market Surveillance Program: Clinical Performance of a Hematocrit-Insensitive Blood Glucose Test Strip. Journal of Diabetes Science and Technology 15:1, pages 67-75.
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Xin Qi, Minh N. Ta & Richard F. Tester. (2020) Savoury cracker development for blood glucose control and management. Bioactive Carbohydrates and Dietary Fibre 24, pages 100249.
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Anthony Staples, Nicolas R. Thompson & Manikum Moodley. (2020) Pediatric-Onset Postural Orthostatic Tachycardia Syndrome in a Single Tertiary Care Center. Journal of Child Neurology 35:8, pages 526-535.
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Muhammad Muneer. 2021. Diabetes: from Research to Clinical Practice. Diabetes: from Research to Clinical Practice 43 69 .
Sanaz Kamalinia, Robert G. Josse, Patrick J. Donio, Lindsay Leduc, Baiju R. Shah & Sheldon W. Tobe. (2019) Risk of any hypoglycaemia with newer antihyperglycaemic agents in patients with type 2 diabetes: A systematic review and meta‐analysis. Endocrinology, Diabetes & Metabolism 3:1.
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Jana Urbanova, Ludmila Brunerova & Jan Broz. (2019) Hypoglycemia and antihyperglycemic treatment in adult MODY patients – A systematic review of literature. Diabetes Research and Clinical Practice 158, pages 107914.
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Johan Farngren & Bo Ahrén. (2019) Incretin-based medications (GLP-1 receptor agonists, DPP-4 inhibitors) as a means to avoid hypoglycaemic episodes. Metabolism 99, pages 25-31.
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Hassan Ghasemi, Zolfaghar Sabati, Hamid Ghaedi, Zaker Salehi & Behnam Alipoor. (2019) Circular RNAs in β-cell function and type 2 diabetes-related complications: a potential diagnostic and therapeutic approach. Molecular Biology Reports 46:5, pages 5631-5643.
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Alice König, Bettina Schwarzinger, Verena Stadlbauer, Peter Lanzerstorfer, Marcus Iken, Clemens Schwarzinger, Peter Kolb, Stephan Schwarzinger, Katharina Mörwald, Susanne Brunner, Otmar Höglinger, Daniel Weghuber & Julian Weghuber. (2019) Guava (Psidium guajava) Fruit Extract Prepared by Supercritical CO2 Extraction Inhibits Intestinal Glucose Resorption in a Double-Blind, Randomized Clinical Study. Nutrients 11:7, pages 1512.
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Brian M. Frier, Alexandria Ratzki‐Leewing & Stewart B. Harris. (2019) Reporting of hypoglycaemia in clinical trials of basal insulins: A need for consensus. Diabetes, Obesity and Metabolism 21:7, pages 1529-1542.
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K. Mattishent & Y.K. Loke. (2018) Detection of asymptomatic drug-induced hypoglycemia using continuous glucose monitoring in older people – Systematic review. Journal of Diabetes and its Complications 32:8, pages 805-812.
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Linong Ji, Zhengnan Gao, Bimin Shi, Rongwen Bian, Fuzai Yin, Wuyan Pang, Hong Gao & Nan Cui. (2018) Safety and Efficacy of High Versus Standard Starting Doses of Insulin Glargine in Overweight and Obese Chinese Individuals with Type 2 Diabetes Mellitus Inadequately Controlled on Oral Antidiabetic Medications (Beyond VII): Study Protocol for a Randomized Controlled Trial. Advances in Therapy 35:6, pages 864-874.
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Fei-Fei Shang, Suxin Luo, Xiaoxue Liang & Yong Xia. (2018) Alterations of circular RNAs in hyperglycemic human endothelial cells. Biochemical and Biophysical Research Communications 499:3, pages 551-555.
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Emma J. Stevenson, Anthony Watson, Stephan Theis, Anja Holz, Liam D. Harper & Mark Russell. (2017) A comparison of isomaltulose versus maltodextrin ingestion during soccer-specific exercise. European Journal of Applied Physiology 117:11, pages 2321-2333.
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