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Clinical Epidemiology Volume 5, 2013 - Issue
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Methodology

Use of existing data sources in clinical epidemiology: Finnish health care registers in Alzheimer’s disease research – the Medication use among persons with Alzheimer’s disease (MEDALZ-2005) study

Anna-Maija Tolppanen1 Institute of Clinical Medicine – Neurology, University of Eastern Finland, Kuopio, FinlandCorrespondence[email protected]
,
Heidi Taipale2 Kuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland;3 School of Pharmacy, University of Eastern Finland, Kuopio, Finland
,
Marjaana Koponen2 Kuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland;3 School of Pharmacy, University of Eastern Finland, Kuopio, Finland
,
Piia Lavikainen2 Kuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland
,
Antti Tanskanen4 Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden;5 National Institute for Health and Welfare, Helsinki, Finland
,
Jari Tiihonen4 Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden;5 National Institute for Health and Welfare, Helsinki, Finland;6 University of Eastern Finland, Department of Forensic Psychiatry, Niuvanniemi Hospital, Kuopio, Finland
&
Sirpa Hartikainen2 Kuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland;3 School of Pharmacy, University of Eastern Finland, Kuopio, Finland
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Pages 277-285 | Published online: 07 Aug 2013

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Pasi Lampela, Anna-Maija Tolppanen, Antti Tanskanen, Jari Tiihonen, Piia Lavikainen, Sirpa Hartikainen & Heidi Taipale. (2017) Use of antidementia drugs and risk of pneumonia in older persons with Alzheimer’s disease. Annals of Medicine 49:3, pages 230-239.
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Tommi Härkänen, Juha Karvanen, Hanna Tolonen, Risto Lehtonen, Kari Djerf, Teppo Juntunen & Seppo Koskinen. (2016) Systematic handling of missing data in complex study designs – experiences from the Health 2000 and 2011 Surveys. Journal of Applied Statistics 43:15, pages 2772-2790.
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Articles from other publishers (37)

Atte Rahkonen, Heidi Taipale, Marjaana Koponen, Sirpa Hartikainen, Anna-Maija Tolppanen, Antti Tanskanen & Miia Tiihonen. (2023) The Cumulative Use of Muscle Relaxants and the Risk of Alzheimer’s Disease: A Nationwide Case-Control Study. Journal of Alzheimer's Disease 91:4, pages 1283-1290.
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Xiao-Wei Feng, Maryam Hadizadeh, Lin-Hong Zheng & Wei-Han Li. (2022) A Bibliometric and Visual Analysis of Exercise Intervention Publications for Alzheimer’s Disease (1998–2021). Journal of Clinical Medicine 11:19, pages 5903.
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Blair Rajamaki, Sirpa Hartikainen & Anna-Maija Tolppanen. (2021) The effect of comorbidities on survival in persons with Alzheimer’s disease: a matched cohort study. BMC Geriatrics 21:1.
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Anna-Maija Tolppanen, Heidi Taipale, Marjaana Koponen, Jari Tiihonen & Sirpa Hartikainen. (2020) Causes of death in a nationwide cohort of community-dwellers with Alzheimer’s disease. BMC Geriatrics 20:1.
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Blair Rajamaki, Marjaana Koponen, Sirpa Hartikainen & Anna-Maija Tolppanen. (2020) Length of hospital stay after hip fracture and readmission rates of persons with and without Alzheimer’s disease: a matched cohort study. BMC Geriatrics 20:1.
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Gwendolyn A R Donley, Eija Lönnroos, Tomi-Pekka Tuomainen & Jussi Kauhanen. (2018) Association of childhood stress with late-life dementia and Alzheimer’s disease: the KIHD study. European Journal of Public Health 28:6, pages 1069-1073.
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Heidi Taipale, Marjaana Koponen, Antti Tanskanen, Piia Lavikainen, Reijo Sund, Jari Tiihonen, Sirpa Hartikainen & Anna-Maija Tolppanen. (2017) Risk of head and traumatic brain injuries associated with antidepressant use among community-dwelling persons with Alzheimer’s disease: a nationwide matched cohort study. Alzheimer's Research & Therapy 9:1.
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Heidi Taipale, Anna-Maija Tolppanen, Miia Tiihonen, Antti Tanskanen, Jari Tiihonen & Sirpa Hartikainen. (2017) No Association Between Proton Pump Inhibitor Use and Risk of Alzheimer’s Disease. American Journal of Gastroenterology 112:12, pages 1802-1808.
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A. Gallini, F. Moisan, G. Maura, L. Carcaillon-Bentata, E. Leray, J. Haesebaert, A. Bruandet, E. Moutengou, L. Luciano, A. Weill, B. Marin & V. Gardette. (2017) Identification des maladies neurodégénératives dans les bases de données médicoadministratives en France : revue systématique de la littérature. Revue d'Épidémiologie et de Santé Publique 65, pages S183-S197.
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Antti Tanskanen, Heidi Taipale, Marjaana Koponen, Anna-Maija Tolppanen, Sirpa Hartikainen, Riitta Ahonen & Jari Tiihonen. (2017) Drug exposure in register-based research—An expert-opinion based evaluation of methods. PLOS ONE 12:9, pages e0184070.
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V. Tapiainen, S. Hartikainen, H. Taipale, J. Tiihonen & A.-M. Tolppanen. (2020) Hospital-treated mental and behavioral disorders and risk of Alzheimer's disease: A nationwide nested case-control study. European Psychiatry 43, pages 92-98.
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Maria K Luojus, Soili M Lehto, Tommi Tolmunen, Anna-Katharine Brem, Eija Lönnroos & Jussi Kauhanen. (2017) Self-reported sleep disturbance and incidence of dementia in ageing men. Journal of Epidemiology and Community Health 71:4, pages 329-335.
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Anna-Maija Tolppanen, Ari Voutilainen, Heidi Taipale, Antti Tanskanen, Piia Lavikainen, Marjaana Koponen, Jari Tiihonen & Sirpa Hartikainen. (2017) Regional changes in psychotropic use among Finnish persons with newly diagnosed Alzheimer’s disease in 2005-2011. PLOS ONE 12:3, pages e0173450.
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Maija PT Ylilauri, Sari Voutilainen, Eija Lönnroos, Jaakko Mursu, Heli EK Virtanen, Timo T Koskinen, Jukka T Salonen, Tomi-Pekka Tuomainen & Jyrki K Virtanen. (2017) Association of dietary cholesterol and egg intakes with the risk of incident dementia or Alzheimer disease: the Kuopio Ischaemic Heart Disease Risk Factor Study ,. The American Journal of Clinical Nutrition 105:2, pages 476-484.
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Marjaana Koponen, Heidi Taipale, Piia Lavikainen, Antti Tanskanen, Jari Tiihonen, Anna-Maija Tolppanen, Riitta Ahonen & Sirpa Hartikainen. (2017) Risk of Mortality Associated with Antipsychotic Monotherapy and Polypharmacy Among Community-Dwelling Persons with Alzheimer’s Disease. Journal of Alzheimer's Disease 56:1, pages 107-118.
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Marco Canevelli, Federica Quarata, Francesca Remiddi, Flaminia Lucchini, Eleonora Lacorte, Nicola Vanacore, Giuseppe Bruno & Matteo Cesari. (2017) Sex and gender differences in the treatment of Alzheimer’s disease: A systematic review of randomized controlled trials. Pharmacological Research 115, pages 218-223.
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Daniela C. Moga, Heidi Taipale, Anna-Maija Tolppanen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Qishan Wu, Gregory A. Jicha & Danijela Gnjidic. (2016) A Comparison of Sex Differences in Psychotropic Medication Use in Older People with Alzheimer’s Disease in the US and Finland. Drugs & Aging 34:1, pages 55-65.
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Arto Puranen, Heidi Taipale, Marjaana Koponen, Antti Tanskanen, Anna-Maija Tolppanen, Jari Tiihonen & Sirpa Hartikainen. (2017) Incidence of antidepressant use in community-dwelling persons with and without Alzheimer's disease: 13-year follow-up. International Journal of Geriatric Psychiatry 32:1, pages 94-101.
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Anna-Maija Tolppanen, Heidi Taipale, Antti Tanskanen, Jari Tiihonen & Sirpa Hartikainen. (2016) Comparison of predictors of hip fracture and mortality after hip fracture in community-dwellers with and without Alzheimer’s disease – exposure-matched cohort study. BMC Geriatrics 16:1.
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Anna-Maija Tolppanen, Marjaana Koponen, Antti Tanskanen, Piia Lavikainen, Reijo Sund, Jari Tiihonen, Sirpa Hartikainen & Heidi Taipale. (2016) Antipsychotic Use and Risk of Hospitalization or Death Due to Pneumonia in Persons With and Those Without Alzheimer Disease. Chest 150:6, pages 1233-1241.
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Heidi Taipale, Marjaana Koponen, Antti Tanskanen, Anna-Maija Tolppanen, Jari Tiihonen & Sirpa Hartikainen. (2016) Drug use in persons with and without Alzheimer's disease aged 90 years or more. Age and Ageing 45:6, pages 900-904.
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Miia Tiihonen, Heidi Taipale, Antti Tanskanen, Jari Tiihonen & Sirpa Hartikainen. (2016) Incidence and Duration of Cumulative Bisphosphonate Use among Community-Dwelling Persons with or without Alzheimer’s Disease. Journal of Alzheimer's Disease 52:1, pages 127-132.
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Anna-Maija Tolppanen, Riitta Ahonen, Marjaana Koponen, Piia Lavikainen, Maija Purhonen, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Miia Tiihonen & Sirpa Hartikainen. (2016) Month and Season of Birth as a Risk Factor for Alzheimer’s Disease: A Nationwide Nested Case-control Study. Journal of Preventive Medicine and Public Health 49:2, pages 134-138.
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Heidi Taipale, Maija Purhonen, Anna-maija Tolppanen, Antti Tanskanen, Jari Tiihonen & Sirpa Hartikainen. (2015) Hospital care and drug costs from five years before until two years after the diagnosis of Alzheimer’s disease in a Finnish nationwide cohort. Scandinavian Journal of Public Health 44:2, pages 150-158.
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Laura Saarelainen, Heidi Taipale, Marjaana Koponen, Antti Tanskanen, Anna-Maija Tolppanen, Jari Tiihonen & Sirpa Hartikainen. (2015) The Incidence of Benzodiazepine and Related Drug Use in Persons with and without Alzheimer’s Disease. Journal of Alzheimer's Disease 49:3, pages 809-818.
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Antti Tanskanen, Heidi Taipale, Marjaana Koponen, Anna-Maija Tolppanen, Sirpa Hartikainen, Riitta Ahonen & Jari Tiihonen. (2015) From prescription drug purchases to drug use periods – a second generation method (PRE2DUP). BMC Medical Informatics and Decision Making 15:1.
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Heidi Taipale, Hanna Vuorikari, Antti Tanskanen, Marjaana Koponen, Jari Tiihonen, Raimo Kettunen & Sirpa Hartikainen. (2015) Prevalence of Drug Combinations Increasing Bleeding Risk Among Warfarin Users With and Without Alzheimer’s Disease. Drugs & Aging 32:11, pages 937-945.
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Marjaana Koponen, Heidi Taipale, Antti Tanskanen, Anna-Maija Tolppanen, Jari Tiihonen, Riitta Ahonen & Sirpa Hartikainen. (2015) Long-term use of antipsychotics among community-dwelling persons with Alzheimer׳s disease: A nationwide register-based study. European Neuropsychopharmacology 25:10, pages 1706-1713.
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Jari Heiskanen, Sirpa Hartikainen, Risto P. Roine & Anna-Maija Tolppanen. (2015) 30-Day Mortality after Cardiovascular Events in Persons with or without Alzheimer’s Disease. Journal of Alzheimer's Disease 48:1, pages 241-249.
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Anna‐Maija Tolppanen, Heidi Taipale, Timo Purmonen, Marjaana Koponen, Hilkka Soininen & Sirpa Hartikainen. (2014) Hospital admissions, outpatient visits and healthcare costs of community‐dwellers with Alzheimer's disease. Alzheimer's & Dementia 11:8, pages 955-963.
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Heidi Taipale, Marjaana Koponen, Antti Tanskanen, Anna-Maija Tolppanen, Jari Tiihonen & Sirpa Hartikainen. (2015) Long-term use of benzodiazepines and related drugs among community-dwelling individuals with and without Alzheimer’s disease. International Clinical Psychopharmacology 30:4, pages 202-208.
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Anne Leinonen, Marjaana Koponen & Sirpa Hartikainen. (2015) Systematic Review: Representativeness of Participants in RCTs of Acetylcholinesterase Inhibitors. PLOS ONE 10:5, pages e0124500.
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Antti Tanskanen, Heidi Taipale, Marjaana Koponen, Anna-Maija Tolppanen, Sirpa Hartikainen, Riitta Ahonen & Jari Tiihonen. (2014) From prescriptions to drug use periods - things to notice. BMC Research Notes 7:1.
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Tommi Härkänen, Risto Kaikkonen, Esa Virtala & Seppo Koskinen. (2014) Inverse probability weighting and doubly robust methods in correcting the effects of non-response in the reimbursed medication and self-reported turnout estimates in the ATH survey. BMC Public Health 14:1.
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Sanna Torvinen-Kiiskinen, Heidi Taipale, Antti Tanskanen, Jari Tiihonen & Sirpa Hartikainen. (2014) Concomitant Use of Acetylcholine Esterase Inhibitors and Urinary Antispasmodics Among Finnish Community-Dwelling Persons With Alzheimer Disease. Journal of Clinical Psychopharmacology 34:6, pages 722-727.
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Heidi Taipale, Marjaana Koponen, Antti Tanskanen, Anna-Maija Tolppanen, Jari Tiihonen & Sirpa Hartikainen. (2014) High prevalence of psychotropic drug use among persons with and without Alzheimer׳s disease in Finnish nationwide cohort. European Neuropsychopharmacology 24:11, pages 1729-1737.
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Heidi Taipale, Marjaana Koponen, Antti Tanskanen, Anna-Maija Tolppanen, Jari Tiihonen & Sirpa Hartikainen. (2014) Antipsychotic Doses Among Community-Dwelling Persons With Alzheimer Disease in Finland. Journal of Clinical Psychopharmacology 34:4, pages 435-440.
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