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Cancer Management and Research Volume 11, 2019 - Issue
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Original Research

Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway

Liubo Chen1 Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, [email protected]; [email protected];2 Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, [email protected]; [email protected]
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Kai Jiang1 Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, [email protected]; [email protected];2 Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, [email protected]; [email protected]
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Haiyan Chen1 Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, [email protected]; [email protected];3 Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
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Yang Tang1 Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, [email protected]; [email protected];2 Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, [email protected]; [email protected]
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Xinyi Zhou1 Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, [email protected]; [email protected];2 Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, [email protected]; [email protected]
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Yinuo Tan1 Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, [email protected]; [email protected];4 Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
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Ying Yuan1 Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, [email protected]; [email protected];4 Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
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Qian Xiao1 Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, [email protected]; [email protected];2 Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, [email protected]; [email protected]Correspondence[email protected] [email protected]
&
Kefeng Ding1 Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, [email protected]; [email protected];2 Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, [email protected]; [email protected]Correspondence[email protected] [email protected]
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Pages 95-105 | Published online: 20 Dec 2018

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Mohammad A. Alfhili & Jawaher Alsughayyir. (2023) Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death. Xenobiotica 53:5, pages 445-453.
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Zi Wayne Sin, Chakrabhavi Dhananjaya Mohan, Arunachalam Chinnathambi, Chandramohan Govindasamy, Shobith Rangappa, Kanchugarakoppal S. Rangappa, Young Yun Jung & Kwang Seok Ahn. (2022) Leelamine Exerts Antineoplastic Effects in Association with Modulating Mitogen‑Activated Protein Kinase Signaling Cascade. Nutrition and Cancer 74:9, pages 3375-3387.
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Articles from other publishers (19)

Xuewei Xia, Yulin Wu, Zexin Chen, Danyi Du, Xiaodan Chen, Rongxin Zhang, Jun Yan, Io Nam Wong & Riming Huang. (2024) Colon cancer inhibitory properties of Caulerpa lentillifera polysaccharide and its molecular mechanisms based on three-dimensional cell culture model. International Journal of Biological Macromolecules 267, pages 131574.
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Na Young Kim, Chakrabhavi Dhananjaya Mohan, Gautam Sethi & Kwang Seok Ahn. (2024) Cannabidiol activates MAPK pathway to induce apoptosis, paraptosis, and autophagy in colorectal cancer cells. Journal of Cellular Biochemistry 125:4.
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Kening Sun, Ping Chen, Liang Zhang, Zhidong Lu & Qunhua Jin. (2024) Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway. Acta Pharmaceutica 74:1, pages 101-115.
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Huiyun Wei, Yingying Zhang, Yilin Jia, Xunan Chen, Tengda Niu, Aniruddha Chatterjee, Pengxing He & Guiqin Hou. (2024) Heat shock protein 90: biological functions, diseases, and therapeutic targets. MedComm 5:2.
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Chun-Wen Su, Shao-Hsuan Kao, Yi-Tzu Chen, Yi-Hsien Hsieh, Wei-En Yang, Meng-Ying Tsai, Chiao-Wen Lin & Shun-Fa Yang. (2024) Curcumin Analog L48H37 Induces Apoptosis in Human Oral Cancer Cells by Activating Caspase Cascades and Downregulating the Inhibitor of Apoptosis Proteins through JNK/p38 Signaling. The American Journal of Chinese Medicine 52:02, pages 565-581.
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Yexing Tao, Rong Li, Lin Xiang, Xiwen Zhang, Ruiting Liu, Ting Wu, Siyi Pan & Xiaoyun Xu. (2023) Inhibitory effects of Pericarpium Citri Reticulatae ‘Chachi’ flavonoid extracts during storage against NSCLC in vivo and in vitro. Journal of Functional Foods 110, pages 105840.
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Yonglin Yi, Zhengang Qiu, Zifu Yao, Anqi Lin, Yimin Qin, Ruizhan Sha, Ting Wei, Yanru Wang, Quan Cheng, Jian Zhang, Peng Luo & Weitao Shen. (2022) CAMSAP1 Mutation Correlates With Improved Prognosis in Small Cell Lung Cancer Patients Treated With Platinum-Based Chemotherapy. Frontiers in Cell and Developmental Biology 9.
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Zhu Yue Lin, Qu Zhen Yun, Liu Wu, Tian Wen Zhang & Tang Ze Yao. (2021) Pharmacological basis and new insights of deguelin concerning its anticancer effects. Pharmacological Research 174, pages 105935.
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Yu Peng, Hongxun Tao, Yuanyuan Yang, Yuanqing Gao, Hui Ren, Jing Hu, Zhiyong Chen & Ye Li. (2021) Chemical compositions, pharmacological activities, quality control studies of Erycibes plants, and the development of their substitutes . Phytotherapy Research 35:8, pages 4049-4074.
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Manzoor A. Mir, Umar Mehraj & Bashir A. Sheikh. (2021) Recent Advances in Chemotherapeutic Implications of Deguelin: A Plant- Derived Retinoid. The Natural Products Journal 11:2, pages 169-181.
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Hardeep Singh Tuli, Sonam Mittal, Mariam Loka, Vaishali Aggarwal, Diwakar Aggarwal, Akshara Masurkar, Ginpreet Kaur, Mehmet Varol, Katrin Sak, Manoj Kumar, Gautam Sethi & Anupam Bishayee. (2021) Deguelin targets multiple oncogenic signaling pathways to combat human malignancies. Pharmacological Research 166, pages 105487.
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YaJie Li, Yan Zhao, Yi Li, XiaoYi Zhang, Chao Li, NiYa Long, XueShu Chen, LiYa Bao, JianJiang Zhou & Yuan Xie. (2021) Gastrin-17 induces gastric cancer cell epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway. Journal of Physiology and Biochemistry 77:1, pages 93-104.
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Khayal Al-Khayal, Mansoor-Ali Vaali-Mohammed, Mohammed Elwatidy, Thamer Bin Traiki, Omar Al-Obeed, Mohammad Azam, Zahid Khan, Maha Abdulla & Rehan Ahmad. (2020) A novel coordination complex of platinum (PT) induces cell death in colorectal cancer by altering redox balance and modulating MAPK pathway. BMC Cancer 20:1.
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Fatemeh Yarmohammadi, A. Wallace Hayes, Nahid Najafi & Gholamreza Karimi. (2020) The protective effect of natural compounds against rotenone‐induced neurotoxicity. Journal of Biochemical and Molecular Toxicology 34:12.
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Thadeu E.M.M. Costa, Nulgumnalli Manjunathaiah Raghavendra & Carmen Penido. (2020) Natural heat shock protein 90 inhibitors in cancer and inflammation. European Journal of Medicinal Chemistry 189, pages 112063.
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Feng Gao, Xinfang Yu, Ming Li, Li Zhou, Wenbin Liu, Wei Li & Haidan Liu. (2020) Deguelin suppresses non-small cell lung cancer by inhibiting EGFR signaling and promoting GSK3β/FBW7-mediated Mcl-1 destabilization. Cell Death & Disease 11:2.
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Binlong Zhong, Deyao Shi, Fashuai Wu, Shangyu Wang, Hongzhi Hu, Cheng Cheng, Xiangcheng Qing, Xin Huang, Xueying Luo, Zhicai Zhang & Zengwu Shao. (2019) Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma. Cell Death & Disease 10:10.
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Yi Jer Tan, Yeuan Ting Lee, Sven H. Petersen, Gurjeet Kaur, Koji Kono, Soo Choon Tan, Amin M. S. Abdul Majid & Chern Ein Oon. (2019) BZD9L1 sirtuin inhibitor as a potential adjuvant for sensitization of colorectal cancer cells to 5-fluorouracil. Therapeutic Advances in Medical Oncology 11, pages 175883591987897.
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