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Original Research

Knockdown of PKM2 suppresses tumor progression in human cervical cancer by modulating epithelial–mesenchymal transition via Wnt/β-catenin signaling

Yanzhu Lin1 Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China, [email protected]

Fanqing Meng2 Department of Anesthesiology, Jinan Maternity and Child Care Hospital, Jinan, China

Zhiyuan Lu3 Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

Kai Chen1 Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China, [email protected]

Yalan Tao1 Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China, [email protected]

Yi Ouyang1 Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China, [email protected]

Xinping Cao1 Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China, [email protected]Correspondence[email protected]

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Pages 4191-4202 | Published online: 04 Oct 2018

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Qun Liu, Xiuhan Chen, Yurong Tan, Jiao Liu, Mingya Zhu, Delin Li, Yijie Zhou, Tiane Zhang & Qiao zhi Yin. (2024) Natural products as glycolytic inhibitors for cervical cancer treatment: A comprehensive review. Biomedicine & Pharmacotherapy 175, pages 116708.
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Aihua Xu, Yang Yang, Yang Shao, Manyu Jiang, Yongxin Sun & Bo Feng. (2023) FHL2 regulates microglia M1/M2 polarization after spinal cord injury via PARP14-depended STAT1/6 pathway. International Immunopharmacology 124, pages 110853.
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Yawei He, Wanjing Chen, Liang Yu, Yanwei Liu, Yunsheng Cheng, Xianghua Li & Gang Yu. (2023) FOXA2 suppresses PKM2 transcription and affects the Wnt/β‐catenin activity to block aerobic glycolysis in thyroid carcinoma . Clinical and Experimental Pharmacology and Physiology 50:7, pages 561-572.
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Min Su, Shidong Shan, Yang Gao, Mengyuan Dai, Hua Wang, Can He, Mengna Zhao, Ziyan Liang, Shimeng Wan, Junyuan Yang & Hongbing Cai. (2023) 2‐Deoxy‐D ‐glucose simultaneously targets glycolysis and Wnt/β‐catenin signaling to inhibit cervical cancer progression . IUBMB Life 75:7, pages 609-623.
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Suzy Scholl, Diana Bello Roufai, Linda Larbi ChérifMaud Kamal. (2023) RAIDS atlas of significant genetic and protein biomarkers in cervical cancer. Journal of Gynecologic Oncology 34:5.
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Meijie Chen, Xuena Li, Bulin Du, Song Chen & Yaming Li. (2022) Upstream stimulatory factor 2 inhibits erastin-induced ferroptosis in pancreatic cancer through transcriptional regulation of pyruvate kinase M2. Biochemical Pharmacology 205, pages 115255.
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Junying Zhou, Ningjing Lei, Wanjia Tian, Ruixia Guo, Mengyu Chen, Luojie Qiu, Fengling Wu, Yong Li & Lei Chang. (2022) Recent progress of the tumor microenvironmental metabolism in cervical cancer radioresistance. Frontiers in Oncology 12.
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Ling Zhang, Bin Wang, Zhi-Shun Wang, Yong-Lian Guo & Hao Shen. (2022) Construction of Glycolytic Regulator Gene Signature to Predict the Prognosis and Tumor Immune Cell Infiltration Levels for Prostate Cancer. Computational and Mathematical Methods in Medicine 2022, pages 1-13.
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Sahil Arora, Gaurav Joshi, Anuhar Chaturvedi, Michael Heuser, Santoshkumar Patil & Raj Kumar. (2021) A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2. Journal of Medicinal Chemistry 65:2, pages 1171-1205.
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Bi Wang, Yingnan Yuan, Yin Zou, Zhengjun Qi, Guijia Huang, Yi Liu, Shan Xia, Yu Huang & Zhi Huang. (2021) Fructose-1,6-bisphosphatase 2 represses cervical cancer progression via inhibiting aerobic glycolysis through promoting pyruvate kinase isozyme type M2 ubiquitination. Anti-Cancer Drugs 33:1, pages e198-e206.
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Zhi Yu, Dan Wang & Yingying Tang. (2021) PKM2 promotes cell metastasis and inhibits autophagy via the JAK/STAT3 pathway in hepatocellular carcinoma. Molecular and Cellular Biochemistry 476:5, pages 2001-2010.
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Hailun Zheng, Mei Zhang, Xiquan Ke, Xiaojing Deng, Dapeng Li, Qizhi Wang, Shanjun Yan, Yongju Xue & Qiangwu Wang. (2021) LncRNA XIST/miR-137 axis strengthens chemo-resistance and glycolysis of colorectal cancer cells by hindering transformation from PKM2 to PKM1. Cancer Biomarkers 30:4, pages 395-406.
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Xun Chen, Shangwu Chen & Dongsheng Yu. (2020) Protein kinase function of pyruvate kinase M2 and cancer. Cancer Cell International 20:1.
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Quan Wan, Wangxiang Yan, Yonghong Liu, Yanzhu Lin & Zhiyuan Lu. (2020) Prognostic value of post-radiation serum squamous cell carcinoma antigen and primary tumor regression for cervical squamous cell carcinoma. Cancer Biomarkers 29:3, pages 327-335.
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Zhi Zhou Li, Fei Wang, Shuang Liu, Hui Li & Yang Wang. (2020) Ablation of PKM2 ameliorated ER stress‐induced apoptosis and associated inflammation response in IL‐1β‐treated chondrocytes via blocking Rspo2‐mediated Wnt/β‐catenin signaling. Journal of Cellular Biochemistry 121:10, pages 4204-4213.
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Wenjing Guo, Zhishuai Zhang, Guihuan Li, Xiaoju Lai, Ruonan Gu, Wanfu Xu, Hua Chen, Zhe Xing, Liping Chen, Jiabi Qian, Shiyuan Xu, Fangyin Zeng & Fan Deng. (2020) Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling. Frontiers in Oncology 10.
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Bing‐Xia Zhou & Yan Li. (2020) Significance of desmoglein‐2 on cell malignant behaviors via mediating MAPK signaling in cervical cancer. The Kaohsiung Journal of Medical Sciences 36:5, pages 336-343.
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Shuizhong Cen, Jinteng Li, Zhaopeng Cai, Yiqian Pan, Zehang Sun, Zhaofeng Li, Guiwen Ye, Guan Zheng, Ming Li, Wenjie Liu, Wenhui Yu, Shan Wang, Zhongyu Xie, Peng Wang & Huiyong Shen. (2020) TRAF4 acts as a fate checkpoint to regulate the adipogenic differentiation of MSCs by activating PKM2. EBioMedicine 54, pages 102722.
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Yanzhu Lin, Hui Zhai, Yi Ouyang, Zhiyuan Lu, Chengbiao Chu, Qianting He & Xinping Cao. (2019) Knockdown of PKM2 enhances radiosensitivity of cervical cancer cells. Cancer Cell International 19:1.
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Yi Liu, Qingluan Liu, Shumin Chen, Yijun Liu, Yumei Huang, Pan Chen, Xiayu Li, Ge Gao, Keqian Xu, Songqing Fan, Zhaoyang Zeng, Wei Xiong, Ming Tan, Guiyuan Li & Wenling Zhang. (2019) APLNR is involved in ATRA‐induced growth inhibition of nasopharyngeal carcinoma and may suppress EMT through PI3K‐Akt‐mTOR signaling. The FASEB Journal 33:11, pages 11959-11972.
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Shuo Yang, Yueli Gu, Genjie Wang, Qingzhu Hu, Shuxia Chen, Yong Wang & Mingfeng Zhao. (2019) HMGA2 regulates acute myeloid leukemia progression and sensitivity to daunorubicin via Wnt/β-catenin signaling. International Journal of Molecular Medicine.
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Zhenqi Liu & Baichun Yang. (2019) Drug Development Strategy for Type 2 Diabetes: Targeting Positive Energy Balances. Current Drug Targets 20:8, pages 879-890.
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Knockdown of PKM2 suppresses tumor progression in human cervical cancer by modulating epithelial–mesenchymal transition via Wnt/β-catenin signaling

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Knockdown of PKM2 suppresses tumor progression in human cervical cancer by modulating epithelial–mesenchymal transition via Wnt/β-catenin signaling

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