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Cancer Management and Research Volume 10, 2018 - Issue
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Original Research

HJC0152, a novel STAT3 inhibitor with promising anti-tumor effect in gastric cancer

Xiaoxia Jiang1 Department of Surgical Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China, [email protected];2 Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, People’s Republic of China, [email protected]
,
Mengjie Wu1 Department of Surgical Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China, [email protected];2 Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, People’s Republic of China, [email protected]
,
Zhenzhen Xu1 Department of Surgical Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China, [email protected];2 Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, People’s Republic of China, [email protected]
,
Haohao Wang1 Department of Surgical Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China, [email protected];2 Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, People’s Republic of China, [email protected]
,
Haiyong Wang1 Department of Surgical Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China, [email protected];2 Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, People’s Republic of China, [email protected]
,
Xiongfei Yu1 Department of Surgical Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China, [email protected]
,
Zhongqi Li1 Department of Surgical Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China, [email protected]
&
Lisong Teng1 Department of Surgical Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China, [email protected];2 Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, People’s Republic of China, [email protected]Correspondence[email protected]
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Pages 6857-6867 | Published online: 12 Dec 2018

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Feng Wang, Xin-Yu Cao, Guo-Qiang Lin, Ping Tian & Dingding Gao. (2022) Novel inhibitors of the STAT3 signaling pathway: an updated patent review (2014-present). Expert Opinion on Therapeutic Patents 32:6, pages 667-688.
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Furong Wang, Sigong Zhang, Yucai Wei, Hao Chen, Zuoyi Jiao & Yumin Li. (2019) Upregulation of family with sequence similarity 83 member D expression enhances cell proliferation and motility via activation of Wnt/β-catenin signaling and predicts poor prognosis in gastric cancer. Cancer Management and Research 11, pages 6775-6791.
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Articles from other publishers (14)

Yamei Hu, Zigang Dong & Kangdong Liu. (2024) Unraveling the complexity of STAT3 in cancer: molecular understanding and drug discovery. Journal of Experimental & Clinical Cancer Research 43:1.
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Omer Goldman, Lital N. Adler, Emma Hajaj, Tommaso Croese, Naama Darzi, Sivan Galai, Hila Tishler, Yarden Ariav, Dor Lavie, Liat Fellus-Alyagor, Roni Oren, Yuri Kuznetsov, Eyal David, Rami Jaschek, Chani Stossel, Oded Singer, Sergey Malitsky, Renana Barak, Rony Seger, Neta Erez, Ido Amit, Amos Tanay, Ann Saada, Talia Golan, Tamar Rubinek, Joo Sang Lee, Shay Ben-Shachar, Ido Wolf & Ayelet Erez. (2023) Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis. Cancer Discovery 13:7, pages 1616-1635.
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Hitesh Vasiyani, Bhumika Wadhwa & Rajesh Singh. (2023) Regulation of cGAS-STING signalling in cancer: Approach for combination therapy. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1878:3, pages 188896.
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Hitesh Vasiyani, Minal Mane, Khushboo Rana, Anjali Shinde, Milton Roy, Jyoti Singh, Dhruv Gohel, Fatema Currim, Ratika Srivastava & Rajesh Singh. (2022) DNA damage induces STING mediated IL-6-STAT3 survival pathway in triple-negative breast cancer cells and decreased survival of breast cancer patients. Apoptosis 27:11-12, pages 961-978.
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Lin Deng, Jianshan Mo, Yi Zhang, Keren Peng, Huaxuan Li, Shumin Ouyang, Zongbo Feng, Wei Fang, Jianwei Wei, Deqin Rong, Xiaolei Zhang & Yuanxiang Wang. (2022) Boronic Acid: A Novel Pharmacophore Targeting Src Homology 2 (SH2) Domain of STAT3. Journal of Medicinal Chemistry 65:19, pages 13094-13111.
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Peace Wun-Ang Lu, Chia-Hsuan Chou, Jia-Sin Yang, Yi-Hsien Hsieh, Meng-Ying Tsai, Ko-Hsiu Lu & Shun-Fa Yang. (2022) HO-3867 Induces Apoptosis via the JNK Signaling Pathway in Human Osteosarcoma Cells. Pharmaceutics 14:6, pages 1257.
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Jimin Xu, Hyejin Kim, Jiabin Dong, Haiying Chen, Junhai Xu, Ruixia Ma, Mingxiang Zhou, Tianzhi Wang, Qiang Shen & Jia Zhou. (2022) Structure-activity relationship studies on O-alkylamino-tethered salicylamide derivatives with various amino acid linkers as potent anticancer agents. European Journal of Medicinal Chemistry 234, pages 114229.
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Malik Bisserier, Michael G. Katz, Carlos Bueno-Beti, Agnieszka Brojakowska, Shihong Zhang, Sarah Gubara, Erik Kohlbrenner, Shahood Fazal, Anthony Fargnoli, Peter Dorfmuller, Marc Humbert, Akiko Hata, David A. Goukassian, Yassine Sassi & Lahouaria Hadri. (2021) Combination Therapy with STAT3 Inhibitor Enhances SERCA2a-Induced BMPR2 Expression and Inhibits Pulmonary Arterial Hypertension. International Journal of Molecular Sciences 22:17, pages 9105.
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Christian Sommerhalder, Claire B. Cummins, Xiaofu Wang, Divya Ramdas, Omar Nunez Lopez, Yanping Gu, Jia Zhou & Ravi S. Radhakrishnan. (2021) HJC0416 Attenuates Fibrogenesis in Activated Hepatic Stellate Cells via STAT3 and NF-κB Pathways. Journal of Surgical Research 261, pages 334-342.
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Milad Ashrafizadeh, Ali Zarrabi, Sima Orouei, Vahideh Zarrin, Ebrahim Rahmani Moghadam, Amirhossein Zabolian, Shima Mohammadi, Kiavash Hushmandi, Yashar Gharehaghajlou, Pooyan Makvandi, Masoud Najafi & Reza Mohammadinejad. (2020) STAT3 Pathway in Gastric Cancer: Signaling, Therapeutic Targeting and Future Prospects. Biology 9:6, pages 126.
Crossref
Binnari Kim, Jiryeon Jang, You Jeong Heo, So Young Kang, Heejin Yoo, Insuk Sohn, Byung-Hoon Min & Kyoung-Mee Kim. (2020) Dysregulated miRNA in a cancer-prone environment: A study of gastric non-neoplastic mucosa. Scientific Reports 10:1.
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Lu Lu, Hang Li, Xin Wu, Jun Rao, Jia Zhou, Saijun Fan & Qiang Shen. (2020) HJC0152 suppresses human non–small‐cell lung cancer by inhibiting STAT3 and modulating metabolism. Cell Proliferation 53:3.
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Qiuyao Huang, Yan Zhong, Hui Dong, Qiyao Zheng, Shuo Shi, Kai Zhu, Xinming Qu, Wenhao Hu, Xiaolei Zhang & Yuanxiang Wang. (2020) Revisiting signal transducer and activator of transcription 3 (STAT3) as an anticancer target and its inhibitor discovery: Where are we and where should we go?. European Journal of Medicinal Chemistry 187, pages 111922.
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Sojin Lee, Cuiling Zhu, Jun Yamauchi, Ping Zhu, Xiaoyun Feng, Shen Qu & H. Henry Dong. 2020. Lipid Signaling and Metabolism. Lipid Signaling and Metabolism 247 272 .

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