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Original Research

BCL11A enhances stemness and promotes progression by activating Wnt/β-catenin signaling in breast cancer

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Pages 2997-3007 | Published online: 11 Apr 2019

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Junhong Cai, Siyuan Peng, Haibo Wang & Shan Bao. (2022) The Impact of BCL11A Polymorphisms on Endometrial Cancer Risk Among Chinese Han Females. Pharmacogenomics and Personalized Medicine 15, pages 311-325.
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Dezaree Raut, Amisha Vora & Lokesh Kumar Bhatt. (2022) The Wnt/β-catenin pathway in breast cancer therapy: a pre-clinical perspective of its targeting for clinical translation. Expert Review of Anticancer Therapy 22:1, pages 97-114.
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PengYu Yang, Wei Kang, YaWen Pan, XianJun Zhao & Lei Duan. (2019) Overexpression of HOXC6 promotes cell proliferation and migration via MAPK signaling and predicts a poor prognosis in glioblastoma. Cancer Management and Research 11, pages 8167-8179.
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Articles from other publishers (27)

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A. S Ponomarev, Z. E Gilazieva, V. V Solovyova & A. A Rizvanov. (2023) Molecular mechanisms of tumor cell stemness modulation during formation of spheroids: a review. Биохимия 88:7, pages 1204-1222.
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Alejandro Ordaz-Ramos, Olivia Tellez-Jimenez & Karla Vazquez-Santillan. (2023) Signaling pathways governing the maintenance of breast cancer stem cells and their therapeutic implications. Frontiers in Cell and Developmental Biology 11.
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Aleksei S. Ponomarev, Zarema E. Gilazieva, Valeriya V. Solovyova & Albert A. Rizvanov. (2023) Molecular Mechanisms of Tumor Cell Stemness Modulation during Formation of Spheroids. Biochemistry (Moscow) 88:7, pages 979-994.
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Andrea Angius, Giovanna Pira, Paolo Cossu-Rocca, Giovanni Sotgiu, Laura Saderi, Maria Rosaria Muroni, Patrizia Virdis, Daniela Piras, Rallo Vincenzo, Ciriaco Carru, Donatella Coradduzza, Maria Gabriela Uras, Pierina Cottu, Alessandro Fancellu, Sandra Orrù, Paolo Uva & Maria Rosaria De Miglio. (2022) Deciphering clinical significance of BCL11A isoforms and protein expression roles in triple-negative breast cancer subtype. Journal of Cancer Research and Clinical Oncology 149:7, pages 3951-3963.
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Jiawei Yin, Xiaoli Xie, Yanchun Quan, Zhiqiang Wang, Shu Liu, Quanping Su, Fengyuan Che & Lijuan Wang. (2023) RNA-seq analysis reveals candidate genes associated with proliferation, invasion, and migration in BCL11A knockdown B-NHL cell lines. Annals of Hematology 102:7, pages 1845-1856.
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Ewa Kątnik, Agnieszka Gomułkiewicz, Aleksandra Piotrowska, Jędrzej Grzegrzółka, Alicja Kmiecik, Katarzyna Ratajczak-Wielgomas, Anna Urbaniak, Natalia Glatzel-Plucińska, Piotr Błasiak & Piotr Dzięgiel. (2023) BCL11A Expression in Non-Small Cell Lung Cancers. International Journal of Molecular Sciences 24:12, pages 9848.
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Ewa Kątnik, Agnieszka Gomułkiewicz, Aleksandra Piotrowska, Jędrzej Grzegrzółka, Agnieszka Rusak, Alicja Kmiecik, Katarzyna Ratajczak-Wielgomas & Piotr Dzięgiel. (2023) BCL11A Expression in Breast Cancer. Current Issues in Molecular Biology 45:4, pages 2681-2698.
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Miray Unlu Yazici, J. S. Marron, Burcu Bakir-Gungor, Fei Zou & Malik Yousef. (2023) Invention of 3Mint for feature grouping and scoring in multi-omics. Frontiers in Genetics 14.
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Mehrdad Hashemi, Sahar Hasani, Shima Hajimazdarany, Fatemeh Ghadyani, Yeganeh Olyaee, Marzieh Khodadadi, Maryam Fallah Ziyarani, Amir Dehghanpour, Hasti Salehi, Amirabbas Kakavand, Mohammad Ali Sheikh Beig Goharrizi, Amir Reza Aref, Shokooh Salimimoghadam, Mohammad Esmaeil Akbari, Afshin Taheriazam, Kiavash Hushmandi & Maliheh Entezari. (2023) Biological functions and molecular interactions of Wnt/β-catenin in breast cancer: Revisiting signaling networks. International Journal of Biological Macromolecules 232, pages 123377.
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Qianya Jin, Yanmin Chen, Shibei Du, Dongqing Xu, Juanqing Yue, Lei Cai & Xiaojun Yuan. (2022) BCL11A Facilitates Cell Proliferation and Metastasis in Neuroblastoma via Regulating the PI3K/Akt Signaling Pathway. Current Cancer Drug Targets 22:11, pages 919-930.
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Zhenlu Li, Xing Huang, Weiming Hu & Huimin Lu. (2022) Down-regulation of USP22 reduces cell stemness and enhances the sensitivity of pancreatic cancer cells to cisplatin by inactivating the Wnt/β-catenin pathway. Tissue and Cell 77, pages 101787.
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Md. Shahin Alam, Adiba Sultana, Md. Selim Reza, Md Amanullah, Syed Rashel Kabir & Md. Nurul Haque Mollah. (2022) Integrated bioinformatics and statistical approaches to explore molecular biomarkers for breast cancer diagnosis, prognosis and therapies. PLOS ONE 17:5, pages e0268967.
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Willy Antoni Abreu de Oliveira, Youssef El Laithy, Alejandra Bruna, Daniela Annibali & Frederic Lluis. (2022) Wnt Signaling in the Breast: From Development to Disease. Frontiers in Cell and Developmental Biology 10.
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Xianbin Zhang, Li Li, Peng Liu, Yu Tian & Peng Gong. (2022) Development of a Transcription Factor-Based Prognostic Model for Predicting the Immune Status and Outcome in Pancreatic Adenocarcinoma. Journal of Immunology Research 2022, pages 1-16.
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Jodi M. Saunus, Xavier M. De Luca, Korinne Northwood, Ashwini Raghavendra, Alexander Hasson, Amy E. McCart Reed, Malcolm Lim, Samir Lal, A. Cristina Vargas, Jamie R. Kutasovic, Andrew J. Dalley, Mariska Miranda, Emarene Kalaw, Priyakshi Kalita-de Croft, Irma Gresshoff, Fares Al-Ejeh, Julia M. W. Gee, Chris Ormandy, Kum Kum Khanna, Jonathan Beesley, Georgia Chenevix-Trench, Andrew R. Green, Emad A. Rakha, Ian O. Ellis, Dan V. NicolauJrJr, Peter T. Simpson & Sunil R. Lakhani. (2022) Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer. npj Breast Cancer 8:1.
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Alexey Ponomarev, Zarema Gilazieva, Valeriya Solovyeva, Cinzia Allegrucci & Albert Rizvanov. (2022) Intrinsic and Extrinsic Factors Impacting Cancer Stemness and Tumor Progression. Cancers 14:4, pages 970.
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Samreen Fathima, Swati Sinha & Sainitin Donakonda. (2022) Unraveling unique and common cell type-specific mechanisms in glioblastoma multiforme. Computational and Structural Biotechnology Journal 20, pages 90-106.
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Ching-Te Kuo & Hsinyu Lee. 2022. Handbook of Single-Cell Technologies. Handbook of Single-Cell Technologies 851 863 .
Cenzhu Wang, Kun Xu, Runtian Wang, Xin Han, Jinhai Tang & Xiaoxiang Guan. (2021) Heterogeneity of BCSCs contributes to the metastatic organotropism of breast cancer. Journal of Experimental & Clinical Cancer Research 40:1.
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Juntao Li, Dan Qi, Tze-Chen Hsieh, Jason H. Huang, Joseph M. Wu & Erxi Wu. (2021) Trailblazing perspectives on targeting breast cancer stem cells. Pharmacology & Therapeutics 223, pages 107800.
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Darcie D. Seachrist, Molly M. Hannigan, Natasha N. Ingles, Bryan M. Webb, Kristen L. Weber-Bonk, Peng Yu, Gurkan Bebek, Salendra Singh, Steven T. Sizemore, Vinay Varadan, Donny D. Licatalosi & Ruth A. Keri. (2020) The transcriptional repressor BCL11A promotes breast cancer metastasis. Journal of Biological Chemistry 295:33, pages 11707-11719.
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Li Sun, Changlong Shi, Shaozhuang Liu, Enchong Zhang, Long Yan, Ce Ji & Yi Zhao. (2020) Overexpression of NuSAP1 is predictive of an unfavourable prognosis and promotes proliferation and invasion of triple-negative breast cancer cells via the Wnt/β-catenin/EMT signalling axis. Gene 747, pages 144657.
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Hongyun Shi, Chun Li, Wei Feng, Jianjun Yue, Jingfang Song, Aizhi Peng & Hua Wang. (2020) BCL11A Is Oncogenic and Predicts Poor Outcomes in Natural Killer/T-Cell Lymphoma. Frontiers in Pharmacology 11.
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Iyad Sultan & Abdelghani Tbakhi. (2020) BCL11A gene over-expression in high risk neuroblastoma. Cancer Genetics 244, pages 30-31.
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Oleg I. Kit, Vladimir S. Trifanov, Nataliya A. Petrusenko, Dmitry Y. Gvaldin, Denis S. Kutilin & Nataliya N. Timoshkina. (2020) Identification of new candidate genes and signalling pathways associated with the development of neuroendocrine pancreatic tumours based on next generation sequencing data. Molecular Biology Reports 47:6, pages 4233-4243.
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Ching-Te Kuo & Hsinyu Lee. 2020. Handbook of Single Cell Technologies. Handbook of Single Cell Technologies 1 13 .