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Cancer Management and Research Volume 11, 2019 - Issue
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Original Research

Docetaxel, oxaliplatin, leucovorin, and 5-fluorouracil (FLOT) as preoperative and postoperative chemotherapy compared with surgery followed by chemotherapy for patients with locally advanced gastric cancer: a propensity score-based analysis

Keshen Wang1 Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu730010, People’s Republic of China
,
Yanxian Ren1 Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu730010, People’s Republic of China
,
Zhijian Ma2 Cui-ying Experimental Center, Lanzhou University Second Hospital, Lanzhou, Gansu730010, People’s Republic of China
,
Fan Li1 Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu730010, People’s Republic of China
,
Xiaocheng Cheng1 Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu730010, People’s Republic of China
,
Jingying Xiao1 Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu730010, People’s Republic of China
,
Shuze Zhang1 Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu730010, People’s Republic of China
,
Zeyuan Yu1 Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu730010, People’s Republic of China
,
Hanteng Yang1 Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu730010, People’s Republic of China
,
Huinian Zhou1 Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu730010, People’s Republic of China;2 Cui-ying Experimental Center, Lanzhou University Second Hospital, Lanzhou, Gansu730010, People’s Republic of China
,
Yuming Li1 Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu730010, People’s Republic of China;2 Cui-ying Experimental Center, Lanzhou University Second Hospital, Lanzhou, Gansu730010, People’s Republic of China
,
Hongbin Liu3 Department of General Surgery, The 940th Hospital of Joint Logistics Support Force of People’s Liberation Army, Lanzhou730050, People’s Republic of China
&
Zuo-Yi Jiao1 Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu730010, People’s Republic of China;2 Cui-ying Experimental Center, Lanzhou University Second Hospital, Lanzhou, Gansu730010, People’s Republic of ChinaCorrespondence[email protected]
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Pages 3009-3020 | Published online: 10 Apr 2019

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Yonglei Zhang, Bin Zhang, Jinpo Yang, Jindai Zhang & Wei Zhang. (2021) Perioperative Safety and Effectiveness of Neoadjuvant Therapy with Fluorouracil, Leucovorin, Oxaliplatin, and Docetaxel Plus Apatinib in Locally Advanced Gastric Cancer. Cancer Management and Research 13, pages 2279-2286.
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Articles from other publishers (21)

Abeer M.A. Attia, Khaled H. Gad, Amr M.M. El Hefny & Mohammed A.A. Hamed. (2024) Meta-analysis of laparoscopic versus open D2 gastrectomy in managing locally advanced gastric cancer: early postoperative course and pathological outcomes. The Egyptian Journal of Surgery 43:1, pages 230-244.
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Yuan Tian, Peigang Yang, Honghai Guo, Yang Liu, Ze Zhang, Pingan Ding, Tao Zheng, Huiyan Deng, Wenqian Ma, Yong Li, Liqiao Fan, Zhidong Zhang, Dong Wang, Xuefeng Zhao, Bibo Tan, Yu Liu & Qun Zhao. (2023) Neoadjuvant docetaxel, oxaliplatin plus capecitabine versus oxaliplatin plus capecitabine for patients with locally advanced gastric adenocarcinoma: long-term results of a phase III randomized controlled trial. International Journal of Surgery 109:12, pages 4000-4008.
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Huili Ye, Wengui Shi, Jing Yang, Long Wang, Xiangyan Jiang, Huiming Zhao, Long Qin, Junjie Qin, Lianshun Li, Weiwen Cai, Junhong Guan, Hanteng Yang, Huinian Zhou, Zeyuan Yu, Hui Sun & Zuoyi Jiao. (2023) PICH Activates Cyclin A1 Transcription to Drive S-Phase Progression and Chemoresistance in Gastric Cancer. Cancer Research 83:22, pages 3767-3782.
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Meng Zhang, Heli Yang, Tao Fu, Meizhu Meng, Yi Feng, Changda Qu, Zhongwu Li, Xiaofang Xing, Wenmei Li, Meiying Ye, Sisi Li, Zhaode Bu & Shuqin Jia. (2023) Liquid biopsy: circulating tumor DNA monitors neoadjuvant chemotherapy response and prognosis in stage II / III gastric cancer . Molecular Oncology 17:9, pages 1930-1942.
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Stylianos Fiflis, Menelaos Papakonstantinou, Alexandros Giakoustidis, Gregory Christodoulidis, Eleni Louri, Vasileios N Papadopoulos & Dimitrios Giakoustidis. (2023) Comparison between upfront surgery and neoadjuvant chemotherapy in patients with locally advanced gastric cancer: A systematic review. World Journal of Gastrointestinal Surgery 15:8, pages 1808-1818.
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K. A. Oganyan, A. A. Musaelyan, S. V. Lapin, T. V. Kupenskaya, A. A. Sveсhkova, M. A. Belyaev, A. A. Zakharenko & S. V. Orlov. (2023) Molecular markers as predictors of response to perioperative chemotherapy in locally advanced gastric cancer. Advances in Molecular Oncology 10:1, pages 40-48.
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Ali Forouhari, Azadeh Moghaddas & Ali Darakhshandeh. (2023) Outcome evaluation of ECF, DCF, FOLFOX, and FLOT chemotherapy regimens as perioperative treatment in elderly patients with resectable gastric cancer; A retrospective comparative study. Journal of Research in Medical Sciences 28:1, pages 79.
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Shirin Kianersi, Sina Salari, Hamid Rezvani, MohammadA Araskhan, Alireza Shirangi, MohammadR Fathi & MahmoudD Ghorbi. (2023) Neoadjuvant chemotherapy outcome with taxane-based versus non-taxane protocols in gastric cancer. Journal of Education and Health Promotion 12:1, pages 205.
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P. López Sala, M. Leturia Etxeberria, E. Inchausti Iguíñiz, A. Astiazaran Rodríguez, M.I. Aguirre Oteiza & M. Zubizarreta Etxaniz. (2023) Gastric adenocarcinoma: A review of the TNM classification system and ways of spreading. Radiología (English Edition) 65:1, pages 66-80.
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P. López Sala, M. Leturia Etxeberria, E. Inchausti Iguíñiz, A. Astiazaran Rodríguez, M.I. Aguirre Oteiza & M. Zubizarreta Etxaniz. (2023) Adenocarcinoma gástrico: revisión del TNM y de las vías de diseminación. Radiología 65:1, pages 66-80.
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Silvia Carbonell Morote, Ester Gracia Alegría, Emilio Ruiz de la Cuesta Tapia, Clara Llopis Torremocha, Sergio Ortiz Sebastián, José Luis Estrada Caballero, Celia Villodre & José Manuel Ramia. (2023) Textbook outcome en cirugía gástrica oncológica, ¿qué implicaciones tiene sobre la supervivencia?. Cirugía Española 101:1, pages 20-28.
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Silvia Carbonell Morote, Ester Gracia Alegría, Emilio Ruiz de la Cuesta Tapia, Clara Llopis Torremocha, Sergio Ortiz Sebastián, José Luis Estrada Caballero, Celia Villodre & José Manuel Ramia. (2023) Textbook outcome in gastric surgery, what implications does it have on survival?. Cirugía Española (English Edition) 101:1, pages 20-28.
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Iago Dillion Lima CavalcantiIago Dillion Lima Cavalcanti. 2022. Chemotherapy Protocols and Infusion Sequence. Chemotherapy Protocols and Infusion Sequence 125 200 .
Mira Runkel, Rasmus Verst, Julia Spiegelberg, Stefan Fichtner-Feigl, Jens Hoeppner & Torben Glatz. (2021) Perioperative FLOT chemotherapy plus surgery for oligometastatic esophagogastric adenocarcinoma: surgical outcome and overall survival. BMC Surgery 21:1.
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Carolina MannMaurice Michel & Peter Grimminger. (2021) Multimodale Therapie des resektablen Ösophaguskarzinoms. TumorDiagnostik & Therapie 42:09, pages 672-680.
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Carolina Mann, Maurice Michel & Peter Grimminger. (2021) Multimodale Therapie des resektablen Ösophaguskarzinoms. Gastroenterologie up2date 17:02, pages 137-149.
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Lu‐yang Zhang, Jun‐jun Ma, Lu Zang, Hi‐ju Hong, Ai‐guo Lu, Zi‐rui He, Tian‐yu Jiang, Xuan Zhao, Abe Fingerhut & Min‐Hua Zheng. (2021) Staged laparoscopic management of locally advanced gastric cancer with outlet obstruction. Journal of Surgical Oncology 123:S1.
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Carolina Mann, Markus Möhler & Peter Grimminger. (2021) Multimodale Therapie des Ösophaguskarzinoms. Allgemein- und Viszeralchirurgie up2date 15:01, pages 79-90.
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Feng Wu, Jiaze Hong, Nannan Du, Yiran Wang, Juan Chen, Yuanfang He & Ping Chen. (2021) Long-Term Outcomes of Neoadjuvant Chemotherapy in Locally Advanced Gastric Cancer/Esophagogastric Junction Cancer: A Systematic Review and Meta-Analysis. Anti-Cancer Agents in Medicinal Chemistry 22:1, pages 143-151.
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Birendra Kumar Sah, Benyan Zhang, Huan Zhang, Jian Li, Fei Yuan, Tao Ma, Min Shi, Wei Xu, Zhenglun Zhu, Wentao Liu, Chao Yan, Chen Li, Bingya Liu, Min Yan & Zhenggang Zhu. (2020) Neoadjuvant FLOT versus SOX phase II randomized clinical trial for patients with locally advanced gastric cancer. Nature Communications 11:1.
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Xiaoyang Xu, Xiaojing Chang, Yan Xu, Peng Deng, Jiang Wang, Chundong Zhang, Xinjiang Zhu, Shuchen Chen & Dongqiu Dai. (2020) SAMD14 promoter methylation is strongly associated with gene expression and poor prognosis in gastric cancer. International Journal of Clinical Oncology 25:6, pages 1105-1114.
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