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Cancer Management and Research Volume 11, 2019 - Issue
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Original Research

The β-galactoside α2,6-sialyltranferase 1 (ST6GAL1) inhibits the colorectal cancer metastasis by stabilizing intercellular adhesion molecule-1 via sialylation

Leqi Zhou1 Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;2 Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Sen Zhang1 Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;2 Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Xia Zou3 Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine (SCSB), Shanghai Jiao Tong University, Shanghai, People’s Republic of China
,
Jishun Lu3 Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine (SCSB), Shanghai Jiao Tong University, Shanghai, People’s Republic of China
,
Xiao Yang1 Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;2 Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Zhijue Xu3 Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine (SCSB), Shanghai Jiao Tong University, Shanghai, People’s Republic of China
,
Aidong Shan3 Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine (SCSB), Shanghai Jiao Tong University, Shanghai, People’s Republic of China
,
Wenjuan Jia3 Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine (SCSB), Shanghai Jiao Tong University, Shanghai, People’s Republic of China
,
Feng Liu3 Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine (SCSB), Shanghai Jiao Tong University, Shanghai, People’s Republic of China
,
Xialin Yan1 Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;2 Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Hao Su1 Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;2 Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Tao Liang3 Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine (SCSB), Shanghai Jiao Tong University, Shanghai, People’s Republic of China
,
Minhua Zheng1 Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;2 Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Yan Zhang3 Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine (SCSB), Shanghai Jiao Tong University, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
&
Bo Feng1 Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;2 Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
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Pages 6185-6199 | Published online: 04 Jul 2019

Citations (15)

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Wenyao Zhang, Zhiping Yang, Xiaoliang Gao & Qiong Wu. (2020) Advances in the Discovery of Novel Biomarkers for Cancer: Spotlight on Protein N-Glycosylation. Biomarkers in Medicine 14:11, pages 1031-1045.
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Articles from other publishers (14)

Rubén López-Cortés, Laura Muinelo-Romay, Almudena Fernández-Briera & Emilio Gil Martín. (2024) High-Throughput Mass Spectrometry Analysis of N -Glycans and Protein Markers after FUT8 Knockdown in the Syngeneic SW480/SW620 Colorectal Cancer Cell Model . Journal of Proteome Research 23:4, pages 1379-1398.
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Na Peng, Jingwei Liu, Shuangshuang Hai, Yihong Liu, Haibo Zhao & Weixin Liu. (2024) Role of Post-Translational Modifications in Colorectal Cancer Metastasis. Cancers 16:3, pages 652.
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Ranim Al Saoud, Amar Hamrouni, Adi Idris, Walaa K. Mousa & Tareq Abu Izneid. (2023) Recent advances in the development of sialyltransferase inhibitors to control cancer metastasis: A comprehensive review. Biomedicine & Pharmacotherapy 165, pages 115091.
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Xia Zou, Jishun Lu, Yao Deng, Qiannan Liu, Xialin Yan, Yalu Cui, Xiao Xiao, Meng Fang, Fang Yang, Hiromichi Sawaki, Takashi Sato, Binbin Tan, Xiaoyan Lu, Bo Feng, Atsushi Kuno, Hisashi Narimatsu, Chunfang Gao & Yan Zhang. (2022) ST6GAL1 inhibits metastasis of hepatocellular carcinoma via modulating sialylation of MCAM on cell surface. Oncogene 42:7, pages 516-529.
Crossref
Zhiyuan Qiu, Yan Wang, Zhao Zhang, Rong Qin, Yong Peng, Weifeng Tang, Yan Xi, Guangyu Tian & Yeqing Zhang. (2022) Roles of intercellular cell adhesion molecule-1 (ICAM-1) in colorectal cancer: expression, functions, prognosis, tumorigenesis, polymorphisms and therapeutic implications. Frontiers in Oncology 12.
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Ru Wen, Hongjuan Zhao, Dalin Zhang, Chun-Lung Chiu & James D. Brooks. (2022) Sialylated glycoproteins as biomarkers and drivers of progression in prostate cancer. Carbohydrate Research 519, pages 108598.
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Sajina GC, Susan L. Bellis & Anita B. Hjelmeland. (2022) ST6Gal1: Oncogenic signaling pathways and targets. Frontiers in Molecular Biosciences 9.
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Hui Zhou, Zhongtao Liu, Yongxiang Wang, Xiaoyong Wen, Eric H. Amador, Liqin Yuan, Xin Ran, Li Xiong, Yuping Ran, Wei Chen & Yu Wen. (2022) Colorectal liver metastasis: molecular mechanism and interventional therapy. Signal Transduction and Targeted Therapy 7:1.
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Kaitlyn A Dorsett, Michael P Marciel, Jihye Hwang, Katherine E Ankenbauer, Nikita Bhalerao & Susan L Bellis. (2021) Regulation of ST6GAL1 sialyltransferase expression in cancer cells. Glycobiology 31:5, pages 530-539.
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Silvia Pietrobono & Barbara Stecca. (2021) Aberrant Sialylation in Cancer: Biomarker and Potential Target for Therapeutic Intervention?. Cancers 13:9, pages 2014.
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Philip Rosenstock & Thomas Kaufmann. (2021) Sialic Acids and Their Influence on Human NK Cell Function. Cells 10:2, pages 263.
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Philip Rosenstock, Kaya Bork, Chiara Massa, Philipp Selke, Barbara Seliger & Rüdiger Horstkorte. (2020) Sialylation of Human Natural Killer (NK) Cells Is Regulated by IL-2. Journal of Clinical Medicine 9:6, pages 1816.
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Thomas J. Bauer, Erich Gombocz, Markus Wehland, Johann Bauer, Manfred Infanger & Daniela Grimm. (2020) Insight in Adhesion Protein Sialylation and Microgravity Dependent Cell Adhesion—An Omics Network Approach. International Journal of Molecular Sciences 21:5, pages 1749.
Crossref
Cheorl-Ho KimCheorl-Ho Kim. 2020. Ganglioside Biochemistry. Ganglioside Biochemistry 35 53 .

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