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Cancer Management and Research Volume 11, 2019 - Issue
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Original Research

Emodin sensitizes human pancreatic cancer cells to EGFR inhibitor through suppressing Stat3 signaling pathway

Zhaohong Wang1 Department of Hepatobiliary Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou325000, People’s Republic of China;2 Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou325000, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-9958-4944
ORCID Icon,
Hui Chen1 Department of Hepatobiliary Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou325000, People’s Republic of China
,
Jingjing Chen1 Department of Hepatobiliary Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou325000, People’s Republic of China
,
Zhong Hong1 Department of Hepatobiliary Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou325000, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-5825-0569
ORCID Icon,
Yi Liao1 Department of Hepatobiliary Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou325000, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-7307-0830
ORCID Icon,
Qiyu Zhang1 Department of Hepatobiliary Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou325000, People’s Republic of China;2 Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou325000, People’s Republic of ChinaCorrespondence[email protected];[email protected] 
&
Hongfei Tong1 Department of Hepatobiliary Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou325000, People’s Republic of China
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Pages 8463-8473 | Published online: 17 Sep 2019

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Shuai Ren, Lina Song, Ying Tian, Li Zhu, Kai Guo, Huifeng Zhang & Zhongqiu Wang. (2021) Emodin-Conjugated PEGylation of Fe3O4 Nanoparticles for FI/MRI Dual-Modal Imaging and Therapy in Pancreatic Cancer. International Journal of Nanomedicine 16, pages 7463-7478.
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Articles from other publishers (22)

Jinhui Wang, Junbo Zou, Yajun Shi, Nan Zeng, Dongyan Guo, He Wang, Chongbo Zhao, Fei Luan, Xiaofei Zhang & Jing Sun. (2024) Traditional Chinese medicine and mitophagy: A novel approach for cardiovascular disease management. Phytomedicine 128, pages 155472.
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Tomoya NishiiKoji OsukaYusuke NishimuraYusuke OhmichiMika OhmichiChiharu SuzukiYoshitaka NagashimaTakahiro OyamaTakashi AbeHiroyuki KatoRyuta Saito. (2024) Protective Mechanism of Stem Cells from Human Exfoliated Deciduous Teeth in Treating Spinal Cord Injury. Journal of Neurotrauma.
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Surya Kant Tripathi, Stuti Biswal, Munmun Panda & Bijesh Kumar Biswal. 2023. Alternative Remedies and Natural Products for Cancer Therapy: An Integrative Approach. Alternative Remedies and Natural Products for Cancer Therapy: An Integrative Approach 210 248 .
Yin-Yue Xu, Min Zhu, Jiang Wu, Long-Biao Luo, Si-jing Dong, Meng-Gai Zhang, Xue Liu, Ke Wang, Hua Luo, Wang-Hui Jing, Lin Wang & Si-Cen Wang. (2023) A mannitol-modified emodin nano-drug restores the intestinal barrier function and alleviates inflammation in a mouse model of DSS-induced ulcerative colitis. Chinese Medicine 18:1.
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Yue Hu, Lin Yang & Yu Lai. (2023) Recent findings regarding the synergistic effects of emodin and its analogs with other bioactive compounds: Insights into new mechanisms. Biomedicine & Pharmacotherapy 162, pages 114585.
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Wu Liu, Eskandar Qaed, Yuelin Zhu, Wenzhang Tian, Yizhen Wang, Le Kang, Xiaodong Ma & Zeyao Tang. (2023) Research Progress and New Perspectives of Anticancer Effects of Emodin. The American Journal of Chinese Medicine 51:07, pages 1751-1793.
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Wamidh H. Talib, Dima Awajan, Reem Ali Hamed, Aya O. Azzam, Asma Ismail Mahmod & Intisar Hadi AL-Yasari. (2022) Combination Anticancer Therapies Using Selected Phytochemicals. Molecules 27:17, pages 5452.
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Wojciech Trybus, Ewa Trybus & Teodora Król. (2022) Emodin Sensitizes Cervical Cancer Cells to Vinblastine by Inducing Apoptosis and Mitotic Death. International Journal of Molecular Sciences 23:15, pages 8510.
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Martyna Nowak-Perlak, Mariusz A. Bromke, Piotr Ziółkowski & Marta Woźniak. (2022) The Comparison of the Efficiency of Emodin and Aloe-Emodin in Photodynamic Therapy. International Journal of Molecular Sciences 23:11, pages 6276.
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Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Habbanakuppe D. Preetham, S. Chandra Nayaka, Vijai K. Gupta, Salundi Basappa, Gautam Sethi & Kanchugarakoppal S. Rangappa. (2022) Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature. Seminars in Cancer Biology 80, pages 157-182.
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Loganayaki Periyasamy, Bharathi Muruganantham, Woo-Yoon Park & Sridhar Muthusami. (2022) Phyto-targeting the CEMIP Expression as a Strategy to Prevent Pancreatic Cancer Metastasis. Current Pharmaceutical Design 28:11, pages 922-946.
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Mohan Shankar G.Mundanattu Swetha, C K Keerthana, Tennyson P Rayginia & Ruby John Anto. (2022) Cancer Chemoprevention: A Strategic Approach Using Phytochemicals. Frontiers in Pharmacology 12.
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Sierra J. McDonald, Brandon N. VanderVeen, Kandy T. Velazquez, Reilly T. Enos, Ciaran M. Fairman, Thomas D. Cardaci, Daping Fan & E. Angela Murphy. (2022) Therapeutic Potential of Emodin for Gastrointestinal Cancers. Integrative Cancer Therapies 21, pages 153473542110674.
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Qi Zheng, Shuo Li, Xiaojiaoyang Li & Runping Liu. (2021) Advances in the study of emodin: an update on pharmacological properties and mechanistic basis. Chinese Medicine 16:1.
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Monika Stompor-Gorący. (2021) The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update. International Journal of Molecular Sciences 22:17, pages 9522.
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Hardeep Singh Tuli, Vaishali Aggarwal, Muobarak Tuorkey, Diwakar Aggarwal, Nidarshana Chaturvedi Parashar, Mehmet Varol, Raj Savla, Ginpreet Kaur, Sonam Mittal & Katrin Sak. (2021) Emodin: A metabolite that exhibits anti-neoplastic activities by modulating multiple oncogenic targets. Toxicology in Vitro 73, pages 105142.
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Bo Li, Xin Zhao, Lei Zhang & Wen Cheng. (2021) RETRACTED: Emodin Interferes With AKT1-Mediated DNA Damage and Decreases Resistance of Breast Cancer Cells to Doxorubicin. Frontiers in Oncology 10.
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Hui Yin, Yan‐Ge Liu, Fei Li, Lun‐Qing Wang, Jian‐Hua Zha, Ying‐Chen Xia, Ben‐Tong Yu & Di‐Hao Wen. (2020) RETRACTED: Resibufogenin suppresses growth and metastasis through inducing caspase‐1‐dependent pyroptosis via ROS‐mediated NF‐κB suppression in non‐small cell lung cancer . The Anatomical Record 304:2, pages 302-312.
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Adam Hermawan, Herwandhani Putri & Rohmad Yudi Utomo. (2020) Functional network analysis reveals potential repurposing of β-blocker atenolol for pancreatic cancer therapy. DARU Journal of Pharmaceutical Sciences 28:2, pages 685-699.
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Delu Gan, Shujun Yue, Yulin Jiang, Dian Zhang, He Shi, Husun Qian, Ting Zhou, Wenli Fang, Mengli Yao, Guowei Zuo & Tingmei Chen. (2020) Nucleus-located PDK1 regulates growth, invasion and migration of breast cancer cells. Life Sciences 253, pages 117722.
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