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Original Research

microR-4449 Promotes Colorectal Cancer Cell Proliferation via Regulation of SOCS3 and Activation of STAT3 Signaling

Zhenkun Yan1 Department of Endoscopy Center, The Third Hospital of Jilin University, Changchun, Jilin, 130022, People’s Republic of ChinaCorrespondence[email protected]

Sen Hong2 Department of Colorectal and Anal Surgery, The First Hospital of Jilin University, Changchun, Jilin, 130022, People’s Republic of ChinaCorrespondence[email protected]

Yumei Song3 Department of Thoracic Oncology, Tumor Hospital of Jilin Province, Changchun, Jilin, 130022, People’s Republic of China

Miaomiao Bi4 Department of Ophthalmology, The Third Hospital of Jilin University, Changchun, Jilin, 130022, People’s Republic of China

Pages 3029-3039 | Published online: 07 Apr 2021

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Yamei Hu, Zigang Dong & Kangdong Liu. (2024) Unraveling the complexity of STAT3 in cancer: molecular understanding and drug discovery. Journal of Experimental & Clinical Cancer Research 43:1.
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Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen & Liyu Xu. (2024) Macrophages-derived exo-miR-4449 induced by Cryptococcus affects HUVEC permeability and promotes pyroptosis in BEAS-2B via the HIC1 pathway. Cytokine 173, pages 156441.
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Jacob G. Ellen, Etai Jacob, Nikos Nikolaou & Natasha Markuzon. (2023) Autoencoder-based multimodal prediction of non-small cell lung cancer survival. Scientific Reports 13:1.
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Feng Liu, Yutingzi Wang, Yang Cao, Zhiwei Wu, De Ma, Jun Cai, Jie Sha & Qing Chen. (2023) Transcription factor B-MYB activates lncRNA CCAT1 and upregulates SOCS3 to promote chemoresistance in colorectal cancer. Chemico-Biological Interactions 374, pages 110412.
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Sura Al-Asadi, Hiba Mansour, Ahmed Jwaid Ataimish, Rusul Al-Kahachi & Jamila Rampurawala. (2023) MicroRNAs Regulate Tumorigenesis by Downregulating SOCS3 Expression: An In silico Approach . Bioinformatics and Biology Insights 17.
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Shuai Yang, Bing Wang, Chang Liu, Qizun Wang, Ronghuan Wang, Weiliang Su, Youfu Zhu, Maohua Li, Zhaoyang Guo, Xiaolin Wu & Feng Chen. (2021) THAP9-AS1 Promotes Tumorigenesis and Reduces ROS Generation through the JAK2/STAT3 Signaling Pathway by Increasing SOCS3 Promoter Methylation in Osteosarcoma. Oxidative Medicine and Cellular Longevity 2021, pages 1-17.
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microR-4449 Promotes Colorectal Cancer Cell Proliferation via Regulation of SOCS3 and Activation of STAT3 Signaling

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microR-4449 Promotes Colorectal Cancer Cell Proliferation via Regulation of SOCS3 and Activation of STAT3 Signaling

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