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Cancer Management and Research Volume 13, 2021 - Issue
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Original Research

SDC2 and TFPI2 Methylation in Stool Samples as an Integrated Biomarker for Early Detection of Colorectal Cancer

Weisong Zhang1 Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Wuhan, 430071, People’s Republic of China
,
Chaogang Yang1 Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Wuhan, 430071, People’s Republic of China
,
Shuyi Wang1 Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Wuhan, 430071, People’s Republic of China
,
Zhenxian Xiang1 Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Wuhan, 430071, People’s Republic of China
,
Rongzhang Dou1 Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Wuhan, 430071, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-2566-7843
ORCID Icon,
Zaihuan Lin1 Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Wuhan, 430071, People’s Republic of China
,
Jinsen Zheng1 Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Wuhan, 430071, People’s Republic of China
&
Bin Xiong1 Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Wuhan, 430071, People’s Republic of ChinaCorrespondence[email protected]
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Pages 3601-3617 | Published online: 30 Apr 2021

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Ke Zhang, Qing He, Qin Cao, Jun Chuan, Ang Qin, Lin Tang, Xinyue Zhang, Changhe Xiao, Biyin Zhu, Meiling Hu, Lei Chang, Zhong xin Bu, Lanqi Fu, Ting Yang, Yu Wang & Weidong Liu. (2024) Evaluating the Clinical Performance of SDC2/NDRG4 Methylation for Colorectal Cancer Detection. Epigenomics 16:2, pages 93-108.
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Sarah Cheuk Hei Chan & Jessie Qiaoyi Liang. (2022) Advances in tests for colorectal cancer screening and diagnosis. Expert Review of Molecular Diagnostics 22:4, pages 449-460.
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Articles from other publishers (16)

Lu Long, Qian Sun, Fang Yang, Hui Zhou, Yu Wang, Changhe Xiao, Qing He & Bin Yi. (2024) Significance of SDC2 and NDRG4 methylation in stool for colorectal cancer diagnosis. Clinical Biochemistry 124, pages 110717.
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Hongying Zhao, Rongke Jiang, Zhijing Feng, Xue Wang & Chunmei Zhang. (2023) Transcription factor LHX9 (LIM Homeobox 9) enhances pyruvate kinase PKM2 activity to induce glycolytic metabolic reprogramming in cancer stem cells, promoting gastric cancer progression. Journal of Translational Medicine 21:1.
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Nima Zafari, Parsa Bathaei, Mahla Velayati, Fatemeh Khojasteh-Leylakoohi, Majid Khazaei, Hamid Fiuji, Mohammadreza Nassiri, Seyed Mahdi Hassanian, Gordon A. Ferns, Elham Nazari & Amir Avan. (2023) Integrated analysis of multi-omics data for the discovery of biomarkers and therapeutic targets for colorectal cancer. Computers in Biology and Medicine 155, pages 106639.
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Nayeralsadat Fatemi, Sascha Tierling, Hamidreza Aboulkheyr Es, Maryam Varkiani, Ehsan Nazemalhosseini Mojarad, Hamid Asadzadeh Aghdaei, Jörn Walter & Mehdi Totonchi. (2022) DNA methylation biomarkers in colorectal cancer: Clinical applications for precision medicine . International Journal of Cancer 151:12, pages 2068-2081.
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Liang Ma, Geng Qin, Fei Gai, Yongwei Jiang, Zhan Huang, Hui Yang, Shukun Yao, Shiyu Du & Yongtong Cao. (2022) A novel method for early detection of colorectal cancer based on detection of methylation of two fragments of syndecan-2 (SDC2) in stool DNA. BMC Gastroenterology 22:1.
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Ihsan Ullah, Le Yang, Feng-Ting Yin, Ye Sun, Xing-Hua Li, Jing Li & Xi-Jun Wang. (2022) Multi-Omics Approaches in Colorectal Cancer Screening and Diagnosis, Recent Updates and Future Perspectives. Cancers 14:22, pages 5545.
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Qian Ding, Xiangxu Kong, Weilong Zhong & Wentian Liu. (2022) Fecal biomarkers: Non-invasive diagnosis of colorectal cancer. Frontiers in Oncology 12.
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Faddy Kamel, Nathalie Schneider, Pasha Nisar & Mikhail Soloviev. (2022) Bottom-Up Approach to the Discovery of Clinically Relevant Biomarker Genes: The Case of Colorectal Cancer. Cancers 14:11, pages 2654.
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Rebecca L. Nance, Sara J. Cooper, Dmytro Starenki, Xu Wang, Brad Matz, Stephanie Lindley, Annette N. Smith, Ashley A. Smith, Noelle Bergman, Maninder Sandey, Jey Koehler, Payal Agarwal & Bruce F. Smith. (2022) Transcriptomic Analysis of Canine Osteosarcoma from a Precision Medicine Perspective Reveals Limitations of Differential Gene Expression Studies. Genes 13:4, pages 680.
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Faddy Kamel, Khadiga Eltarhoni, Pasha Nisar & Mikhail Soloviev. (2022) Colorectal Cancer Diagnosis: The Obstacles We Face in Determining a Non-Invasive Test and Current Advances in Biomarker Detection. Cancers 14:8, pages 1889.
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Liang Ma, Jian Gong, Meimei Zhao, Xiaomu Kong, Peng Gao, Yongwei Jiang, Yi Liu, Xiaoyan Feng, Shuang Si & Yongtong Cao. (2022) A Novel Stool Methylation Test for the Non-Invasive Screening of Gastric and Colorectal Cancer. Frontiers in Oncology 12.
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Can Fang, Rulei Zhong, Chenyang Qiu & Bing-bing Zou. (2022) The Prognostic Value of GNG7 in Colorectal Cancer and Its Relationship With Immune Infiltration. Frontiers in Genetics 13.
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Goli Siri, Samira Alesaeidi, SaeedEsmaeili Dizghandi, Behrang Alani, Meysam Mosallaei & Mohsen Soosanabadi. (2022) Analysis of SDC2 gene promoter methylation in whole blood for noninvasive early detection of colorectal cancer. Journal of Cancer Research and Therapeutics 18:9, pages 354.
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Eok-Soo Oh & John R. Couchman. 2022. The Extracellular Matrix and the Tumor Microenvironment. The Extracellular Matrix and the Tumor Microenvironment 75 92 .
Dan-yang Ren, Xin-rong Yuan, Cai-xia Tu, Jian-ling Shen, Yun-wei Li, Ai-hua Yan, Yi Ru, Hui-yun Han, Yan-ming Yang, Yan Liu & Hui-ying Li. (2021) Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases. Frontiers in Pharmacology 12.
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Sorina Andreea Anghel, Corina-Bianca Ioniță-Mîndrican, Ioana Luca & Anca Lucia Pop. (2021) Promising Epigenetic Biomarkers for the Early Detection of Colorectal Cancer: A Systematic Review. Cancers 13:19, pages 4965.
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