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Cancer Management and Research Volume 13, 2021 - Issue
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Original Research

Dynamics of Early Serum Tumour Markers and Neutrophil-to-Lymphocyte Ratio Predict Response to PD-1/PD-L1 Inhibitors in Advanced Non-Small-Cell Lung Cancer

Yin Tang1 Postgraduate Department, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, People’s Republic of China;2 Department of Oncology, The Third Affiliated Hospital of Shandong First Medical University (Affiliated Hospital of Shandong Academy of Medical Sciences), Jinan, 250031, People’s Republic of China
,
Yu Cui3 Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, People’s Republic of China;4 Shandong Lung Cancer Institute, Jinan, 250014, People’s Republic of China;5 Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Jinan, 250014, People’s Republic of China
,
Lin-lin Li6 Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, People’s Republic of China
,
Ya-ping Guan3 Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, People’s Republic of China;4 Shandong Lung Cancer Institute, Jinan, 250014, People’s Republic of China;5 Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Jinan, 250014, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-6599-5470
ORCID Icon,
Dong-feng Feng3 Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, People’s Republic of China;4 Shandong Lung Cancer Institute, Jinan, 250014, People’s Republic of China;5 Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Jinan, 250014, People’s Republic of China
,
Bei-bei Yin3 Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, People’s Republic of China;4 Shandong Lung Cancer Institute, Jinan, 250014, People’s Republic of China;5 Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Jinan, 250014, People’s Republic of China
,
Xue-feng Liang2 Department of Oncology, The Third Affiliated Hospital of Shandong First Medical University (Affiliated Hospital of Shandong Academy of Medical Sciences), Jinan, 250031, People’s Republic of China
,
Jing Yin2 Department of Oncology, The Third Affiliated Hospital of Shandong First Medical University (Affiliated Hospital of Shandong Academy of Medical Sciences), Jinan, 250031, People’s Republic of China
,
Rui Jiang6 Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, People’s Republic of China
,
Jing Liang3 Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, People’s Republic of China;4 Shandong Lung Cancer Institute, Jinan, 250014, People’s Republic of China;5 Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Jinan, 250014, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-3252-7563
ORCID Icon,
Ya-hong Sun2 Department of Oncology, The Third Affiliated Hospital of Shandong First Medical University (Affiliated Hospital of Shandong Academy of Medical Sciences), Jinan, 250031, People’s Republic of ChinaCorrespondence[email protected]
&
Jun Wang3 Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, People’s Republic of China;4 Shandong Lung Cancer Institute, Jinan, 250014, People’s Republic of China;5 Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Jinan, 250014, People’s Republic of ChinaCorrespondence[email protected]
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Pages 8241-8255 | Published online: 02 Nov 2021

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Chengliang Yuan, Meifang Huang, Huilin Wang, Wei Jiang, Cuiyun Su & Shaozhang Zhou. (2022) Pretreatment Fibrinogen-Albumin Ratio (FAR) Associated with Treatment Response and Survival in Advanced Non-Small Cell Lung Cancer Patients Treated with First-Line Anti-PD-1 Therapy Plus Platinum-Based Combination Chemotherapy. Cancer Management and Research 14, pages 377-386.
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Articles from other publishers (10)

Inga Trulson & Stefan Holdenrieder. (2024) Prognostic value of blood-based protein biomarkers in non-small cell lung cancer: A critical review and 2008–2022 update. Tumor Biology 46:s1, pages S111-S161.
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Aleksei A. Stepanenko, Anastasiia O. Sosnovtseva, Marat P. Valikhov, Anastasia A. Chernysheva, Olga V. Abramova, Konstantin A. Pavlov & Vladimir P. Chekhonin. (2024) Systemic and local immunosuppression in glioblastoma and its prognostic significance. Frontiers in Immunology 15.
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Yu Cui, Xinyue Han, Hongtao Liu, Qi Xie, Yaping Guan, Beibei Yin, Junjuan Xiao, Dongfeng Feng, Xuan Wang, Junwei Li, Jinghua Chen, Xiaolin Liu, Xingyu Li, Weiwei Nie, Lin Ma, Hairong Liu, Jing Liang, Yan Li, Baocheng Wang & Jun Wang. (2023) Impact of endogenous glucocorticoid on response to immune checkpoint blockade in patients with advanced cancer. Frontiers in Immunology 14.
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Udit Nindra, Adel Shahnam, Samuel Stevens, Abhijit Pal, Adnan Nagrial, Jenny Lee, Po Yee Yip, Tamiem Adam, Michael Boyer, Steven Kao & Victoria Bray. (2022) Elevated neutrophil‐to‐lymphocyte ratio ( NLR ) is associated with poorer progression‐free survival in unresectable stage III NSCLC treated with consolidation durvalumab . Thoracic Cancer 13:21, pages 3058-3062.
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Sara Elena Rebuzzi, Arsela Prelaj, Alex Friedlaender, Alessio Cortellini, Alfredo Addeo, Carlo Genova, Abdul Rafeh Naqash, Edouard Auclin, Laura Mezquita & Giuseppe Luigi Banna. (2022) Prognostic scores including peripheral blood-derived inflammatory indices in patients with advanced non-small-cell lung cancer treated with immune checkpoint inhibitors. Critical Reviews in Oncology/Hematology 179, pages 103806.
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Yusheng Guo, Dongqiao Xiang, Jiayu Wan, Lian Yang & Chuansheng Zheng. (2022) Focus on the Dynamics of Neutrophil-to-Lymphocyte Ratio in Cancer Patients Treated with Immune Checkpoint Inhibitors: A Meta-Analysis and Systematic Review. Cancers 14:21, pages 5297.
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Sara Elena Rebuzzi, Alessio Signori, Marco Stellato, Daniele Santini, Marco Maruzzo, Ugo De Giorgi, Paolo Pedrazzoli, Luca Galli, Paolo Andrea Zucali, Emanuela Fantinel, Claudia Carella, Giuseppe Procopio, Michele Milella, Francesco Boccardo, Lucia Fratino, Roberto Sabbatini, Riccardo Ricotta, Stefano Panni, Francesco Massari, Mariella Sorarù, Matteo Santoni, Alessio Cortellini, Veronica Prati, Hector Josè Soto Parra, Francesco Atzori, Marilena Di Napoli, Orazio Caffo, Marco Messina, Franco Morelli, Giuseppe Prati, Franco Nolè, Francesca Vignani, Alessia Cavo, Giandomenico Roviello, Miguel Angel Llaja Obispo, Camillo Porta, Sebastiano Buti, Giuseppe Fornarini & Giuseppe Luigi Banna. (2022) The prognostic value of baseline and early variations of peripheral blood inflammatory ratios and their cellular components in patients with metastatic renal cell carcinoma treated with nivolumab: The Δ-Meet-URO analysis. Frontiers in Oncology 12.
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David A. Barrington, Corinne Calo, Jae Baek, Morgan Brown, Vincent Wagner, Lynette Gonzalez, Allison Huffman, Jason Benedict & Kristin Bixel. (2022) Beyond mismatch repair deficiency? Pre-treatment neutrophil-to-lymphocyte ratio is associated with improved overall survival in patients with recurrent endometrial cancer treated with immunotherapy. Gynecologic Oncology 166:3, pages 522-529.
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Yaping Guan, Dongfeng Feng, Beibei Yin, Kun Li & Jun Wang. (2022) Immune-related dissociated response as a specific atypical response pattern in solid tumors with immune checkpoint blockade. Therapeutic Advances in Medical Oncology 14, pages 175883592210968.
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