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International Journal of Chronic Obstructive Pulmonary Disease Volume 12, 2017 - Issue
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Original Research

A pilot clinical trial to determine the safety and efficacy of aerosolized hyaluronan as a treatment for COPD

Jerome Cantor1 Department of Pharmaceutical Sciences, St John’s UniversityCorrespondence[email protected]
,
Shuren Ma2 Department of Medicine, St Luke’s Mount Sinai Hospital Center, New York, NY, USA
&
Gerard Turino2 Department of Medicine, St Luke’s Mount Sinai Hospital Center, New York, NY, USA
Pages 2747-2752 | Published online: 18 Sep 2017

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Read on this site (2)

Anita Pye & Alice M Turner. (2019) Experimental and investigational drugs for the treatment of alpha-1 antitrypsin deficiency. Expert Opinion on Investigational Drugs 28:10, pages 891-902.
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Rob Janssen, Ianthe Piscaer, Frits M. E. Franssen & Emiel F. M. Wouters. (2019) Emphysema: looking beyond alpha-1 antitrypsin deficiency. Expert Review of Respiratory Medicine 13:4, pages 381-397.
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Articles from other publishers (19)

Sara Stoilova, Walter Fiore, Valentina Trotta & Michela Mori. (2023) Performance and biocompatibility of a novel inhalable dry powder formulation based on hyaluronic acid intended to protect the respiratory tract mucosa. International Journal of Pharmaceutics 638, pages 122889.
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Alice Donato, Federico Fontana, Rina Venerando, Antonino Di Stefano & Paola Brun. (2023) The Anti-Inflammatory Effect of Lactose-Modified Hyaluronic Acid Molecules on Primary Bronchial Fibroblasts of Smokers. Polymers 15:7, pages 1616.
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Anzhu Wang, Zhendong Li, Zhuo Sun, Yicheng Liu, Dawu Zhang & Xiaochang Ma. (2023) Potential Mechanisms Between HF and COPD: New Insights From Bioinformatics. Current Problems in Cardiology 48:3, pages 101539.
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Henry W. Barnes, Sally Demirdjian, Naomi L. Haddock, Gernot Kaber, Hunter A. Martinez, Nadine Nagy, Harry Karmouty-Quintana & Paul L. Bollyky. (2023) Hyaluronan in the pathogenesis of acute and post-acute COVID-19 infection. Matrix Biology 116, pages 49-66.
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Kathryn M. Crotty & Samantha M. Yeligar. (2022) Hyaladherins May be Implicated in Alcohol-Induced Susceptibility to Bacterial Pneumonia. Frontiers in Immunology 13.
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Stavros Garantziotis. (2022) Modulation of hyaluronan signaling as a therapeutic target in human disease. Pharmacology & Therapeutics 232, pages 107993.
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Jerome O. Cantor, Shuren Ma, Xingjian Liu, Michael A. Campos, Charlton Strange, James M. Stocks, Megan S. Devine, Sherif G. El Bayadi, Randolph J. Lipchik, Robert A. Sandhaus & Gerard M. Turino. (2021) A 28-day clinical trial of aerosolized hyaluronan in alpha-1 antiprotease deficiency COPD using desmosine as a surrogate marker for drug efficacy. Respiratory Medicine 182, pages 106402.
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Khushboo Goel, Charlie Strange, Robert A Sandhaus, Irina Petrache & Karina A Serban. (2021) Updates in the Management of Alpha-1 Antitrypsin Deficiency Lung Disease. US Respiratory & Pulmonary Diseases 6:1, pages 26.
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Meropi Karakioulaki, Eleni Papakonstantinou & Daiana Stolz. (2020) Extracellular matrix remodelling in COPD. European Respiratory Review 29:158, pages 190124.
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Sara J. Bonvini. (2020) Cause or Effect? Stretching to Understand the Inflammatory Role of Elastin Fiber Breakdown in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory Cell and Molecular Biology 63:5, pages 558-559.
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Shadi Mehraban, George Gu, Shuren Ma, Xingjian Liu, Gerard Turino & Jerome Cantor. (2020) The Proinflammatory Activity of Structurally Altered Elastic Fibers. American Journal of Respiratory Cell and Molecular Biology 63:5, pages 699-706.
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Luis Máiz Carro & Miguel A. Martínez-García. (2020) Use of Hyaluronic Acid (HA) in Chronic Airway Diseases. Cells 9:10, pages 2210.
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Maria Di Cicco, Diego Peroni, Margherita Sepich, Maria Giulia Tozzi, Pasquale Comberiati & Renato Cutrera. (2020) Hyaluronic acid for the treatment of airway diseases in children: Little evidence for few indications. Pediatric Pulmonology 55:8, pages 2156-2169.
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Jiapeng Xue, Jinnan Chen, Quan Shen, Deva Chan, Jun Li, Adam P. Tanguay, Tannin A. Schmidt, Faizan Niazi & Anna Plaas. (2020) Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican. Cells 9:7, pages 1681.
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Jerome O. Cantor & Gerard M. Turino. (2019) COPD Pathogenesis. Chest 155:2, pages 266-271.
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Jerome Cantor. (2018) Giants in Chest Medicine: Gerard M. Turino, MD. Chest 154:6, pages 1274-1275.
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Beatriz Herrero-CortinaVictoria AlcarazJordi VilaróAntoni TorresEva Polverino. (2018) Impact of Hypertonic Saline Solutions on Sputum Expectoration and Their Safety Profile in Patients with Bronchiectasis: A Randomized Crossover Trial. Journal of Aerosol Medicine and Pulmonary Drug Delivery 31:5, pages 281-289.
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Gerard M. Turino, Shuren Ma, Yong Y. Lin & Jerome O. Cantor. (2018) The Therapeutic Potential of Hyaluronan in COPD. Chest 153:4, pages 792-798.
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Gerard M. Turino. (2018) Chronic Obstructive Pulmonary Disease. A Biomarker and a Potential Therapy. Annals of the American Thoracic Society 15:Supplement_1, pages S15-S17.
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