Phenotyping and outcomes of hospitalized COPD patients using rapid molecular diagnostics on sputum samples

Nawaf M Alotaibi1 Centre for Heart Lung Innovation, James Hogg Research Centre, St Paul’s Hospital, Vancouver, BC, Canada, [email protected];2 Department of Medicine, Division of Pulmonary Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia

Virginia Chen1 Centre for Heart Lung Innovation, James Hogg Research Centre, St Paul’s Hospital, Vancouver, BC, Canada, [email protected];3 Institute for Heart and Lung Health, Vancouver, BC, Canada, [email protected];4 PROOF Centre of Excellence, Vancouver, BC, Canada

Zsuzsanna Hollander1 Centre for Heart Lung Innovation, James Hogg Research Centre, St Paul’s Hospital, Vancouver, BC, Canada, [email protected];3 Institute for Heart and Lung Health, Vancouver, BC, Canada, [email protected];4 PROOF Centre of Excellence, Vancouver, BC, Canada

Jonathon A Leipsic5 Department of Radiology, St Paul’s Hospital, Vancouver, BC, Canada

Cameron J Hague5 Department of Radiology, St Paul’s Hospital, Vancouver, BC, Canada

Darra T Murphy5 Department of Radiology, St Paul’s Hospital, Vancouver, BC, Canada

Mari L DeMarco1 Centre for Heart Lung Innovation, James Hogg Research Centre, St Paul’s Hospital, Vancouver, BC, Canada, [email protected];6 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

JM FitzGerald3 Institute for Heart and Lung Health, Vancouver, BC, Canada, [email protected];7 Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada, [email protected];8 The Lung Centre, Vancouver General Hospital, Vancouver, BC, Canada

Bruce M McManus1 Centre for Heart Lung Innovation, James Hogg Research Centre, St Paul’s Hospital, Vancouver, BC, Canada, [email protected];3 Institute for Heart and Lung Health, Vancouver, BC, Canada, [email protected];4 PROOF Centre of Excellence, Vancouver, BC, Canada;6 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

Raymond T Ng4 PROOF Centre of Excellence, Vancouver, BC, Canada;9 Department of Computer Sciences, University of British Columbia, Vancouver, BC, Canada

Don D Sin1 Centre for Heart Lung Innovation, James Hogg Research Centre, St Paul’s Hospital, Vancouver, BC, Canada, [email protected];3 Institute for Heart and Lung Health, Vancouver, BC, Canada, [email protected];7 Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada, [email protected]Correspondence[email protected]

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Ruan Spies, Matthew Potter, Ruan Hollamby, Stefan van der WaltAmeer Hohlfeld, Eleanor Ochodo & Richard Van Zyl-Smit. (2023) Sputum Color as a Marker for Bacteria in Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis. Annals of the American Thoracic Society 20:5, pages 738-748.
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Hyun Lee, Cara Kovacs, Andre Mattman, Zsuzsanna Hollander, Virginia Chen, Raymond Ng, Janice M. Leung & Don D. Sin. (2022) The impact of IgG subclass deficiency on the risk of mortality in hospitalized patients with COPD. Respiratory Research 23:1.
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Daiana Stolz, Takudzwa Mkorombindo, Desiree M Schumann, Alvar Agusti, Samuel Y Ash, Mona Bafadhel, Chunxue Bai, James D Chalmers, Gerard J Criner, Shyamali C Dharmage, Frits M E Franssen, Urs Frey, MeiLan Han, Nadia N Hansel, Nathaniel M Hawkins, Ravi Kalhan, Melanie Konigshoff, Fanny W Ko, Trisha M Parekh, Pippa Powell, Maureen Rutten-van Mölken, Jodie Simpson, Don D Sin, Yuanlin Song, Bela Suki, Thierry Troosters, George R Washko, Tobias Welte & Mark T Dransfield. (2022) Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission. The Lancet 400:10356, pages 921-972.
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Ching Leng Tan, Yinghan Chan, Mayuren Candasamy, Jestin Chellian, Thiagarajan Madheswaran, Lakshmana Prabu Sakthivel, Vyoma K. Patel, Amlan Chakraborty, Ronan MacLoughlin, Deepak Kumar, Nitin Verma, Vamshikrishna Malyla, Piyush Kumar Gupta, Niraj Kumar Jha, Lakshmi Thangavelu, Hari Prasad Devkota, Shvetank Bhatt, Parteek Prasher, Gaurav Gupta, Monica Gulati, Sachin Kumar Singh, Keshav Raj Paudel, Philip M. Hansbro, Brian G. Oliver, Kamal Dua & Dinesh Kumar Chellappan. (2022) Unravelling the molecular mechanisms underlying chronic respiratory diseases for the development of novel therapeutics via in vitro experimental models. European Journal of Pharmacology 919, pages 174821.
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Nawaf M. Alotaibi, Fernando Sergio Leitao Filho, Andre Mattman, Zsuzsanna Hollander, Virginia Chen, Raymond Ng, Janice M. Leung & Don D. Sin. (2021) IgG Levels and Mortality in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine 204:3, pages 362-365.
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Alison J. Dicker, Jeffrey T.J. Huang, Mike Lonergan, Holly R. Keir, Christopher J. Fong, Brandon Tan, Andrew J. Cassidy, Simon Finch, Hana Mullerova, Bruce E. Miller, Ruth Tal-Singer & James D. Chalmers. (2021) The sputum microbiome, airway inflammation, and mortality in chronic obstructive pulmonary disease. Journal of Allergy and Clinical Immunology 147:1, pages 158-167.
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Vanessa M McDonald, Christian R Osadnik & Peter G Gibson. (2019) Treatable traits in acute exacerbations of chronic airway diseases. Chronic Respiratory Disease 16, pages 147997311986795.
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Phenotyping and outcomes of hospitalized COPD patients using rapid molecular diagnostics on sputum samples

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Phenotyping and outcomes of hospitalized COPD patients using rapid molecular diagnostics on sputum samples

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