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International Journal of Chronic Obstructive Pulmonary Disease Volume 14, 2019 - Issue
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Original Research

Dual Role For A MEK Inhibitor As A Modulator Of Inflammation And Host Defense Mechanisms With Potential Therapeutic Application In COPD

Nisha Kurian1 Respiratory Inflammation and Autoimmune (RIA) Precision Medicine Unit, Precision Medicine, Oncology R&D, AstraZeneca, Gothenburg, SwedenCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8384-9928
ORCID Icon,
Taylor S Cohen2 Microbial Sciences, Medimmune, Gaithersburg, MD, USA
,
Lisa Öberg3 Translational Science and Experimental Medicine, Research and Early Development, RIA, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, SwedenORCID Iconhttps://orcid.org/0000-0001-7127-1711
ORCID Icon,
Erica De Zan3 Translational Science and Experimental Medicine, Research and Early Development, RIA, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
,
Gabriel Skogberg4 Bioscience, Research and Early Development, RIA, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
,
Stefan Vollmer3 Translational Science and Experimental Medicine, Research and Early Development, RIA, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
,
Engin Baturcam3 Translational Science and Experimental Medicine, Research and Early Development, RIA, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, SwedenORCID Iconhttps://orcid.org/0000-0001-5879-6329
ORCID Icon,
Petter Svanberg5 Drug Metabolism and Pharmacokinetics, Research and Early Development, RIA, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
,
Britta Bonn5 Drug Metabolism and Pharmacokinetics, Research and Early Development, RIA, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
,
Paul D Smith6 Bioscience, Oncology R&D, AstraZeneca, Cambridge, UK
,
Outi Vaarala3 Translational Science and Experimental Medicine, Research and Early Development, RIA, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
&
Danen M Cunoosamy3 Translational Science and Experimental Medicine, Research and Early Development, RIA, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
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Pages 2611-2624 | Published online: 26 Nov 2019

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Netsanet A Negewo, Peter G Gibson, Jodie L Simpson, Vanessa M McDonald & Katherine J Baines. (2023) Severity of Lung Function Impairment Drives Transcriptional Phenotypes of COPD and Relates to Immune and Metabolic Processes. International Journal of Chronic Obstructive Pulmonary Disease 18, pages 273-287.
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Articles from other publishers (7)

Mengjuan Lin, Guiying Hu & Baoping Yu. (2022) Dysregulated cystathionine‐β‐synthase/hydrogen sulfide signaling promotes chronic stress‐induced colonic hypermotility in rats. Neurogastroenterology & Motility 35:2.
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Hiroyuki Muranushi, Takero Shindo, Toyofumi F Chen-Yoshikawa, Akihiko Yoshizawa, Huong Thi Ngo, Fumiaki Gochi, Hiroshi Date & Akifumi Takaori-Kondo. (2023) Dual inhibition of the MEK/ERK and PI3K/AKT pathways prevents pulmonary GVHD suppressing perivenulitis and bronchiolitis. Blood Advances 7:1, pages 106-121.
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Nathaniel McClean, Jeffery D. Hasday & Paul Shapiro. 2023. Pulmonary Pharmacology. Pulmonary Pharmacology 145 178 .
Eunhui Kim, Hae Kyung Mok & Tae Kyung Hyun. (2022) Variations in the Antioxidant, Anticancer, and Anti-Inflammatory Properties of Different Rosa rugosa Organ Extracts. Agronomy 12:2, pages 238.
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Jie Xiong, Xingyi Kuang, Tingting Lu, Kunlin Yu, Xu Liu, Zhaoyuan Zhang, Weili Wang, Lu Zhao, Qin Fang, Depei Wu & Jishi Wang. (2020) C3a and C5a facilitates the metastasis of myeloma cells by activating Nrf2. Cancer Gene Therapy 28:3-4, pages 265-278.
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Paolo Di Fruscia, Fredrik Edfeldt, Igor Shamovsky, Gavin W. Collie, Anna Aagaard, Louise Barlind, Ulf Börjesson, Eva L. Hansson, Richard J. Lewis, Magnus K. Nilsson, Linda Öster, Josefine Pemberton, Lena Ripa, R. Ian Storer & Helena Käck. (2021) Fragment-Based Discovery of Novel Allosteric MEK1 Binders. ACS Medicinal Chemistry Letters 12:2, pages 302-308.
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Lanlan Zhou, Kelsey Huntington, Shengliang Zhang, Lindsey Carlsen, Eui-Young So, Cassandra Parker, Ilyas Sahin, Howard Safran, Suchitra Kamle, Chang-Min Lee, Chun Geun Lee, Jack A. Elias, Kerry S. Campbell, Mandar T. Naik, Walter J. Atwood, Emile Youssef, Jonathan A. Pachter, Arunasalam Navaraj, Attila A. Seyhan, Olin Liang & Wafik S. El-Deiry. (2020) MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection. Oncotarget 11:46, pages 4201-4223.
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