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International Journal of Chronic Obstructive Pulmonary Disease Volume 15, 2020 - Issue
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Original Research

Glucocorticoid Receptor α Mediates Roflumilast’s Ability to Restore Dexamethasone Sensitivity in COPD

Aravind T Reddy1 Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA15213, USA;2 Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA15240, USA
,
Sowmya P Lakshmi1 Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA15213, USA;2 Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA15240, USA
,
Asoka Banno1 Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA15213, USA
&
Raju C Reddy1 Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA15213, USA;2 Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA15240, USACorrespondence[email protected]
Pages 125-134 | Published online: 14 Jan 2020

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Maria Gabriella Matera, Josuel Ora, Francesco Cavalli, Paola Rogliani & Mario Cazzola. (2021) New Avenues for Phosphodiesterase Inhibitors in Asthma. Journal of Experimental Pharmacology 13, pages 291-302.
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Articles from other publishers (10)

Huanming Huang, Wenqing Wang, Yu Cui, Cai-Xia Hu & Ming Du. (2023) Correlation between nuclear expression of heat shock protein 90 in dermis and glucocorticoid resistance in bullous dermatosis. Steroids 194, pages 109223.
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Pengcheng Zhou, Jianli Ma, Wei Yu, Keling Chen, Wensheng Zhang & Jiang Zhou. (2023) Tiao-Bu-Fei-Shen Formula Improves Glucocorticoid Resistance of Chronic Obstructive Pulmonary Disease via Downregulating the PI3K-Akt Signaling Pathway and Promoting GRα Expression. Evidence-Based Complementary and Alternative Medicine 2023, pages 1-17.
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Huanming Huang & Wenqing Wang. (2022) Molecular mechanisms of glucocorticoid resistance. European Journal of Clinical Investigation 53:2.
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Ravi Mishra, Zia Hashim, Mansi Gupta, Rachna Chaturvedi, Harshit Singh, Alok Nath, DurgaPrasanna Misra, Ajmal Khan, MohitKumar Rai, Shivani Srivastava, Saurabh Chaturvedi & Vikas Agarwal. (2022) Histone deacetylase-2 inducer like theophylline has a potential to improve glucocorticoid responsiveness in severe uncontrolled asthma by reducing P-glycoprotein/MRP-1. Indian Journal of Rheumatology 17:1, pages 47.
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Brandon W. Lewis, Maria L. Ford, Lynette K. Rogers & Rodney D. BrittJr.Jr.. (2021) Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants 10:9, pages 1335.
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Mark J. Turner, Nurlan Dauletbaev, Larry C. Lands & John W. Hanrahan. (2020) The Phosphodiesterase Inhibitor Ensifentrine Reduces Production of Proinflammatory Mediators in Well Differentiated Bronchial Epithelial Cells by Inhibiting PDE4. Journal of Pharmacology and Experimental Therapeutics 375:3, pages 414-429.
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Manar Mohammed El Tabaa & Maram Mohammed El Tabaa. (2020) New putative insights into neprilysin (NEP)-dependent pharmacotherapeutic role of roflumilast in treating COVID-19. European Journal of Pharmacology 889, pages 173615.
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Shradha Bodkhe, Mayuri Nikam, Atul P. Sherje, Tabassum Khan, Vasanti Suvarna & Kavit Patel. (2020) Current insights on clinical efficacy of roflumilast for treatment of COPD, asthma and ACOS. International Immunopharmacology 88, pages 106906.
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Aravind T. Reddy, Sowmya P. Lakshmi, E. Maruthi Prasad, N.Ch. Varadacharyulu & Lakshmi Devi Kodidhela. (2020) Epigallocatechin gallate suppresses inflammation in human coronary artery endothelial cells by inhibiting NF-κB. Life Sciences 258, pages 118136.
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Andrew Higham, Tom ScottJian LiRosemary GaskellAisha Baba DikwaRajesh ShahM. Angeles Montero-FernandezSimon LeaDave Singh. (2020) Effects of corticosteroids on COPD lung macrophage phenotype and function. Clinical Science 134:7, pages 751-763.
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