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International Journal of Chronic Obstructive Pulmonary Disease Volume 16, 2021 - Issue
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Original Research

Exploring PI3Kδ Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials

Malcolm Begg1 Refractory Respiratory Inflammation Discovery Performance Unit, GlaxoSmithKline, Stevenage, UKCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9508-3424View further author information
ORCID Icon,
J Nicole Hamblin1 Refractory Respiratory Inflammation Discovery Performance Unit, GlaxoSmithKline, Stevenage, UKView further author information
,
Emily Jarvis2 Biostatistics, GlaxoSmithKline R&D, Stevenage, UKORCID Iconhttps://orcid.org/0000-0001-7187-6382View further author information
ORCID Icon,
Glyn Bradley3 Computational Biology, Medicinal Science and Technology, GlaxoSmithKline, Stevenage, UKView further author information
,
Stephen Mark4 Study Management, Clinical Development, GlaxoSmithKline, Mississauga, ON, CanadaView further author information
,
David Michalovich5 Adaptive Immunity Research Unit, GlaxoSmithKline, Stevenage, UKView further author information
,
Mark Lennon6 Nonclinical and Translational Statistics, GlaxoSmithKline, Stevenage, UKView further author information
,
Hannah E Wajdner5 Adaptive Immunity Research Unit, GlaxoSmithKline, Stevenage, UKView further author information
,
Augustin Amour5 Adaptive Immunity Research Unit, GlaxoSmithKline, Stevenage, UKView further author information
,
Robert Wilson1 Refractory Respiratory Inflammation Discovery Performance Unit, GlaxoSmithKline, Stevenage, UKView further author information
,
Ken Saunders5 Adaptive Immunity Research Unit, GlaxoSmithKline, Stevenage, UKView further author information
,
Rikako Tanaka7 Data Management & Strategy, Clinical Development, GlaxoSmithKline, Tokyo, JapanView further author information
,
Saki Arai7 Data Management & Strategy, Clinical Development, GlaxoSmithKline, Tokyo, JapanView further author information
,
Teresa Tang8 Pharma Safety, Clinical Development, GlaxoSmithKline, Brentford, Middlesex, UKView further author information
,
Cedric Van Holsbeke9 FLUIDDA nv, Kontich, 2550, BelgiumORCID Iconhttps://orcid.org/0000-0003-0248-841XView further author information
ORCID Icon,
Jan De Backer9 FLUIDDA nv, Kontich, 2550, BelgiumView further author information
,
Wim Vos9 FLUIDDA nv, Kontich, 2550, BelgiumView further author information
,
Ingrid L Titlestad10 Department of Respiratory Medicine, Odense University Hospital and University of Southern Denmark, Odense, DenmarkORCID Iconhttps://orcid.org/0000-0001-6418-0088View further author information
ORCID Icon,
J Mark FitzGerald11 Centre for Heart and Lung Health, University of British Columbia, Vancouver, BC, CanadaView further author information
,
Kieran Killian12 Cardiorespiratory Research Laboratory, Faculty of Health Sciences, McMaster University, Hamilton, ON, CanadaView further author information
,
Jean Bourbeau13 Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, QC, CanadaView further author information
,
Claude Poirier14 Department of Medicine, Respiratory Medicine Division, University of Montreal, Montreal, QC, CanadaView further author information
,
François Maltais15 Institut Universitaire de Cardiologie et de Pneumologie de Québe, Université Laval, Quebec City, QC, CanadaORCID Iconhttps://orcid.org/0000-0002-6809-4651View further author information
ORCID Icon,
Anthony Cahn1 Refractory Respiratory Inflammation Discovery Performance Unit, GlaxoSmithKline, Stevenage, UKView further author information
&
Edith M Hessel1 Refractory Respiratory Inflammation Discovery Performance Unit, GlaxoSmithKline, Stevenage, UKORCID Iconhttps://orcid.org/0000-0002-2339-4482View further author information
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Pages 1621-1636 | Published online: 03 Jun 2021

Citations (10)

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Read on this site (3)

Mario Cazzola, Nicola A Hanania, Clive P Page & Maria Gabriella Matera. (2023) Novel Anti-Inflammatory Approaches to COPD. International Journal of Chronic Obstructive Pulmonary Disease 18, pages 1333-1352.
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Netsanet A Negewo, Peter G Gibson, Jodie L Simpson, Vanessa M McDonald & Katherine J Baines. (2023) Severity of Lung Function Impairment Drives Transcriptional Phenotypes of COPD and Relates to Immune and Metabolic Processes. International Journal of Chronic Obstructive Pulmonary Disease 18, pages 273-287.
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Peng Guo, Rui Li, Tie Hua Piao, Chun Lan Wang, Xiao Lu Wu & Hong Yan Cai. (2022) Pathological Mechanism and Targeted Drugs of COPD. International Journal of Chronic Obstructive Pulmonary Disease 17, pages 1565-1575.
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Articles from other publishers (7)

Malcolm Begg, Augustin Amour, Emily Jarvis, Teresa Tang, Sara Santos Franco, Andrew Want, Misba Beerahee, Disala Fernando, Yakshitha Karkera, Clare Sander, Thomas Southworth, Dave Singh, Jonathan Clark, Sergey Nejentsev, Klaus Okkenhaug, Alison Condliffe, Anita Chandra, Anthony Cahn & Edward Banham Hall. (2023) An open label trial of nemiralisib, an inhaled PI3 kinase delta inhibitor for the treatment of Activated PI3 kinase Delta Syndrome. Pulmonary Pharmacology & Therapeutics 79, pages 102201.
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Maria Antonietta Occhiuzzi, Gernando Lico, Giuseppina Ioele, Michele De Luca, Antonio Garofalo & Fedora Grande. (2023) Recent advances in PI3K/PKB/mTOR inhibitors as new anticancer agents. European Journal of Medicinal Chemistry 246, pages 114971.
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Nathaniel McClean, Jeffery D. Hasday & Paul Shapiro. 2023. Pulmonary Pharmacology. Pulmonary Pharmacology 145 178 .
Isabel UWAGBOE, Ian M. ADCOCK, Federica LO BELLO, Gaetano CARAMORI & Sharon MUMBY. (2022) New drugs under development for COPD. Minerva Medica 113:3.
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Harshada Desai, Megha Marathe, Varada Potdar, Prabhakar Tiwari, Ashwini Joshi, Sheetal R. Kadam, Arti Rajesh Joshi, Abhay Kulkarni, Vikram Bhosale, Avinash Hadambar, Bhavik Lodhiya, Venkatesha Udupa, Dayanidhi Behera, Sachin S. Chaudhari, Sanjib Das, Malini Bajpai, Nagaraj Gowda & Pravin S. Iyer. (2022) An inhibitor of RORγ for chronic pulmonary obstructive disease treatment. Scientific Reports 12:1.
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Mario Cazzola, Josuel Ora, Luigino Calzetta, Paola Rogliani & Maria Gabriella Matera. (2022) The future of inhalation therapy in chronic obstructive pulmonary disease. Current Research in Pharmacology and Drug Discovery 3, pages 100092.
Crossref
Kyle T. Mincham, Nicoletta Bruno, Aran Singanayagam & Robert J. Snelgrove. (2021) Our evolving view of neutrophils in defining the pathology of chronic lung disease. Immunology 164:4, pages 701-721.
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