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International Journal of Chronic Obstructive Pulmonary Disease Volume 10, 2015 - Issue
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Original Research

Reversal of corticosteroid insensitivity by p38 MAPK inhibition in peripheral blood mononuclear cells from COPD

Nadia Khorasani1 Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College and Biomedical Research Unit, Royal Brompton and Harefield NHS Trust Hospital, London, UK
,
Josephine Baker1 Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College and Biomedical Research Unit, Royal Brompton and Harefield NHS Trust Hospital, London, UK
,
Malcolm Johnson2 GlaxoSmithKline, Uxbridge, UK
,
Kian Fan Chung1 Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College and Biomedical Research Unit, Royal Brompton and Harefield NHS Trust Hospital, London, UK
&
Pankaj K Bhavsar1 Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College and Biomedical Research Unit, Royal Brompton and Harefield NHS Trust Hospital, London, UKCorrespondence[email protected]
Pages 283-291 | Published online: 04 Feb 2015

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Irina R. Strâmbu, Zhanna D. Kobalava, Baldur P. Magnusson, Alastair MacKinnon & Jacqueline M. Parkin. (2019) Phase II Study of Single/Repeated Doses of Acumapimod (BCT197) to Treat Acute Exacerbations of COPD. COPD: Journal of Chronic Obstructive Pulmonary Disease 16:5-6, pages 344-353.
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Andrew Higham, Pradeep Karur, Natalie Jackson, Danen M Cunoosamy, Paul Jansson & Dave Singh. (2018) Differential anti-inflammatory effects of budesonide and a p38 MAPK inhibitor AZD7624 on COPD pulmonary cells. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 1279-1288.
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Neil C. Thomson. (2016) Addressing corticosteroid insensitivity in adults with asthma. Expert Review of Respiratory Medicine 10:2, pages 137-156.
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Igor Z Barjaktarevic, Anthony F Arredondo & Christopher B Cooper. (2015) Positioning new pharmacotherapies for COPD. International Journal of Chronic Obstructive Pulmonary Disease 10, pages 1427-1442.
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Articles from other publishers (8)

Haichuan Yu, Xiaojie Su, Ting Lei, Lu Zhang, Zhouzhou Feng, Chuchu Zhang, Meng Zhang, Yalei Wang, Xinlong Chen & Jian Liu. (2022) Safety and efficacy of p38 mitogen-activated protein kinase inhibitors (MAPKIs) in COPD. Frontiers in Pharmacology 13.
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Elisabetta Armani, Carmelida Capaldi, Valentina Bagnacani, Francesca Saccani, Giancarlo Aquino, Paola Puccini, Fabrizio Facchinetti, Cataldo Martucci, Nadia Moretto, Gino Villetti, Riccardo Patacchini, Maurizio Civelli, Chris Hurley, Andrew Jennings, Lilian Alcaraz, Dawn Bloomfield, Michael Briggs, Stephen Daly, Terry Panchal, Vince Russell, Sharon Wicks, Harry Finch, Mary Fitzgerald, Craig Fox & Maurizio Delcanale. (2022) Design, Synthesis, and Biological Characterization of Inhaled p38α/β MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases. Journal of Medicinal Chemistry 65:10, pages 7170-7192.
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Lisa Zeyen, Ole Morten Seternes & Ingvild Mikkola. (2022) Crosstalk between p38 MAPK and GR Signaling. International Journal of Molecular Sciences 23:6, pages 3322.
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A. G. Kadushkin, A. D. Taganovich, L. V. Movchan, E. I. Talabaeva, A. V. Plastinina & T. V. Shman. (2021) Effect of the combination of theophylline and budesonide on production of proinflammatory cytokines by blood cells of patients with chronic obstructive pulmonary disease. Tuberculosis and Lung Diseases 99:10, pages 14-22.
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Brandon W. Lewis, Maria L. Ford, Lynette K. Rogers & Rodney D. BrittJr.Jr.. (2021) Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants 10:9, pages 1335.
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Yang Yang, Xin Jin, Xinyi Jiao, Jinjing Li, Liuyi Liang, Yuanyuan Ma, Rui Liu & Zheng Li. (2020) Advances in Pharmacological Actions and Mechanisms of Flavonoids from Traditional Chinese Medicine in Treating Chronic Obstructive Pulmonary Disease. Evidence-Based Complementary and Alternative Medicine 2020, pages 1-10.
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A. G. Kadushkin, A. D. Taganovich, A. A. Arabey, L. M. Shishlo, A. P. Lyubetskaya & L. V. Aleshkevich. (2018) Sensitivity to glucocorticosteroids and heterogeneity of in vitro cell response in patients with chronic obstructive pulmonary disease. Russian Pulmonology 28:5, pages 558-566.
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Andrew Higham, George Booth, Simon Lea, Thomas Southworth, Jonathan Plumb & Dave Singh. (2015) The effects of corticosteroids on COPD lung macrophages: a pooled analysis. Respiratory Research 16:1.
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