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Clinical Pharmacology: Advances and Applications Volume 6, 2014 - Issue

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Original Research

Enantiomer-selective pharmacokinetics, oral bioavailability, and sex effects of various alpha-lipoic acid dosage forms

Robert Hermann1 Clinical Research Appliance (cr appliance), Gelnhausen, GermanyCorrespondence[email protected]

Julius Mungo2 MEDA Pharma GmbH & Co KG, Bad Homburg, Germany

Peter Jürgen Cnota2 MEDA Pharma GmbH & Co KG, Bad Homburg, Germany

Dan Ziegler3 Institute for Clinical Diabetology, German Diabetes Center, Heinrich Heine University, Düsseldorf, Germany

Pages 195-204 | Published online: 28 Nov 2014

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Qingxiu Liu, Wenxiang Li, Shimeng Huang, Lihong Zhao, Jianyun Zhang, Cheng Ji & Qiugang Ma. (2022) R- Is Superior to S-Form of α-Lipoic Acid in Anti-Inflammatory and Antioxidant Effects in Laying Hens. Antioxidants 11:8, pages 1530.
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Luc Rochette & Steliana Ghibu. (2021) Mechanics Insights of Alpha-Lipoic Acid against Cardiovascular Diseases during COVID-19 Infection. International Journal of Molecular Sciences 22:15, pages 7979.
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Dominique Turck, Jacqueline Castenmiller, Stefaan de Henauw, Karen Ildico Hirsch‐Ernst, John Kearney, Helle Katrine Knutsen, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Daniele Cappellani, Richard Ijzerman, Henk Van Loveren, Ariane Titz & Alexandre Maciuk. (2021) Scientific opinion on the relationship between intake of alpha‐lipoic acid (thioctic acid) and the risk of insulin autoimmune syndrome. EFSA Journal 19:6.
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Anca Pop, Simona Crișan, Maria Bârcă, Anne-Marie Ciobanu, Valentin Varlas, Coriolan Pop, Mariana-Ana Pali, Dumitru Cauni, Emma Ozon, Denisa Udeanu, Simona Trifu & Bogdana Năsui. (2021) Evaluation of Dissolution Profiles of a Newly Developed Solid Oral Immediate-Release Formula Containing Alpha-Lipoic Acid. Processes 9:1, pages 176.
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Daniely V. S. Costa, Deiziane V. S. Costa, Caren N. S. Sousa, Angeline M. H. P. Silva, Ingridy S. Medeiros, Dainesy S. Martins, Conceição S. Martins, Ana L. V. Pequeno, Roberto C. P. Lima-Júnior, Pedro M. G. Soares, Silvânia M. M. Vasconcelos, Gerly A. C. Brito & Emmanuel P. Souza. (2020) The Alpha-Lipoic Acid Improves Survival and Prevents Irinotecan-Induced Inflammation and Intestinal Dysmotility in Mice. Pharmaceuticals 13:11, pages 361.
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Elena Lucarini, Elena Trallori, Daniele Tomassoni, Francesco Amenta, Carla Ghelardini, Alessandra Pacini & Lorenzo Di Cesare Mannelli. (2020) Toxicological Profile of the Pain-Relieving Antioxidant Compound Thioctic Acid in Its Racemic and Enantiomeric Forms. Antioxidants 9:8, pages 749.
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Bahare Salehi, Yakup Berkay Yılmaz, Gizem Antika, Tugba Boyunegmez Tumer, Mohamad Fawzi Mahomoodally, Devina Lobine, Muhammad Akram, Muhammad Riaz, Esra Capanoglu, Farukh Sharopov, Natália Martins, William C. Cho & Javad Sharifi-Rad. (2019) Insights on the Use of α-Lipoic Acid for Therapeutic Purposes. Biomolecules 9:8, pages 356.
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Caren Nádia Soares de Sousa, Cláudio Manuel Gonçalves da Silva Leite, Ingridy da Silva Medeiros, Luna Costa Vasconcelos, Lucas Moraes Cabral, Cláudio Felipe Vasconcelos Patrocínio, Marianna Letícia Vasconcelos Patrocínio, Fayçal Mouaffak, Oussama Kebir, Danielle Macedo, Manoel Cláudio Azevedo Patrocínio & Silvânia Maria Mendes Vasconcelos. (2018) Alpha-lipoic acid in the treatment of psychiatric and neurological disorders: a systematic review. Metabolic Brain Disease 34:1, pages 39-52.
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Caren Nádia Soares de Sousa, Lucas Nascimento Meneses, Germana Silva Vasconcelos, Ingridy da Silva Medeiros, Márcia Calheiros Chaves Silva, Fayçal Mouaffak, Oussama Kebir, Cláudio Manuel Gonçalves da Silva Leite, Manoel Cláudio Azevedo Patrocinio, Danielle Macedo & Silvânia Maria Mendes Vasconcelos. (2018) Neuroprotective evidence of alpha-lipoic acid and desvenlafaxine on memory deficit in a neuroendocrine model of depression. Naunyn-Schmiedeberg's Archives of Pharmacology 391:8, pages 803-817.
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Sarah E. Fiedler, Vijayshree Yadav, Amelia R. Kerns, Catherine Tsang, Sheila Markwardt, Edward Kim, Rebecca Spain, Dennis Bourdette & Sonemany Salinthone. (2017) Lipoic Acid Stimulates cAMP Production in Healthy Control and Secondary Progressive MS Subjects. Molecular Neurobiology 55:7, pages 6037-6049.
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Mark McCarty. (2017) Supplementation with Phycocyanobilin, Citrulline, Taurine, and Supranutritional Doses of Folic Acid and Biotin—Potential for Preventing or Slowing the Progression of Diabetic Complications. Healthcare 5:1, pages 15.
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Ahmet Ali Tuncer, Mehmet Fatih Bozkurt, Tulay Koken, Nurhan Dogan, Mine Kanat Pektaş & Didem Baskin Embleton. (2016) The Protective Effects of Alpha-Lipoic Acid and Coenzyme Q 10 Combination on Ovarian Ischemia-Reperfusion Injury: An Experimental Study . Advances in Medicine 2016, pages 1-8.
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Ryota Uchida, Hinako Okamoto, Naoko Ikuta, Keiji Terao & Takashi Hirota. (2015) Enantioselective Pharmacokinetics of α-Lipoic Acid in Rats. International Journal of Molecular Sciences 16:9, pages 22781-22794.
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Ivana Damnjanović, Dušica Stojanović, Gordana Kocić, Stevo Najman, Sanja Stojanović & Srđan Pesić. (2014) Pharmacotherapeutic aspects of the application of Alpha-lipoic acid as an antioxidant. Hrana i ishrana 55:2, pages 48-53.
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Enantiomer-selective pharmacokinetics, oral bioavailability, and sex effects of various alpha-lipoic acid dosage forms

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Enantiomer-selective pharmacokinetics, oral bioavailability, and sex effects of various alpha-lipoic acid dosage forms

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