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Original Research

Therapeutic effect of protease-activated receptor 2 agonist SLIGRL-NH₂ on loperamide-induced Sprague-Dawley rat constipation model and the related mechanism

Yonggang Zhang1 Department of Colorectal Surgery, The First People’s Hospital of Lianyungang, Lianyungang 222002, China

Tingrui Ge1 Department of Colorectal Surgery, The First People’s Hospital of Lianyungang, Lianyungang 222002, China

Ping Xiang1 Department of Colorectal Surgery, The First People’s Hospital of Lianyungang, Lianyungang 222002, China

Haibing Mao1 Department of Colorectal Surgery, The First People’s Hospital of Lianyungang, Lianyungang 222002, China

Shumin Tang1 Department of Colorectal Surgery, The First People’s Hospital of Lianyungang, Lianyungang 222002, China

Aimin Li2 Department of Neurosurgery, The First People’s Hospital of Lianyungang, Lianyungang 222002, China

Lin Lin3 Department of Gastroenterology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Yinting Wei4 Department of Gastroenterology, Lianyungang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Lianyungang 222000, China, [email protected]Correspondence[email protected]

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Pages 2403-2411 | Published online: 01 Aug 2018

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Yu Zhan, Yong Wen, Liang-liang Zhang, Xu-long Shen, Xiao-hui Chen, Xiao-hai Wu & Xue-gui Tang. (2021) Paeoniflorin Improved Constipation in the Loperamide-Induced Rat Model via TGR5/TRPA1 Signaling-Mediated 5-Hydroxytryptamine Secretion. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-19.
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Ji Won Park, Ji Eun Kim, Yun Ju Choi, Mi Ju Kang, Hyeon Jun Choi, Su Ji Bae, Jin Tae Hong, Ho Lee & Dae Youn Hwang. (2020) Deficiency of complement component 3 may be linked to the development of constipation in FVB/N‐C3 em1Hlee /Korl mice . The FASEB Journal 35:1.
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Carlotta Lambertini, Augusta Zannoni, Noemi Romagnoli, Cristiano Bombardi, Maria Morini, Francesco Dondi, Chiara Bernardini, Monica Forni, Riccardo Rinnovati & Alessandro Spadari. (2020) Expression of Proteinase-Activated Receptor 2 During Colon Volvulus in the Horse. Frontiers in Veterinary Science 7.
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Anastasia Mentessidou, Anastasia Livani, George Chrousos & Petros Mirilas. (2020) Ileocecal Valve Removal Reverses the Constipating Effects of Loperamide in Rats. Journal of Surgical Research 255, pages 371-377.
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Wan-Jun Ju, Ze-kuo Zhao, Shao-Li Chen, Dan-dan Zhou, Wen-Ning Yang, Xiao-Ping Wen & Guang-Li Du. (2020) Buzhongyiqi Decoction Protects Against Loperamide-Induced Constipation by Regulating the Arachidonic Acid Pathway in Rats. Frontiers in Pharmacology 11.
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Therapeutic effect of protease-activated receptor 2 agonist SLIGRL-NH₂ on loperamide-induced Sprague-Dawley rat constipation model and the related mechanism

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Therapeutic effect of protease-activated receptor 2 agonist SLIGRL-NH2 on loperamide-induced Sprague-Dawley rat constipation model and the related mechanism

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Therapeutic effect of protease-activated receptor 2 agonist SLIGRL-NH₂ on loperamide-induced Sprague-Dawley rat constipation model and the related mechanism