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Drug Design, Development and Therapy Volume 12, 2018 - Issue
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Review

Pharmacological mechanism of roflumilast in the treatment of asthma–COPD overlap

Xiaoli Zhang1 Department of Respiratory Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China, [email protected], [email protected]
,
Yuqing Chen1 Department of Respiratory Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China, [email protected], [email protected]
,
Liyu Fan1 Department of Respiratory Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China, [email protected], [email protected]
,
Jiaqi Ye1 Department of Respiratory Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China, [email protected], [email protected]
,
Junsheng Fan2 Department of Respiratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, China
,
Xinjie Xu1 Department of Respiratory Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China, [email protected], [email protected]
,
Danming You3 Department of Respiratory Medicine, Nangfang Hospital of Southern Medical University, Guangzhou, China
,
Sihan Liu3 Department of Respiratory Medicine, Nangfang Hospital of Southern Medical University, Guangzhou, China
,
Xin Chen1 Department of Respiratory Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China, [email protected], [email protected]Correspondence[email protected]
&
Peng Luo1 Department of Respiratory Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China, [email protected], [email protected]Correspondence[email protected]
 show all
Pages 2371-2379 | Published online: 01 Aug 2018

Citations (19)

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Timothy E. Albertson, Janelle V. Pugashetti, Florence Chau-Etchepare, James A. Chenoweth & Susan Murin. (2020) Pharmacotherapeutic management of asthma in the elderly patient. Expert Opinion on Pharmacotherapy 21:16, pages 1991-2010.
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Timothy E. Albertson, James A. Chenoweth, Skyler J. Pearson & Susan Murin. (2020) The pharmacological management of asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS). Expert Opinion on Pharmacotherapy 21:2, pages 213-231.
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Articles from other publishers (17)

Walyson Coelho Costa, Vinícius Amorim Beltrami, Gabriel Henrique Campolina-Silva, Celso Martins Queiroz-Junior, Rodrigo M. Florentino, Jéssica Rayssa Machado, Débora Gonzaga Martins, William Antonio Gonçalves, Lívia Corrêa Barroso, Katia Michelle Freitas, Fernando Pedro de Souza-Neto, Franciel Batista Félix, Rafaela Fernandes da Silva, Cleida Aparecida Oliveira, Niels Olsen Saraiva Câmara, Milene Alvarenga Rachid, Mauro Martins Teixeira, Barbara Maximino Rezende & Vanessa Pinho. (2023) Therapeutic treatment with phosphodiesterase-4 inhibitors alleviates kidney injury and renal fibrosis by increasing MMP-9 in a doxorubicin-induced nephrotoxicity mouse model. International Immunopharmacology 115, pages 109583.
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Ahlam Elmasry, Wafaa A. Aboukamar, Heba Hany & Manar S. Elmehankar. (2022) The immunomodulatory effects of roflumilast on tachyzoite-bradyzoite transition in a murine model of Toxoplasma gondii. International Immunopharmacology 113, pages 109348.
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Suh-Young Lee, Hyun-Seung Lee & Heung-Woo Park. (2022) Transcriptome analysis of sputum cells reveals two distinct molecular phenotypes of “asthma and chronic obstructive pulmonary disease overlap” in the elderly. European Journal of Medical Research 27:1.
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Nicola A. Hanania & Marc Miravitlles. (2022) Pharmacologic Management Strategies of Asthma-Chronic Obstructive Pulmonary Disease Overlap. Immunology and Allergy Clinics of North America 42:3, pages 657-669.
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Dennis Williams. (2020) The Role of the Pharmacist in Optimizing Outcomes With Roflumilast, a PDE4 Inhibitor for the Treatment of COPD. Journal of Pharmacy Practice 35:3, pages 445-454.
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Akira Yamasaki, Ryota Okazaki & Tomoya Harada. (2022) Neutrophils and Asthma. Diagnostics 12:5, pages 1175.
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Theerasuk Kawamatawong. (2021) Phosphodiesterase-4 Inhibitors for Non-COPD Respiratory Diseases. Frontiers in Pharmacology 12.
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Ruby E. Dawson, Brendan J. Jenkins & Mohamed I. Saad. (2021) IL-6 family cytokines in respiratory health and disease. Cytokine 143, pages 155520.
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Rachana Mandru, Christine Y. Zhou, Rachel Pauley & Robert M. Burkes. (2021) Considerations for and Mechanisms of Adjunct Therapy in COPD. Journal of Clinical Medicine 10:6, pages 1225.
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Sugin Lal Jabaris S & Ranju V. (2021) Scope of adjuvant therapy using roflumilast, a PDE-4 inhibitor against COVID-19. Pulmonary Pharmacology & Therapeutics 66, pages 101978.
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Zhongmei Zheng, Bangrong Cao, Yu Hu, Liang Xie, Ling Gu, Fang Shi & Hanmin Liu. (2021) Spatiotemporal Changes in the Gene Expression Spectrum of the β2 Adrenergic Receptor Signaling Pathway in the Lungs of Rhesus Monkeys. Lung 199:1, pages 73-82.
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Jingtong Zhao, Lian Duan, Renxiang Wang, Yi Liu & Jinlan Jiang. (2020) Roflumilast prevents lymphotoxin α (TNF-β)-induced inflammation activation and degradation of type 2 collagen in chondrocytes. Inflammation Research 69:12, pages 1191-1199.
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Chirag A. Shah. (2020) Can roflumilast become steroid-sparing alternative in the treatment of COVID-19?. Medical Hypotheses 144, pages 110246.
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Shradha Bodkhe, Mayuri Nikam, Atul P. Sherje, Tabassum Khan, Vasanti Suvarna & Kavit Patel. (2020) Current insights on clinical efficacy of roflumilast for treatment of COPD, asthma and ACOS. International Immunopharmacology 88, pages 106906.
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Viera Janosova, Vladimir Calkovsky, Heiko Pedan, Estera Behanova, Andrej Hajtman & Andrea Calkovska. (2020) Phosphodiesterase 4 Inhibitors in Allergic Rhinitis/Rhinosinusitis. Frontiers in Pharmacology 11.
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Simeng Chu, Wenjuan Liu, Yujie Lu, Menglin Yan, Yingying Guo, Nianwei Chang, Min Jiang & Gang Bai. (2020) Sinigrin Enhanced Antiasthmatic Effects of Beta Adrenergic Receptors Agonists by Regulating cAMP-Mediated Pathways. Frontiers in Pharmacology 11.
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Feng Chen, Fang Huang & Fei Zhan. (2019) Correlation between serum transforming growth factor β1, interleukin‑6 and neonatal respiratory distress syndrome. Experimental and Therapeutic Medicine.
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