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Drug Design, Development and Therapy Volume 12, 2018 - Issue
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Original Research

No pharmacokinetic interactions between candesartan and amlodipine following multiple oral administrations in healthy subjects

Jung-Ryul Kim1 Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, Republic of Korea, [email protected];2 Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Republic of Korea
,
Seokuee Kim1 Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, Republic of Korea, [email protected]
,
Wooseong Huh1 Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, Republic of Korea, [email protected];3 Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
&
Jae-Wook Ko1 Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, Republic of Korea, [email protected]Correspondence[email protected]
Pages 2475-2483 | Published online: 10 Aug 2018

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Hyungsub Kim, Shi Hyang Lee, Jina Jung, Sunghee Hong & Hyeong-Seok Lim. (2022) Pharmacokinetic Drug Interaction Between Amlodipine and Tadalafil: An Open-Label, Randomized, Multiple-Dose Crossover Study in Healthy Male Volunteers. Drug Design, Development and Therapy 16, pages 425-433.
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Articles from other publishers (9)

Jae Hoon Kim, Ji Hye Song, MinYoung Kim, Jang Hee Hong, Jung Sunwoo & Jin-Gyu Jung. (2024) Pharmacokinetic Comparison of a Fixed-Dose Combination of Candesartan Cilexetil/Amlodipine/Atorvastatin Versus Co-administration of Individual Formulations in Healthy Participants. Advances in Therapy 41:7, pages 2808-2825.
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Meiling Han, Yingxia He, Jun Liang, Fang Yao, Pan Lu, Hegui Yan, Jie Wang, Yafang Xie, Xiuwen Li, Qiangwei Liu, Yang Liu, Baodong Yuan & Ming Zhou. (2024) Pharmacokinetics and bioequivalence study of candesartan cilexetil tablet in Chinese volunteers under fasting condition: an open-label, randomized-sequence, 2-period crossover study. Translational and Clinical Pharmacology 32:2, pages 107.
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Lingfeng Guo, Xinyu Zhu, Lei Zhang & Yichao Xu. (2023) Physiologically based pharmacokinetic modeling of candesartan to predict the exposure in hepatic and renal impairment and elderly populations. Therapeutic Advances in Drug Safety 14.
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Roman Tremmel, Anne T. Nies, Barbara A. C. van Eijck, Niklas Handin, Mathias Haag, Stefan Winter, Florian A. Büttner, Charlotte Kölz, Franziska Klein, Pascale Mazzola, Ute Hofmann, Kathrin Klein, Per Hoffmann, Markus M. Nöthen, Fabienne Z. Gaugaz, Per Artursson, Matthias Schwab & Elke Schaeffeler. (2022) Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation. International Journal of Molecular Sciences 23:13, pages 7468.
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Hyo-jeong Ryu, Hyun-ki Moon, Junho Lee, Gi-hyeok Yang, Sung-yoon Yang, Hwi-yeol Yun, Jung-woo Chae & Won-ho Kang. (2021) Evaluation for Potential Drug–Drug Interaction of MT921 Using In Vitro Studies and Physiologically–Based Pharmacokinetic Models. Pharmaceuticals 14:7, pages 654.
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Kristina Gundlach, Katharina Wolf, Isam Salem, Olaf Randerath & Dan Seiler. (2020) Safety of Candesartan, Amlodipine, and Atorvastatin in Combination: Interaction Study in Healthy Subjects. Clinical Pharmacology in Drug Development 10:2, pages 190-197.
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Eline H. GroenlandMonique E.A.M. van KleefMichiel L. BotsFrank L.J. Visseren, Kim C.M. van der ElstWilko Spiering. (2021) Plasma Trough Concentrations of Antihypertensive Drugs for the Assessment of Treatment Adherence. Hypertension 77:1, pages 85-93.
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Hae Won Lee, Woo Youl Kang, Wookjae Jung, Mi-Ri Gwon, Dong Heon YangEun Hee KimKyunghee ChoYoung-Ran Yoon & Sook Jin Seong. (2020) Pharmacokinetics and bioequivalence of fixed-dose combination of candesartan cilexetil/amlodipine besylate (16/10 mg) versus coadministration of individual formulations in healthy subjects. Translational and Clinical Pharmacology 28:2, pages 92.
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Qi‐Fang Huang, Chang‐Sheng Sheng, Yan Li, Yu Dou, Mei‐Sheng Zheng, Zhi‐Ming Zhu & Ji‐Guang Wang. (2019) A randomized controlled trial on the blood pressure–lowering effect of amlodipine and nifedipine‐GITS in sustained hypertension. The Journal of Clinical Hypertension 21:5, pages 648-657.
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