258
Views
61
CrossRef citations to date
0
Altmetric
Review

Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review

&
Pages 3181-3197 | Published online: 25 Sep 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Ibrahim Turan, Selim Demir, Serap Ozer Yaman, Deniz Canbolat, Ahmet Mentese & Yuksel Aliyazicioglu. (2022) An Investigation of the Antiproliferative Effect of Rhododendron luteum Extract on Cervical Cancer (HeLa) Cells via Nrf2 Signaling Pathway. Nutrition and Cancer 74:5, pages 1882-1893.
Read now
Melford Chuka Egbujor, Sarmistha Saha, Brigitta Buttari, Elisabetta Profumo & Luciano Saso. (2021) Activation of Nrf2 signaling pathway by natural and synthetic chalcones: a therapeutic road map for oxidative stress. Expert Review of Clinical Pharmacology 14:4, pages 465-480.
Read now

Articles from other publishers (59)

Yao Xiang, Xiaohua Song & Dingxin Long. (2024) Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases. Archives of Toxicology.
Crossref
Christophe Glorieux, Cinthya Enríquez, Constanza González, Gabriela Aguirre-Martínez & Pedro Buc Calderon. (2024) The Multifaceted Roles of NRF2 in Cancer: Friend or Foe?. Antioxidants 13:1, pages 70.
Crossref
K. M. Andrie, D. R. Palmer, O. Wahl, S. Bork, M. Campbell, M. A. Walsh, J. Sanford, R. V. Musci, Karyn L. Hamilton, Kelly S. Santangelo & Christian M. Puttlitz. (2023) Treatment with PB125® Increases Femoral Long Bone Strength in 15-Month-Old Female Hartley Guinea Pigs. Annals of Biomedical Engineering.
Crossref
Yongmei Gao, Li Wan, Mengyan Li, Bo Wang & Yuqing Ma. (2023) NRF2/HO-1 axis, BIRC5, and TP53 expression in ESCC and its correlation with clinical pathological characteristics and prognosis. The International Journal of Biological Markers 38:3-4, pages 174-184.
Crossref
Mohammad Yasin Zamanian, Afsaneh Soltani, Zahra Khodarahmi, Ameer A. Alameri, Athemar M. R. Alwan, Andrés Alexis Ramírez‐Coronel, Rasha Fadhel Obaid, Munther Abosaooda, Mahsa Heidari, Maryam Golmohammadi & Mahdieh Anoush. (2023) Targeting Nrf2 signaling pathway by quercetin in the prevention and treatment of neurological disorders: An overview and update on new developments. Fundamental & Clinical Pharmacology 37:6, pages 1050-1064.
Crossref
Jiale Li, Chang Xu & Qiang Liu. (2023) Roles of NRF2 in DNA damage repair. Cellular Oncology 46:6, pages 1577-1593.
Crossref
Qin Fang, Yang Bai, Shuiqing Hu, Jie Ding, Lei Liu, Meiyan Dai, Jie Qiu, Lujin Wu, Xiaoquan Rao & Yan Wang. (2023) Unleashing the Potential of Nrf2: A Novel Therapeutic Target for Pulmonary Vascular Remodeling. Antioxidants 12:11, pages 1978.
Crossref
Marialucia GalloriniSimone Carradori, Emiliano Panieri, Matej SovaLuciano Saso. (2023) Modulation of NRF2: Biological Dualism in Cancer, Targets and Possible Therapeutic Applications. Antioxidants & Redox Signaling.
Crossref
Abdulrahim A. Alzain, Rua M. Mukhtar, Nihal Abdelmoniem, Tagyedeen H. Shoaib, Wadah Osman, Marwa Alsulaimany, Ahmed K. B. Aljohani, Sara A. Almadani, Baiaan H. Alsaadi, Maryam M. Althubyani, Shaimaa G. A. Mohamed, Gamal A. Mohamed & Sabrin R. M. Ibrahim. (2023) Modulation of NRF2/KEAP1-Mediated Oxidative Stress for Cancer Treatment by Natural Products Using Pharmacophore-Based Screening, Molecular Docking, and Molecular Dynamics Studies. Molecules 28:16, pages 6003.
Crossref
Darinka Gjorgieva Ackova, Viktorija Maksimova, Katarina Smilkov, Brigitta Buttari, Marzia Arese & Luciano Saso. (2023) Alkaloids as Natural NRF2 Inhibitors: Chemoprevention and Cytotoxic Action in Cancer. Pharmaceuticals 16:6, pages 850.
Crossref
Irina Tyuryaeva & Olga Lyublinskaya. (2023) Expected and Unexpected Effects of Pharmacological Antioxidants. International Journal of Molecular Sciences 24:11, pages 9303.
Crossref
Javad Sharifi-Rad, Veronique Seidel, Michalak Izabela, Margalida Monserrat-Mequida, Antoni Sureda, Valeska Ormazabal, Felipe A. Zuniga, Shivaprasad Shetty Mangalpady, Raffaele Pezzani, Alibek Ydyrys, Gulmira Tussupbekova, Miquel Martorell, Daniela Calina & William C. Cho. (2023) Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy. Cell Communication and Signaling 21:1.
Crossref
Changyong Lee, Sik Yoon & Jeon-Ok Moon. (2023) Kaempferol Suppresses Carbon Tetrachloride-Induced Liver Damage in Rats via the MAPKs/NF-κB and AMPK/Nrf2 Signaling Pathways. International Journal of Molecular Sciences 24:8, pages 6900.
Crossref
Jiaqi Lan, Yujun Zhou, Hongyue Wang, Jingshu Tang, Yuying Kang, Peishen Wang, Xuebin Liu & Ying Peng. (2023) Protective effect of human umbilical cord mesenchymal stem cell derived conditioned medium in a mutant TDP-43 induced motoneuron-like cellular model of ALS. Brain Research Bulletin 193, pages 106-116.
Crossref
Farhad Pouremamali, Amir Pouremamali, Mehdi Dadashpour, Narges Soozangar & Farhad Jeddi. (2022) An update of Nrf2 activators and inhibitors in cancer prevention/promotion. Cell Communication and Signaling 20:1.
Crossref
Fengyu Ma, Shangdie Luo, Chunting Lu, Xinrong Jiang, Kexiao Chen, Jianwen Deng, Shuyuan Ma & Zejian Li. (2022) The role of Nrf2 in periodontal disease by regulating lipid peroxidation, inflammation and apoptosis. Frontiers in Endocrinology 13.
Crossref
Rohini Srivastava, Raquel Fernández-Ginés, José Antonio Encinar, Antonio Cuadrado & Geoff Wells. (2022) The current status and future prospects for therapeutic targeting of KEAP1-NRF2 and β-TrCP-NRF2 interactions in cancer chemoresistance. Free Radical Biology and Medicine 192, pages 246-260.
Crossref
Tianming Zhao, Zihan Yu, Lei Zhou, Xiaoyu Wang, Yangyang Hui, Lihong Mao, Xiaofei Fan, Bangmao Wang, Xingliang Zhao & Chao Sun. (2022) Regulating Nrf2-GPx4 axis by bicyclol can prevent ferroptosis in carbon tetrachloride-induced acute liver injury in mice. Cell Death Discovery 8:1.
Crossref
Shubham Upadhayay, Sidharth Mehan, Aradhana Prajapati, Pranshul Sethi, Manisha Suri, Ayat Zawawi, Majed N. Almashjary & Shams Tabrez. (2022) Nrf2/HO-1 Signaling Stimulation through Acetyl-11-Keto-Beta-Boswellic Acid (AKBA) Provides Neuroprotection in Ethidium Bromide-Induced Experimental Model of Multiple Sclerosis. Genes 13:8, pages 1324.
Crossref
Sibel Suzen, Paolo Tucci, Elisabetta Profumo, Brigitta Buttari & Luciano Saso. (2022) A Pivotal Role of Nrf2 in Neurodegenerative Disorders: A New Way for Therapeutic Strategies. Pharmaceuticals 15:6, pages 692.
Crossref
Koraljka Gall Trošelj, Marko Tomljanović, Morana Jaganjac, Tanja Matijević Glavan, Ana Čipak Gašparović, Lidija Milković, Suzana Borović Šunjić, Brigitta Buttari, Elisabetta Profumo, Sarmistha Saha, Luciano Saso & Neven Žarković. (2022) Oxidative Stress and Cancer Heterogeneity Orchestrate NRF2 Roles Relevant for Therapy Response. Molecules 27:5, pages 1468.
Crossref
Hesham R. El-Seedi, Nehal Eid, Aida A. Abd El-Wahed, Mostafa E. Rateb, Hanan S. Afifi, Ahmed F. Algethami, Chao Zhao, Yahya Al Naggar, Sultan M. Alsharif, Haroon Elrasheid Tahir, Baojun Xu, Kai Wang & Shaden A. M. Khalifa. (2022) Honey Bee Products: Preclinical and Clinical Studies of Their Anti-inflammatory and Immunomodulatory Properties. Frontiers in Nutrition 8.
Crossref
Daniela LAUDISIO, Bianca CASTELLUCCI, Luigi BARREA, Gabriella PUGLIESE, Silvia SAVASTANO, Annamaria COLAO & Giovanna MUSCOGIURI. (2022) Mediterranean diet and breast cancer risk: a narrative review. Minerva Endocrinology 46:4.
Crossref
Nelly M. Dabbour, Ahmed M. Salama, Thoria Donia, Radwa T. Al-Deeb, Abdullah M. Abd Elghane, Karima H. Badry & Samah A. Loutfy. (2022) Managing GSH elevation and hypoxia to overcome resistance of cancer therapies using functionalized nanocarriers. Journal of Drug Delivery Science and Technology 67, pages 103022.
Crossref
Nina Katarina Grilc, Matej Sova & Julijana Kristl. (2021) Drug Delivery Strategies for Curcumin and Other Natural Nrf2 Modulators of Oxidative Stress-Related Diseases. Pharmaceutics 13:12, pages 2137.
Crossref
Md Afjalus Siraj, Md. Arman Islam, Md. Abdullah Al Fahad, Habiba Rahman Kheya, Jianbo Xiao & Jesus Simal-Gandara. (2021) Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update. Applied Sciences 11:22, pages 10806.
Crossref
Zahra Memariani, Syed Qamar Abbas, Syed Shams ul Hassan, Amirhossein Ahmadi & Aroona Chabra. (2021) Naringin and naringenin as anticancer agents and adjuvants in cancer combination therapy: Efficacy and molecular mechanisms of action, a comprehensive narrative review. Pharmacological Research 171, pages 105264.
Crossref
Wolfram C.M. Dempke & Martin Reck. (2021) KEAP1/NRF2 (NFE2L2) mutations in NSCLC – Fuel for a superresistant phenotype?. Lung Cancer 159, pages 10-17.
Crossref
Marcelo Farina, Leonardo Eugênio Vieira, Brigitta Buttari, Elisabetta Profumo & Luciano Saso. (2021) The Nrf2 Pathway in Ischemic Stroke: A Review. Molecules 26:16, pages 5001.
Crossref
Kyung-Soo Chun, Pawan Kumar Raut, Do-Hee Kim & Young-Joon Surh. (2021) Role of chemopreventive phytochemicals in NRF2-mediated redox homeostasis in humans. Free Radical Biology and Medicine 172, pages 699-715.
Crossref
Bingbing Dai, Jithesh J. Augustine, Ya’an Kang, David Roife, Xinqun Li, Jenying Deng, Lin Tan, Leona A. Rusling, John N. Weinstein, Philip L. Lorenzi, Michael P. Kim & Jason B. Fleming. (2021) Compound NSC84167 selectively targets NRF2-activated pancreatic cancer by inhibiting asparagine synthesis pathway. Cell Death & Disease 12:7.
Crossref
Serhii Holota. (2021) Synthesis of novel pyrazoline-thiazolidin-4-one hybrids and evaluation their biological activity. Ukrainica Bioorganica Acta 16:1, pages 18-24.
Crossref
Jonathan Muri & Manfred Kopf. (2020) Redox regulation of immunometabolism. Nature Reviews Immunology 21:6, pages 363-381.
Crossref
Bercis Imge Ucar, Gulberk Ucar, Sarmistha Saha, Brigitta Buttari, Elisabetta Profumo & Luciano Saso. (2021) Pharmacological Protection against Ischemia-Reperfusion Injury by Regulating the Nrf2-Keap1-ARE Signaling Pathway. Antioxidants 10:6, pages 823.
Crossref
Dunfa Peng, Alexander Zaika, Jianwen Que & Wael El-Rifai. (2021) The antioxidant response in Barrett's tumorigenesis: A double-edged sword. Redox Biology 41, pages 101894.
Crossref
Zerrin Sezgin-Bayindir, Sonia Losada-Barreiro, Carlos Bravo-Díaz, Matej Sova, Julijana Kristl & Luciano Saso. (2021) Nanotechnology-Based Drug Delivery to Improve the Therapeutic Benefits of NRF2 Modulators in Cancer Therapy. Antioxidants 10:5, pages 685.
Crossref
Pelin Telkoparan-Akillilar, Emiliano Panieri, Dilek Cevik, Sibel Suzen & Luciano Saso. (2021) Therapeutic Targeting of the NRF2 Signaling Pathway in Cancer. Molecules 26:5, pages 1417.
Crossref
Young‐Joon Surh. (2021) Nrf2 paradox: Can cancer patients eat broccoli?. Food Frontiers 2:1, pages 25-28.
Crossref
S.I Ojeaburu & K Oriakhi. (2021) Hepatoprotective, antioxidant and, anti-inflammatory potentials of gallic acid in carbon tetrachloride-induced hepatic damage in Wistar rats. Toxicology Reports 8, pages 177-185.
Crossref
Sajan George & Heidi Abrahamse. (2020) Redox Potential of Antioxidants in Cancer Progression and Prevention. Antioxidants 9:11, pages 1156.
Crossref
Sandra Senkała, Jan Grzegorz Małecki, Marharyta Vasylieva, Aleksandra Łabuz, Katarzyna Nosek, Katarzyna Piwowarczyk, Jarosław Czyż, Ewa Schab-Balcerzak, Henryk Janeczek & Mateusz Korzec. (2020) Hydrolysis of Schiff bases with phenyl-ethynyl-phenyl system: The importance for biological and physicochemical studies. Journal of Photochemistry and Photobiology B: Biology 212, pages 112020.
Crossref
Leanne Ambrosio, Monica Argenziano, Marie Angèle Cucci, Margherita Grattarola, Inge A.M. de Graaf, Chiara Dianzani, Giuseppina Barrera, Javier Sánchez Nieves, Rafael Gomez, Roberta Cavalli & Stefania Pizzimenti. (2020) Carbosilane Dendrimers Loaded with siRNA Targeting Nrf2 as a Tool to Overcome Cisplatin Chemoresistance in Bladder Cancer Cells. Antioxidants 9:10, pages 993.
Crossref
Xiaofei Fan, Lin Lin, Binxin Cui, Tianming Zhao, Lihong Mao, Yan Song, Xiaoyu Wang, Hongjuan Feng, Yu Qingxiang, Jie Zhang, Kui Jiang, Xiaocang Cao, Bangmao Wang & Chao Sun. (2020) Therapeutic potential of genipin in various acute liver injury, fulminant hepatitis, NAFLD and other non-cancer liver diseases: More friend than foe. Pharmacological Research 159, pages 104945.
Crossref
Simranbir Kaur & Ludmil T. Benov. (2020) Methylene blue induces the soxRS regulon of Escherichia coli. Chemico-Biological Interactions 329, pages 109222.
Crossref
Jasmina Djedjibegovic, Aleksandra Marjanovic, Emiliano Panieri & Luciano Saso. (2020) Ellagic Acid-Derived Urolithins as Modulators of Oxidative Stress. Oxidative Medicine and Cellular Longevity 2020, pages 1-15.
Crossref
Donna D. Zhang & Eli Chapman. (2020) The role of natural products in revealing NRF2 function. Natural Product Reports 37:6, pages 797-826.
Crossref
T. G. Borovskaya, A. V. Vychuzhanina, V. A. Grigor’eva, O. V. Kollantay, V. E. Goldberg & A. M. Dygai. (2020) Evaluation of the Effect of p-Tyrosol on the Level of DNA Damage in the DNA Comet Assay In Vivo. Bulletin of Experimental Biology and Medicine 169:2, pages 233-236.
Crossref
Daniel Pouliquen, Alice Boissard, Olivier Coqueret & Catherine Guette. (2020) Biomarkers of tumor invasiveness in proteomics (Review). International Journal of Oncology 57:2, pages 409-432.
Crossref
Md Ashraf-Uz-Zaman, Aditya Bhalerao, Constantinos M. Mikelis, Luca Cucullo & Nadezhda A. German. (2020) Assessing the Current State of Lung Cancer Chemoprevention: A Comprehensive Overview. Cancers 12:5, pages 1265.
Crossref
Vashisht Madabhushi, Job Tharappel, Satya Alluri, Crystal Totten & John Scott Roth. (2020) Hernia Repair Strength Enhanced With Antioxidants. Journal of Surgical Research 247, pages 144-149.
Crossref
Emiliano Panieri, Aleksandra Buha, Pelin Telkoparan-Akillilar, Dilek Cevik, Demetrios Kouretas, Aristidis Veskoukis, Zoi Skaperda, Aristidis Tsatsakis, David Wallace, Sibel Suzen & Luciano Saso. (2020) Potential Applications of NRF2 Modulators in Cancer Therapy. Antioxidants 9:3, pages 193.
Crossref
Lourdes Alvarez-Arellano, Nadia González-García, Marcela Salazar-García & Juan Carlos Corona. (2020) Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder. Antioxidants 9:2, pages 176.
Crossref
Christian Bailly. (2019) Potential use of edaravone to reduce specific side effects of chemo-, radio- and immuno-therapy of cancers. International Immunopharmacology 77, pages 105967.
Crossref
Yanping Zhou, Zhongliang Jiang, Haiying Lu, Zhuyu Xu, Rongsheng Tong, Jianyou Shi & Guiqing Jia. (2019) Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway. Chemistry & Biodiversity 16:11.
Crossref
Seoyeon Kyung, Joo Weon Lim & Hyeyoung Kim. (2019) α-Lipoic Acid Inhibits IL-8 Expression by Activating Nrf2 Signaling in Helicobacter pylori-infected Gastric Epithelial Cells. Nutrients 11:10, pages 2524.
Crossref
Walter H. Moos, Douglas V. Faller, Ioannis P. Glavas, David N. Harpp, Iphigenia Kanara, Carl A. Pinkert, Whitney R. Powers, Konstantina Sampani, Kosta Steliou, Demetrios G. Vavvas, Krishna Kodukula & Robert J. Zamboni. (2019) Epigenetic treatment of dermatologic disorders. Drug Development Research 80:6, pages 702-713.
Crossref
Jastrząb, Gęgotek & Skrzydlewska. (2019) Cannabidiol Regulates the Expression of Keratinocyte Proteins Involved in the Inflammation Process through Transcriptional Regulation. Cells 8:8, pages 827.
Crossref
Doumet Georges Helou, Stefan F. Martin, Marc Pallardy, Sylvie Chollet-Martin & Saadia Kerdine-Römer. (2019) Nrf2 Involvement in Chemical-Induced Skin Innate Immunity. Frontiers in Immunology 10.
Crossref
Pelin Telkoparan-Akillilar, Sibel Suzen & Luciano Saso. (2019) Pharmacological Applications of Nrf2 Inhibitors as Potential Antineoplastic Drugs. International Journal of Molecular Sciences 20:8, pages 2025.
Crossref