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Drug Design, Development and Therapy Volume 13, 2019 - Issue
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Original Research

Effects of acarbose and metformin on the inflammatory state in newly diagnosed type 2 diabetes patients: a one-year randomized clinical study

Dan Mo1 Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu610041, People’s Republic of China
,
Songfang Liu1 Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu610041, People’s Republic of China
,
Hong Ma1 Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu610041, People’s Republic of China
,
Haoming Tian1 Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu610041, People’s Republic of China
,
Honglin Yu2 Laboratory of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu610041, People’s Republic of China
,
Xiangxun Zhang2 Laboratory of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu610041, People’s Republic of China
,
Nanwei Tong2 Laboratory of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu610041, People’s Republic of China
,
Jiayu Liao3 Department of Bioengineering, Bourns College of Engineering, University of California, Riverside, CA92521, USA;4 West China Hospital-California Multiomics Research Center, Key Laboratory of Transplant Engineering and Immunology, National Health Commission of PRC, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China
&
Yan Ren1 Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu610041, People’s Republic of ChinaCorrespondence[email protected]
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Pages 2769-2776 | Published online: 09 Aug 2019

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Qinghao Meng, Yidong Xu, Ying Li & Yiwen Wang. (2023) Novel studies on Drosophila melanogaster model reveal the roles of JNK-Jak/STAT axis and intestinal microbiota in insulin resistance. Journal of Drug Targeting 31:3, pages 261-268.
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Benjamin Amoani, Samuel A. Sakyi, Richard Mantey, Edwin F. Laing, Richard D. Ephraim, Osei Sarfo-Katanka, Simon Koffie, Ernest Obese & Bright Oppong Afranie. (2021) Increased metformin dosage suppresses pro-inflammatory cytokine levels in systemic circulation and might contribute to its beneficial effects. Journal of Immunoassay and Immunochemistry 42:3, pages 252-264.
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Articles from other publishers (25)

Mohammad Zamani, Mahlagha Nikbaf-Shandiz, Yasaman Aali, Niloufar Rasaei, Mahtab Zarei, Farideh Shiraseb & Omid Asbaghi. (2023) The effects of acarbose treatment on cardiovascular risk factors in impaired glucose tolerance and diabetic patients: a systematic review and dose–response meta-analysis of randomized clinical trials. Frontiers in Nutrition 10.
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Jing Jing, Chang Liu, Wanlin Zhu, Yuesong Pan, Jiyang Jiang, Xueli Cai, Zhe Zhang, Zixiao Li, Yijun Zhou, Xia Meng, Jian Cheng, Yilong Wang, Hao Li, Yong Jiang, Huaguang Zheng, Suying Wang, Haijun Niu, Wei Wen, Perminder S. Sachdev, Tiemin Wei, Tao Liu & Yongjun Wang. (2023) Increased Resting-State Functional Connectivity as a Compensatory Mechanism for Reduced Brain Volume in Prediabetes and Type 2 Diabetes. Diabetes Care 46:4, pages 819-827.
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Ezekiel Musa, Esteban Salazar‐Petres, Afolake Arowolo, Naomi Levitt, Mushi Matjila & Amanda N. Sferruzzi‐Perri. (2023) Obesity and gestational diabetes independently and collectively induce specific effects on placental structure, inflammation and endocrine function in a cohort of South African women. The Journal of Physiology 601:7, pages 1287-1306.
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Edoardo Mannucci, Marco Gallo, Andrea Giaccari, Riccardo Candido, Basilio Pintaudi, Giovanni Targher & Matteo Monami. (2022) Effects of glucose‐lowering agents on cardiovascular and renal outcomes in subjects with type 2 diabetes: An updated meta‐analysis of randomized controlled trials with external adjudication of events. Diabetes, Obesity and Metabolism 25:2, pages 444-453.
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Lily Wink, Richard A. Miller & Gonzalo G. Garcia. (2022) Rapamycin, Acarbose and 17α-estradiol share common mechanisms regulating the MAPK pathways involved in intracellular signaling and inflammation. Immunity & Ageing 19:1.
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Jin Qian & Ying Huang. (2022) Expression of TNF-α and IL-1β in Peripheral Blood of Patients with T2DM Retinopathy. Computational and Mathematical Methods in Medicine 2022, pages 1-7.
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Hend Alfadul, Shaun Sabico & Nasser M. Al-Daghri. (2022) The role of interleukin-1β in type 2 diabetes mellitus: A systematic review and meta-analysis. Frontiers in Endocrinology 13.
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Pavel Weber, Hana Meluzínová & Dana Weberová. (2022) New trends in the approach to the treatment of type 2 diabetes - observations and benefits in the outpatient practice of a diabetologist. Klinická farmakologie a farmacie 35:4, pages 118-123.
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Baiyun Wu, Jiai Yan, Ju Yang, Yanping Xia, Dan Li, Feng Zhang & Hong Cao. (2022) Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota?. Aging and disease 13:4, pages 1005.
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Jinghong Li, Qi Wei, Karen C. McCowen, Wei Xiong, Jiao Liu, Wenlijun Jiang, Robert L. Thomas, Mark Hepokoski, Ming He, John Y. J. Shyy, Atul Malhotra, Nian Xiong & Willis X. Li. (2021) Inpatient use of metformin and acarbose is associated with reduced mortality of COVID‐19 patients with type 2 diabetes mellitus. Endocrinology, Diabetes & Metabolism 5:1.
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Michaele B. Manigrasso, Piul Rabbani, Lander Egaña-Gorroño, Nosirudeen Quadri, Laura FryeBoyan Zhou, Sergey Reverdatto, Lisa S. Ramirez, Stephen DansereauJinhong PanHuilin Li, Vivette D. D’AgatiRavichandran Ramasamy, Robert J. DeVitaAlexander Shekhtman & Ann Marie Schmidt. (2021) Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice. Science Translational Medicine 13:621.
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Marc Foretz, Bruno Guigas & Benoit Viollet. (2021) Données récentes sur le mécanisme d’action de la metformine dans le diabète de type 2. Médecine des Maladies Métaboliques 15:7, pages 648-660.
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Emir M. Muzurović, Snežana Vujošević & Dimitri P. Mikhailidis. (2021) Can We Decrease Epicardial and Pericardial Fat in Patients With Diabetes?. Journal of Cardiovascular Pharmacology and Therapeutics 26:5, pages 415-436.
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Amir Karbalaee-Hasani, Tooka Khadive, Mahsa Eskandari, Shabnam Shahidi, Maryam Mosavi, Zivar Nejadebrahimi, Lida Khalkhali, Amirhossein Sangdari, Davoud Mohammadi, Ali Soltani, Hadi Khodabandehloo, Hossein Hosseini & Mehdi Koushki. (2021) Effect of Metformin on Circulating Levels of Inflammatory Markers in Patients With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Annals of Pharmacotherapy 55:9, pages 1096-1109.
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Alaa M. Hammad, Yasmeen A. Ibrahim, Sawsan I. Khdair, F. Scott Hall, Malek Alfaraj, Yazan Jarrar & Abdulqader Fadhil Abed. (2021) Metformin reduces oxandrolone- induced depression-like behavior in rats via modulating the expression of IL-1β, IL-6, IL-10 and TNF-α. Behavioural Brain Research 414, pages 113475.
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Daniel L. SmithJrJr, Rachael M. Orlandella, David B. Allison & Lyse A. Norian. (2020) Diabetes medications as potential calorie restriction mimetics—a focus on the alpha-glucosidase inhibitor acarbose. GeroScience 43:3, pages 1123-1133.
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Shuai Yuan, Huaping Li, Chen Chen, Feng Wang & Dao Wen Wang. (2021) Association of glycosylated haemoglobin HbA1c levels with outcome in patients with COVID‐19: A Retrospective Study. Journal of Cellular and Molecular Medicine 25:7, pages 3484-3497.
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Abigail R. Anness, Aisha Baldo, David R. Webb, Asma Khalil, Thompson G. Robinson & Hatem A. Mousa. (2021) Effect of metformin on biomarkers of placental- mediated disease: A systematic review and meta-analysis. Placenta 107, pages 51-58.
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Ming-Han Hsieh, Tzu-Yu Kao, Ting-Hui Hsieh, Chun-Chi Kao, Cheng-Yuan Peng, Hsueh-Chou Lai, Po-Heng Chuang & Jung-Ta Kao. (2020) Prognostic roles of diabetes mellitus and hypertension in advanced hepatocellular carcinoma treated with sorafenib. PLOS ONE 15:12, pages e0244293.
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Niki Katsiki & Ele Ferrannini. (2020) Anti-inflammatory properties of antidiabetic drugs: A “promised land” in the COVID-19 era?. Journal of Diabetes and its Complications 34:12, pages 107723.
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Patrick Kwabena Oduro, Jingmei Fang, Lu Niu, Yuhong Li, Lin Li, Xin Zhao & Qilong Wang. (2020) Pharmacological management of vascular endothelial dysfunction in diabetes: TCM and western medicine compared based on biomarkers and biochemical parameters. Pharmacological Research 158, pages 104893.
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Sounak Ghosh, Dongling Luo, Wanbing He, Jie Chen, Xiaoyan Su & Hui Huang. (2020) Diabetes and calcification: The potential role of anti-diabetic drugs on vascular calcification regression. Pharmacological Research 158, pages 104861.
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Filip Gnesin, Anne Cathrine Baun Thuesen, Lise Katrine Aronsen Kähler, Sten Madsbad & Bianca Hemmingsen. (2020) Metformin monotherapy for adults with type 2 diabetes mellitus. Cochrane Database of Systematic Reviews 2020:6.
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Sona Margaryan, Eva Kriegova, Regina Fillerova, Veronika Smotkova Kraiczova & Gayane Manukyan. (2020) Hypomethylation of IL1RN and NFKB1 genes is linked to the dysbalance in IL1β/IL-1Ra axis in female patients with type 2 diabetes mellitus. PLOS ONE 15:5, pages e0233737.
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Alexey Moskalev, Ilia Stambler & Calogero Caruso. (2020) Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience. Aging and disease 11:6, pages 1363.
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