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Drug Design, Development and Therapy Volume 14, 2020 - Issue
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Original Research

Metformin Inhibits Propofol-Induced Apoptosis of Mouse Hippocampal Neurons HT-22 Through Downregulating Cav-1

Jianyun Ge1 Department of Anesthesiology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, People’s Republic of China
,
Yulin Huang2 Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical School of Nanjing University, Nanjing, Jiangsu 210000, People’s Republic of China
,
Yi Zhang3 Department of Neurosurgery, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, People’s Republic of China
,
Lin Liu1 Department of Anesthesiology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, People’s Republic of China
,
Tianyu Gu1 Department of Anesthesiology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, People’s Republic of China
,
Xu Liu1 Department of Anesthesiology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, People’s Republic of China
,
Lei Yao1 Department of Anesthesiology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, People’s Republic of China
,
Mengmeng Cai1 Department of Anesthesiology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, People’s Republic of China
,
Jiafeng Sun1 Department of Anesthesiology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, People’s Republic of China
&
Jie Song1 Department of Anesthesiology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, People’s Republic of ChinaCorrespondence[email protected]
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Pages 1561-1569 | Published online: 21 Apr 2020

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Hayder M. Al-Kuraishy, Ghassan M. Sulaiman, Majid S. Jabir, Hamdoon A. Mohammed, Ali I. Al-Gareeb, Salim Albukhaty, Daniel J. Klionsky & Mosleh M. Abomughaid. (2024) Defective autophagy and autophagy activators in myasthenia gravis: a rare entity and unusual scenario. Autophagy 0:0, pages 1-10.
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Articles from other publishers (9)

Moein Ebrahimi, Ali Dabbagh & Firoozeh Madadi. (2024) Propofol-induced hippocampal Neurotoxicity: A mitochondrial perspective. Brain Research 1831, pages 148841.
Crossref
Xin Wang & Zhenzhen Wan. (2023) Dexmedetomidine alleviates propofol-induced pyroptosis of hippocampal neurons through NLRP3 inflammasome pathway. NeuroReport 34:7, pages 375-384.
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Mahmoud Khaleghi-Mehr, Alireza-Azizzadeh Delshad, Sepideh Shafie-Damavandi & Mehrdad Roghani. (2023) Metformin mitigates amyloid β1-40-induced cognitive decline via attenuation of oxidative/nitrosative stress and neuroinflammation. Metabolic Brain Disease 38:4, pages 1127-1142.
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Gui Cao, Ting Gong, Yue Du, Yicun Wang, Tongtong Ge & Jingyu Liu. (2022) Mechanism of metformin regulation in central nervous system: Progression and future perspectives. Biomedicine & Pharmacotherapy 156, pages 113686.
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Daniela Silva, Ruben Rocha, Ana Salomé Correia, Bárbara Mota, Maria Dulce Madeira, Nuno Vale & Armando Cardoso. (2022) Repurposed Edaravone, Metformin, and Perampanel as a Potential Treatment for Hypoxia–Ischemia Encephalopathy: An In Vitro Study. Biomedicines 10:12, pages 3043.
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Nuojin Li, Tian Zhou & Erkang Fei. (2022) Actions of Metformin in the Brain: A New Perspective of Metformin Treatments in Related Neurological Disorders. International Journal of Molecular Sciences 23:15, pages 8281.
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Yu-Hai Xu, Yuan Luo, Jiang-Bei Cao, Yan-Hong Liu, Yu-Xiang Song, Xiao-Ying Zhang, Qiang Fu, Wei-Dong Mi & Hao Li. (2022) lncRNA BDNF-AS Attenuates Propofol-Induced Apoptosis in HT22 Cells by Modulating the BDNF/TrkB Pathway. Molecular Neurobiology 59:6, pages 3504-3511.
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Tongyin Zhang, Daofei Ji, Junyi Sun, Jiangling Song, Limin Nie & Na Sun. (2021) NPAS4 suppresses propofol-induced neurotoxicity by inhibiting autophagy in hippocampal neuronal cells. Archives of Biochemistry and Biophysics 711, pages 109018.
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Fan Yang, Hai Zhao, Kaiyuan Zhang, Xiuying Wu & Hongtao Liu. (2020) Research progress and treatment strategies for anesthetic neurotoxicity. Brain Research Bulletin 164, pages 37-44.
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