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Drug Design, Development and Therapy Volume 14, 2020 - Issue
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Original Research

Effects of Apatinib on the Pharmacokinetics of Nifedipine and Warfarin in Patients with Advanced Solid Tumors

Yun-Ting Zhu1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
,
Zan Teng2 Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, People’s Republic of China;3 Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, The First Hospital of China Medical University, Shenyang, People’s Republic of China
,
Yi-Fan Zhang1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of ChinaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-9164-8309
ORCID Icon,
Wei Li1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
,
Li-Xia Guo1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
,
Yun-Peng Liu2 Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, People’s Republic of China;3 Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, The First Hospital of China Medical University, Shenyang, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-9645-7990
ORCID Icon,
Xiu-Juan Qu2 Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, People’s Republic of China;3 Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, The First Hospital of China Medical University, Shenyang, People’s Republic of China
,
Quan-Ren Wang4 Department of Clinical Research and Development, Jiangsu Hengrui Medicine Co., Ltd., Shanghai, People’s Republic of China
,
Si-Yuan Mao4 Department of Clinical Research and Development, Jiangsu Hengrui Medicine Co., Ltd., Shanghai, People’s Republic of China
,
Xiao-Yan Chen1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
&
Da-Fang Zhong1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Pages 1963-1970 | Published online: 20 May 2020

Citations (7)

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Ayaka Kojima, Masayuki Nadai, Norie Murayama, Hiroshi Yamazaki & Miki Katoh. (2022) Effects of multi-kinase inhibitors on the activity of cytochrome P450 2J2. Xenobiotica 52:7, pages 669-675.
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Articles from other publishers (6)

Ni-hong Pang, Ren-ai Xu, Lian-guo Chen, Zhe Chen, Guo-xin Hu & Bo-wen Zhang. (2024) Inhibitory effects of the main metabolites of Apatinib on CYP450 isozymes in human and rat liver microsomes. Toxicology in Vitro 95, pages 105739.
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Yuxiang Ma, Qun Chen, Yang Zhang, Jinhui Xue, Qianwen Liu, Yuanyuan Zhao, Yunpeng Yang, Yan Huang, Wenfeng Fang, Zhiguo Hou, Shaorong Li, Jing Wang, Li Zhang & Hongyun Zhao. (2023) Pharmacokinetics, safety, tolerability, and feasibility of apatinib in combination with gefitinib in stage IIIB-IV EGFR-mutated non-squamous NSCLC: a drug-drug interaction study. Cancer Chemotherapy and Pharmacology 92:5, pages 411-418.
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Fengling Wang, Xue Zhang, Yanyan Wang, Yunna Chen, Huiyu Lu, Xiangyun Meng, Xi Ye & Weidong Chen. (2023) Activation/Inactivation of Anticancer Drugs by CYP3A4: Influencing Factors for Personalized Cancer Therapy. Drug Metabolism and Disposition 51:5, pages 543-559.
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Hongrui Liu, Yiqun Yu, Lu Liu, Chunyan Wang, Nan Guo, Xiaojuan Wang, Xiaoqiang Xiang & Bing Han. (2022) Application of physiologically-based pharmacokinetic/pharmacodynamic models to evaluate the interaction between nifedipine and apatinib. Frontiers in Pharmacology 13.
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Hongrui Liu, Yiqun Yu, Nan Guo, Xiaojuan Wang, Bing Han & Xiaoqiang Xiang. (2021) Application of Physiologically Based Pharmacokinetic Modeling to Evaluate the Drug–Drug and Drug–Disease Interactions of Apatinib. Frontiers in Pharmacology 12.
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Fengli Zhang, Yanfen Yin, Wenwen Xu, Zhou Zhou, Xin Sun & Ping Li. (2021) Apatinib combined with Keytruda treatment induces apoptosis of gastric carcinoma cells through CES4/miR‐616‐5p/DUSP2 axis. Basic & Clinical Pharmacology & Toxicology 129:5, pages 345-356.
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