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Drug Design, Development and Therapy Volume 14, 2020 - Issue
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Original Research

Oxymatrine Liposomes for Intervertebral Disc Treatment: Formulation, in vitro and vivo Assessments

Huan Wang1 Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China
,
Yifan Ding1 Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China
,
Wei Zhang2 Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China
,
Kang Wei1 Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China
,
Yaping Pei1 Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China
,
Chenming Zou2 Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China
,
Chong Zhang2 Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China
,
Jiahui Ding2 Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China
,
Huang Fang1 Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of ChinaCorrespondence[email protected]
&
Songwei Tan2 Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2986-8968
ORCID Icon show all
Pages 921-931 | Published online: 28 Feb 2020

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Yunxiang Hu, Rui Yang, Sanmao Liu, Zefeng Song & Hong Wang. (2024) The Emerging Roles of Nanocarrier Drug Delivery System in Treatment of Intervertebral Disc Degeneration-Current Knowledge, Hot Spots, Challenges and Future Perspectives. Drug Design, Development and Therapy 18, pages 1007-1022.
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Chunran Pan, Wenjie Hou, Xiaofeng Deng, Jiawei Liu, Ruimin Chi, Xingru Shang, Tao Xu & Xiaoxia Hao. (2023) The Pivotal Role of Nrf2 Signal Axis in Intervertebral Disc Degeneration. Journal of Inflammation Research 16, pages 5819-5833.
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Dong Liu, Yanjun Chen, Fang Li, Cunwu Chen, Peipei Wei, Deli Xiao & Bangxin Han. (2020) Sinapultide-Loaded Microbubbles Combined with Ultrasound to Attenuate Lipopolysaccharide-Induced Acute Lung Injury in Mice. Drug Design, Development and Therapy 14, pages 5611-5622.
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Hussein H. Genedy, Paul Humbert, Bilel Laoulaou, Brian Le Moal, Marion Fusellier, Catherine Passirani, Catherine Le Visage, Jérôme Guicheux, Élise Lepeltier & Johann Clouet. (2024) MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration. Advanced Drug Delivery Reviews 207, pages 115214.
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Honglin Xiang, Weikang Zhao, Ke Jiang, Jiangtao He, Lu Chen, Wenguo Cui & Yuling Li. (2024) Progress in regulating inflammatory biomaterials for intervertebral disc regeneration. Bioactive Materials 33, pages 506-531.
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Hong Zhang, Xiaorong Yang, Yiheng Huang, Yue Li, Quan Hu, Qiaolin Wei, Weixing Xu, Weiguo Ding, Yong Guo & Jia-Wei Shen. (2024) Reviving Intervertebral Discs: Treating Degeneration Using Advanced Delivery Systems. Molecular Pharmaceutics 21:2, pages 373-392.
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Dazheng Sun, Guanglin Zhang, Mingyang Xie, Yina Wang, Xiangchao Liang, Mei Tu, Zhijian Su & Rong Zeng. (2023) Softness enhanced macrophage-mediated therapy of inhaled apoptotic-cell-inspired nanosystems for acute lung injury. Journal of Nanobiotechnology 21:1.
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Wenzhao Liu, Zhanjun Ma, Yonggang Wang & Jingjing Yang. (2023) Multiple nano-drug delivery systems for intervertebral disc degeneration: Current status and future perspectives. Bioactive Materials 23, pages 274-299.
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Zongtai Liu, Jiabo Zhu, Haiyan Liu & Changfeng Fu. (2023) Natural products can modulate inflammation in intervertebral disc degeneration. Frontiers in Pharmacology 14.
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Jianqing Peng, Qin Wang, Mingyang Guo, Chunyuan Liu, Xuesheng Chen, Ling Tao, Ke Zhang & Xiangchun Shen. (2022) Development of Inhalable Chitosan-Coated Oxymatrine Liposomes to Alleviate RSV-Infected Mice. International Journal of Molecular Sciences 23:24, pages 15909.
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Zongtai Liu & Changfeng Fu. (2022) Application of single and cooperative different delivery systems for the treatment of intervertebral disc degeneration. Frontiers in Bioengineering and Biotechnology 10.
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Yifan Ding, Huan Wang, Yunyun Wang, Long Li, Jiahui Ding, Caiyan Yuan, Tao Xu, Haoran Xu, Hui Xie, Ning Zhu, Xin Hu, Huang Fang & Songwei Tan. (2022) Co-delivery of luteolin and TGF-β1 plasmids with ROS-responsive virus-inspired nanoparticles for microenvironment regulation and chemo-gene therapy of intervertebral disc degeneration. Nano Research 15:9, pages 8214-8227.
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Jianqing Peng, Zimin Cai, Qin Wang, Jia Zhou, Jinzhuan Xu, Di Pan, Tingting Chen, Guangqiong Zhang, Ling Tao, Yi Chen & Xiangchun Shen. (2022) Carboxymethyl Chitosan Modified Oxymatrine Liposomes for the Alleviation of Emphysema in Mice via Pulmonary Administration. Molecules 27:11, pages 3610.
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Hai-Wei Chen, Guang-Zhi Zhang, Ming-Qiang Liu, Li-Juan Zhang, Ji-He Kang, Zhao-Heng Wang, Wen-Zhao Liu, Ai-Xin Lin & Xue-Wen Kang. (2021) Natural Products of Pharmacology and Mechanisms in Nucleus Pulposus Cells and Intervertebral Disc Degeneration. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-22.
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Oana Craciunescu, Madalina Icriverzi, Paula Ecaterina Florian, Anca Roseanu & Mihaela Trif. (2021) Mechanisms and Pharmaceutical Action of Lipid Nanoformulation of Natural Bioactive Compounds as Efficient Delivery Systems in the Therapy of Osteoarthritis. Pharmaceutics 13:8, pages 1108.
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Qing Tang, Wei Zhang, Chong Zhang, Yang Guan, Jiahui Ding, Caiyan Yuan, Chen Tan, Xueqin Gao & Songwei Tan. (2020) Oxymatrine loaded nitric oxide-releasing liposomes for the treatment of ulcerative colitis. International Journal of Pharmaceutics 586, pages 119617.
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