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Drug Design, Development and Therapy Volume 14, 2020 - Issue
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Original Research

Sarsasapogenin Suppresses RANKL-Induced Osteoclastogenesis in vitro and Prevents Lipopolysaccharide-Induced Bone Loss in vivo

Jiaxuan Peng1 Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Guangxi 530021, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-5044-4433
ORCID Icon,
Kangxian Zhao2 The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, People’s Republic of China
,
Jiling Zhu3 Department of Clinical Medicine, Medical College of Shaoxing University, Shaoxing, Zhejiang 312000, People’s Republic of China
,
Yanben Wang4 Department of Orthopaedics, Shaoxing People’s Hospital, Zhejiang University School of Medicine, Shaoxing 312000, Zhejiang, People’s Republic of China;5 Department of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China
,
Peng Sun2 The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, People’s Republic of China
,
Qichang Yang2 The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, People’s Republic of China
,
Tan Zhang4 Department of Orthopaedics, Shaoxing People’s Hospital, Zhejiang University School of Medicine, Shaoxing 312000, Zhejiang, People’s Republic of China
,
Weiqi Han4 Department of Orthopaedics, Shaoxing People’s Hospital, Zhejiang University School of Medicine, Shaoxing 312000, Zhejiang, People’s Republic of China
,
Wenjun Hu4 Department of Orthopaedics, Shaoxing People’s Hospital, Zhejiang University School of Medicine, Shaoxing 312000, Zhejiang, People’s Republic of China
,
Wanlei Yang4 Department of Orthopaedics, Shaoxing People’s Hospital, Zhejiang University School of Medicine, Shaoxing 312000, Zhejiang, People’s Republic of China
,
Jianwei Ruan6 Department of Orthopaedics, Taizhou Municipal Hospital, Taizhou 318000, Zhejiang, Republic of China
&
Yu Qian1 Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Guangxi 530021, People’s Republic of China;2 The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, People’s Republic of China;4 Department of Orthopaedics, Shaoxing People’s Hospital, Zhejiang University School of Medicine, Shaoxing 312000, Zhejiang, People’s Republic of ChinaCorrespondence[email protected]
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Pages 3435-3447 | Published online: 24 Aug 2020

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Jiacheng Sun, Guoping Cai, Jinlong Shen, Pu Cheng, Jiapeng Zhang, Dengteng Jiang, Xianquan Xu, Fangying Lu, Lihua Chen & Haixiao Chen. (2023) AS-605240 Blunts Osteoporosis by Inhibition of Bone Resorption. Drug Design, Development and Therapy 17, pages 1275-1288.
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Xinhui Wu, Kangxian Zhao, Xiaoxin Fang, Feng Lu, Weikang Zhang, Xiaoting Song, Lihua Chen, Jiacheng Sun & Haixiao Chen. (2021) Inhibition of Lipopolysaccharide-Induced Inflammatory Bone Loss by Saikosaponin D is Associated with Regulation of the RANKL/RANK Pathway. Drug Design, Development and Therapy 15, pages 4741-4757.
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Nur Hanisah Mustafa, Mahendran Sekar, Shivkanya Fuloria, M. Yasmin Begum, Siew Hua Gan, Nur Najihah Izzati Mat Rani, Subban Ravi, Kumarappan Chidambaram, Vetriselvan Subramaniyan, Kathiresan V. Sathasivam, Srikanth Jeyabalan, Subasini Uthirapathy, Sivasankaran Ponnusankar, Pei Teng Lum, Vijay Bhalla & Neeraj Kumar Fuloria. (2022) Chemistry, Biosynthesis and Pharmacology of Sarsasapogenin: A Potential Natural Steroid Molecule for New Drug Design, Development and Therapy. Molecules 27:6, pages 2032.
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