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Drug Design, Development and Therapy Volume 14, 2020 - Issue
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Original Research

Tranilast Inhibits Pulmonary Fibrosis by Suppressing TGFβ/SMAD2 Pathway

Motoyasu Kato1 Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan;2 Research Institute for Diseases of Old Ages, Juntendo University Graduate School of Medicine, Tokyo, JapanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3217-5118
ORCID Icon,
Fumiyuki Takahashi1 Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan;2 Research Institute for Diseases of Old Ages, Juntendo University Graduate School of Medicine, Tokyo, Japan
,
Tadashi Sato1 Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan;2 Research Institute for Diseases of Old Ages, Juntendo University Graduate School of Medicine, Tokyo, JapanORCID Iconhttps://orcid.org/0000-0003-0467-8217
ORCID Icon,
Yoichiro Mitsuishi1 Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan;2 Research Institute for Diseases of Old Ages, Juntendo University Graduate School of Medicine, Tokyo, Japan
,
Ken Tajima1 Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan;2 Research Institute for Diseases of Old Ages, Juntendo University Graduate School of Medicine, Tokyo, Japan
,
Hiroaki Ihara1 Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan;2 Research Institute for Diseases of Old Ages, Juntendo University Graduate School of Medicine, Tokyo, JapanORCID Iconhttps://orcid.org/0000-0002-1225-6930
ORCID Icon,
Fariz Nurwidya1 Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan;2 Research Institute for Diseases of Old Ages, Juntendo University Graduate School of Medicine, Tokyo, JapanORCID Iconhttps://orcid.org/0000-0002-8379-9510
ORCID Icon,
Hario Baskoro1 Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan;2 Research Institute for Diseases of Old Ages, Juntendo University Graduate School of Medicine, Tokyo, Japan
,
Akiko Murakami1 Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan;2 Research Institute for Diseases of Old Ages, Juntendo University Graduate School of Medicine, Tokyo, Japan
,
Isao Kobayashi1 Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan;2 Research Institute for Diseases of Old Ages, Juntendo University Graduate School of Medicine, Tokyo, Japan
,
Moulid Hidayat1 Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan;2 Research Institute for Diseases of Old Ages, Juntendo University Graduate School of Medicine, Tokyo, JapanORCID Iconhttps://orcid.org/0000-0001-5526-2700
ORCID Icon,
Naoko Shimada1 Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan;2 Research Institute for Diseases of Old Ages, Juntendo University Graduate School of Medicine, Tokyo, Japan;3 Leading Center for the Development and Research of Cancer Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
,
Shinichi Sasaki1 Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan;2 Research Institute for Diseases of Old Ages, Juntendo University Graduate School of Medicine, Tokyo, Japan
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Reiko Mineki4 Laboratory of Proteomics and Biomolecular Science, Research Support Center, Juntendo University Graduate School of Medicine, Tokyo, Japan
,
Tsutomu Fujimura5 Laboratory of Bioanalytical Chemistry, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan
,
Toshio Kumasaka6 Department of Pathology, Japanese Red Cross Medical Center, Tokyo, Japan
,
Shin-ichiro Niwa7 Link Genomics, Incorporated, Tokyo, Japan
&
Kazuhisa Takahashi1 Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan;2 Research Institute for Diseases of Old Ages, Juntendo University Graduate School of Medicine, Tokyo, Japan;3 Leading Center for the Development and Research of Cancer Medicine, Juntendo University Graduate School of Medicine, Tokyo, JapanORCID Iconhttps://orcid.org/0000-0001-5749-4118
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Pages 4593-4603 | Published online: 29 Oct 2020

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Ali Saeedi-Boroujeni, Mohammad-Reza Mahmoudian-Sani, Roohangiz Nashibi, Sheyda Houshmandfar, Sima Tahmaseby Gandomkari & Ali Khodadadi. (2021) Tranilast: a potential anti-Inflammatory and NLRP3 inflammasome inhibitor drug for COVID-19. Immunopharmacology and Immunotoxicology 43:3, pages 247-258.
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Youquan Chen, Ming Huang, Yi Yan & Dequan He. (2021) Tranilast inhibits angiotensin II-induced myocardial fibrosis through S100A11/ transforming growth factor-β (TGF-β1)/Smad axis. Bioengineered 12:1, pages 8447-8456.
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Sharav A. Desai, Vipul P. Patel, Kunal P. Bhosle, Sandip D. Nagare & Kirti C. Thombare. The tumor microenvironment: shaping cancer progression and treatment response. Journal of Chemotherapy 0:0, pages 1-30.
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Xiaotong Wang, Di Zhang, Yaxue Zhu, Daojie Li, Long Shen, Qiankun Wang, Yun Gao, Xiaoping Li & Mei Yu. (2024) Protein lysine acetylation played an important role in NH3-induced AEC2 damage and pulmonary fibrosis in piglets. Science of The Total Environment 908, pages 168303.
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Dongke Yu, Yu Xiang, Tingting Gou, Rongsheng Tong, Chuan Xu, Lu Chen, Ling Zhong & Jianyou Shi. (2023) New therapeutic approaches against pulmonary fibrosis. Bioorganic Chemistry 138, pages 106592.
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Zhangsong Peng, Qiang Chang, Xilong Liu, Danni Chen, Feng Lu & Xihang Chen. (2023) Polydopamine-assisted tranilast immobilization on a PLA chamber to enhance fat flaps regeneration by reducing tissue fibrosis. RSC Advances 13:14, pages 9195-9207.
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Yufeng Lou, Zhenrong Huang, Hui Wu & Yun Zhou. (2022) Tranilast attenuates lipopolysaccharide‑induced lung injury via the CXCR4/JAK2/STAT3 signaling pathway. Molecular Medicine Reports 26:1.
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Ke Xue, Shuai Chen, Jiayin Chai, Wenjing Yan, Xinyu Zhu, Hongyan DaiWen Wang. (2022) Upregulation of Periostin Through CREB Participates in Myocardial Infarction-induced Myocardial Fibrosis. Journal of Cardiovascular Pharmacology 79:5, pages 687-697.
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Carol M. Artlett. (2022) The Mechanism and Regulation of the NLRP3 Inflammasome during Fibrosis. Biomolecules 12:5, pages 634.
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Harsh Vardhan Charan, Durgesh Kumar Dwivedi, Sabbir Khan & Gopabandhu Jena. (2022) Mechanisms of NLRP3 inflammasome-mediated hepatic stellate cell activation: Therapeutic potential for liver fibrosis. Genes & Diseases.
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Sabrina Blumer, Lei Fang, Wei-Chih Chen, Petra Khan, Katrin Hostettler, Michael Tamm, Michael Roth & Christopher Lambers. (2021) IPF-Fibroblast Erk1/2 Activity Is Independent from microRNA Cluster 17-92 but Can Be Inhibited by Treprostinil through DUSP1. Cells 10:11, pages 2836.
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