Advanced search
Publication Cover
Drug Design, Development and Therapy Volume 15, 2021 - Issue
Submit an article Journal homepage
189
Views
16
CrossRef citations to date
0
Altmetric
Original Research

Taxifolin, Extracted from Waste Larix olgensis Roots, Attenuates CCl4-Induced Liver Fibrosis by Regulating the PI3K/AKT/mTOR and TGF-β1/Smads Signaling Pathways

Xinglong Liu1 College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, People’s Republic of China
,
Wencong Liu1 College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, People’s Republic of China;2 State Local Joint Engineering Research Center of Ginseng Breeding and Application, Changchun 130118, People’s Republic of ChinaCorrespondence[email protected]
,
Chuanbo Ding1 College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, People’s Republic of China
,
Yingchun Zhao1 College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, People’s Republic of China
,
Xueyan Chen1 College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, People’s Republic of China
,
Dong Ling1 College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, People’s Republic of China
,
Yinan Zheng1 College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, People’s Republic of China
&
Zhiqiang Cheng3 College of Resources and Environment, Jilin Agricultural University, Changchun 130118, People’s Republic of China
 show all
Pages 871-887 | Published online: 26 Feb 2021

Citations (16)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Yusheng Zhao, Hui Kong, Yuru Li, Yafang Zhao, Yue Zhang, Yan Zhao & Huihua Qu. (2024) Inhibitory effects of Curcumae Radix carbonisata-based carbon dots against liver fibrosis induced by carbon tetrachloride in mice. Artificial Cells, Nanomedicine, and Biotechnology 52:1, pages 23-34.
Read now

Articles from other publishers (15)

Yafang Zhao, Ertong Dai, Liyang Dong, Jinye Yuan, Yusheng Zhao, Tong Wu, Ruolan Kong, Menghan Li, Shuxian Wang, Long Zhou, Yingxin Yang, Hui Kong, Yan Zhao & Huihua Qu. (2023) Available and novel plant-based carbon dots derived from Vaccaria Semen carbonisata alleviates liver fibrosis. Frontiers in Molecular Biosciences 10.
Crossref
Hongyi Jiang, Chihao Lin, Tingwen Cai, Liting Jiang, Chao Lou, Shida Lin, Weidan Wang, Zijian Yan, Xiaoyun Pan & Xinghe Xue. (2023) Taxifolin‐mediated Nrf2 activation ameliorates oxidative stress and apoptosis for the treatment of glucocorticoid‐induced osteonecrosis of the femoral head. Phytotherapy Research.
Crossref
Rong Yang, Xinxing Yang & Feng Zhang. (2023) New Perspectives of Taxifolin in Neurodegenerative Diseases. Current Neuropharmacology 21:10, pages 2097-2109.
Crossref
Guang-Xian Hu, Xiao-Fen Xie, Tian-Hong Yuan, Min Shuai, Jin-Juan Zhang, Dan Zhou, Jiu-Qiong Chen, Miao Ran, Lan Wang, Yong-Li, Mao-Qiong Chen, Zhen-Kui Ren & Jian-Wei Xu. (2023) Protective effect of water extracts of Veronicastrum latifolium (Hemsl.) Yamazaki on carbon tetrachloride-induced liver fibrosis in mice and its effect on intestinal flora. Fitoterapia 170, pages 105653.
Crossref
Ivan Gmoshinski, Mikhail Ananyan, Vladimir Shipelin, Nikolay Riger, Eleonora Trushina, Oksana Mustafina, Galina Guseva, Anastasya Balakina, Alexey Kolobanov, Sergey Khotimchenko & Dmitriy Ozherelkov. (2023) Effect of dihydroquercetin on the toxic properties of nickel nanoparticles. Foods and Raw Materials, pages 232-242.
Crossref
Yu Zheng, Long Xie, Dejun Yang, Kaipei Luo & Xiaofang Li. (2023) Small-molecule natural plants for reversing liver fibrosis based on modulation of hepatic stellate cells activation: An update. Phytomedicine 113, pages 154721.
Crossref
Chaojie Chen, Jiajun Chen, Ying Wang, Liu Fang, Cuiling Guo, Tingting Sang, He Peng, Qian Zhao, Shengjia Chen, Xiaojian Lin & Xingya Wang. (2023) Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-β/Smad signaling. Phytomedicine 110, pages 154626.
Crossref
Takayuki Inoue, Bin Fu, Miwako Nishio, Miyako Tanaka, Hisashi Kato, Masashi Tanaka, Michiko Itoh, Hajime Yamakage, Kozue Ochi, Ayaka Ito, Yukihiro Shiraki, Satoshi Saito, Masafumi Ihara, Hideo Nishimura, Atsuhiko Kawamoto, Shian Inoue, Kumiko Saeki, Atsushi Enomoto, Takayoshi Suganami & Noriko Satoh-Asahara. (2023) Novel Therapeutic Potentials of Taxifolin for Obesity-Induced Hepatic Steatosis, Fibrogenesis, and Tumorigenesis. Nutrients 15:2, pages 350.
Crossref
Heba M. Obeidat, Osama Y. Althunibat, Manal A. Alfwuaires, Saleem H. Aladaileh, Abdulmohsen I. Algefare, Afaf F. Almuqati, Fawaz Alasmari, Hammad Khalifeh Aldal’in, Abdulkareem A. Alanezi, Bader Alsuwayt & Mohammad H. Abukhalil. (2022) Cardioprotective Effect of Taxifolin against Isoproterenol-Induced Cardiac Injury through Decreasing Oxidative Stress, Inflammation, and Cell Death, and Activating Nrf2/HO-1 in Mice. Biomolecules 12:11, pages 1546.
Crossref
Yexun Zhou, Liang Chen, Hui Han, Bohui Xiong, Ruqing Zhong, Yue Jiang, Lei Liu, Haiqing Sun, Jiajian Tan, Xiaowei Cheng, Martine Schroyen, Yang Gao, Yong Zhao & Hongfu Zhang. (2022) Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites. Frontiers in Microbiology 13.
Crossref
Liwei Huang, Hanfeng Tang & Jianzhang Hu. (2022) METTL3 Attenuates Inflammation in Fusarium solani –Induced Keratitis via the PI3K/AKT Signaling Pathway . Investigative Opthalmology & Visual Science 63:10, pages 20.
Crossref
Qiteng Ding, Kecheng Chen, Xinglong Liu, Chuanbo Ding, Yingchun Zhao, Shuwen Sun, Yiwen Zhang, Jinping Zhang, Shuang Liu & Wencong Liu. (2022) Modification of taxifolin particles with an enteric coating material promotes repair of acute liver injury in mice through modulation of inflammation and autophagy signaling pathway. Biomedicine & Pharmacotherapy 152, pages 113242.
Crossref
Qiteng Ding, Wencong Liu, Xinglong Liu, Chuanbo Ding, Yingchun Zhao, Ling Dong, Huiying Chen, Shuwen Sun, Yiwen Zhang, Jinping Zhang & Ming Wu. (2022) Polyvinylpyrrolidone-Modified Taxifolin Liposomes Promote Liver Repair by Modulating Autophagy to Inhibit Activation of the TLR4/NF-κB Signaling Pathway. Frontiers in Bioengineering and Biotechnology 10.
Crossref
Leyong Yuan, Yan Sun, Ning Zhou, Weipeng Wu, Weidong Zheng & Yukun Wang. (2022) Dihydroquercetin Attenuates Silica-Induced Pulmonary Fibrosis by Inhibiting Ferroptosis Signaling Pathway. Frontiers in Pharmacology 13.
Crossref
Xing-Long Liu, Ying-Chun Zhao, Hong-Yan Zhu, Ming Wu, Yi-Nan Zheng, Min Yang, Zhi-Qiang Cheng, Chuan-Bo Ding & Wen-Cong Liu. (2021) Taxifolin retards the d -galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice . Food & Function 12:23, pages 12142-12158.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.