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Drug Design, Development and Therapy Volume 15, 2021 - Issue
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Original Research

Synthesis of Michael Adducts as Key Building Blocks for Potential Analgesic Drugs: In vitro, in vivo and in silico Explorations

Sajjad Ahmad1 Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Khyber Pakhtunkhwa, Pakistan
,
Mater H Mahnashi2 Department of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran, Saudi Arabia
,
Bandar A Alyami2 Department of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran, Saudi Arabia
,
Yahya S Alqahtani2 Department of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran, Saudi ArabiaORCID Iconhttps://orcid.org/0000-0001-8816-1842
ORCID Icon,
Farhat Ullah1 Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Khyber Pakhtunkhwa, Pakistan
,
Muhammad Ayaz1 Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Khyber Pakhtunkhwa, PakistanORCID Iconhttps://orcid.org/0000-0002-4299-2445
ORCID Icon,
Muhammad Tariq3 Department PCB, Rokhan University, Jalalabad, Nangrahar, AfghanistanORCID Iconhttps://orcid.org/0000-0002-5779-8370
ORCID Icon,
Abdul Sadiq1 Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Khyber Pakhtunkhwa, PakistanCorrespondence[email protected]
&
Umer Rashid4 Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, PakistanCorrespondence[email protected]
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Pages 1299-1313 | Published online: 23 Mar 2021

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Taghrid S. AlOmar, Abdur Rauf, Umer Rashid, Sehrish Sarfaraz, Khurshid Ayub, Fahad Hussain, Najla Almasoud, Abdulaziz S. AlOmar, Gauhar Rehman, Zubair Ahmad, Naveed Muhammad & Zafar Ali Shah. (2023) Molecular docking, DFT studies, and anti-inflammatory evaluation of peshawaraquinone isolated from Fernandoa adenophylla. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-13.
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Khista Rahman, Gowhar Ali, Rasool Khan, Imad Khan, Izaz Ali, Osama F Mosa, Alshebli Ahmed, Muhammad Ayaz, Asif Nawaz & H C Ananda Murthy. (2022) Analagesic and Anti-Inflammatory Potentials of a Less Ulcerogenic Thiadiazinethione Derivative in Animal Models: Biochemical and Histochemical Correlates. Drug Design, Development and Therapy 16, pages 1143-1157.
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Rehman Zafar, Humaira Naureen, Muhammad Zubair, Khadija Shahid, Muhammad Saeed Jan, Samar Akhtar, Hammad Ahmad, Wajeeha Waseem, Ali Haider, Saqib Ali, Muhammad Tariq & Abdul Sadiq. (2021) Prospective Application of Two New Pyridine-Based Zinc (II) Amide Carboxylate in Management of Alzheimer’s Disease: Synthesis, Characterization, Computational and in vitro Approaches. Drug Design, Development and Therapy 15, pages 2679-2694.
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Mater H. Mahnashi, Muhammad Ayaz, Yahya S. Alqahtani, Bandar A. Alyami, Muhammad Shahid, Omaish Alqahtani, Saeed M. Kabrah, Alam Zeb, Farhat Ullah & Abdul Sadiq. (2023) Quantitative-HPLC-DAD polyphenols analysis, anxiolytic and cognition enhancing potentials of Sorbaria tomentosa Lindl. Rehder. Journal of Ethnopharmacology 317, pages 116786.
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Silvia Vera, Aitor Landa, Antonia Mielgo, Iñaki Ganboa, Mikel Oiarbide & Vadim Soloshonok. (2023) Catalytic Asymmetric α-Functionalization of α-Branched Aldehydes. Molecules 28:6, pages 2694.
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Evgeny G. Rys, Victoria M. Alpatova, Elena G. Kononova, Alexander F. Smol’yakov, Sergey K. Moiseev & Valentina A. Ol'shevskaya. (2022) Employment of Michael addition reactions for the functionalization of carboranes. New Journal of Chemistry 46:37, pages 18025-18032.
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Muhammad Imran Qayyum, Sami Ullah, Umer Rashid, Abdul Sadiq, Obaidullah, Mater H. Mahnashi, Osama M. Alshehri, Mohammed M. Jalal, Khalid J. Alzahrani & Ibrahim F. Halawani. (2022) Synthesis, Molecular Docking, and Preclinical Evaluation of a New Succinimide Derivative for Cardioprotective, Hepatoprotective and Lipid-Lowering Effects. Molecules 27:19, pages 6199.
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Viktória Kozma, Zsolt Szakonyi & György Szőllősi. (2022) β-Amino Acid Organocatalysts in the Asymmetric Michael Addition of Isobutyraldehyde to N-Substituted Maleimides. Catalysts 12:9, pages 992.
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Viktória Kozma & György Szőllősi. (2022) Enantioselective Michael addition of aldehydes to maleimides catalysed by surface-adsorbed natural amino acids. Catalysis Science & Technology 12:15, pages 4709-4726.
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Osama M. Alshehri, Mater H. Mahnashi, Abdul Sadiq, Rehman Zafar, Muhammad Saeed Jan, Farhat Ullah, Mohammed Ali Alshehri, Saleh Alshamrani & Elhashimi E. Hassan. (2022) Succinimide Derivatives as Antioxidant Anticholinesterases, Anti-α-Amylase, and Anti-α-Glucosidase: In Vitro and In Silico Approaches. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-12.
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Fawad Mahmood, Jamshaid Ali Khan, Mater H. Mahnashi, Muhammad Saeed Jan, Muhammad Aamir Javed, Umer Rashid, Abdul Sadiq, Syed Shams ul Hassan & Simona Bungau. (2022) Anti-Inflammatory, Analgesic and Antioxidant Potential of New (2S,3S)-2-(4-isopropylbenzyl)-2-methyl-4-nitro-3-phenylbutanals and Their Corresponding Carboxylic Acids through In Vitro, In Silico and In Vivo Studies. Molecules 27:13, pages 4068.
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Mater H. Mahnashi, Yahya S. Alqahtani, Bandar A. Alyami, Ali O. Alqarni, Mohammad Ahmed Alshrahili, Mahrous A. Abou-Salim, Mohammed N. Alqahtani, Sadaf Mushtaq, Abdul Sadiq & Muhammad Saeed Jan. (2022) GC-MS Analysis and Various In Vitro and In Vivo Pharmacological Potential of Habenaria plantaginea Lindl.. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-13.
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Viktória Kozma & György Szőllősi. (2022) Conjugate addition of 1,3-dicarbonyl compounds to maleimides using bifunctional primary amine‒(thio)phosphoramide organocatalysts. Molecular Catalysis 518, pages 112089.
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