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Drug Design, Development and Therapy Volume 15, 2021 - Issue
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Original Research

Predicting and Exploring the Mechanisms of Erzhi Pill in Prevention and Treatment of Osteoporosis Based on Network Pharmacology and Zebrafish Experiments

Zhiguo Zhong1 Traditional Chinese Medicine Department, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524023, People’s Republic of ChinaView further author information
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Yuyun Li2 Department of Pharmacology, School of Pharmacy, Guangdong Key Laboratory for Research and Development of Natural Drugs, Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023, People’s Republic of China;3 Institute of Traditional Chinese Medicine and New Pharmacy Development, Guangdong Medical University, Dongguan, 523808, People’s Republic of ChinaView further author information
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Yan Chen2 Department of Pharmacology, School of Pharmacy, Guangdong Key Laboratory for Research and Development of Natural Drugs, Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023, People’s Republic of China;3 Institute of Traditional Chinese Medicine and New Pharmacy Development, Guangdong Medical University, Dongguan, 523808, People’s Republic of ChinaView further author information
,
Wen Chen2 Department of Pharmacology, School of Pharmacy, Guangdong Key Laboratory for Research and Development of Natural Drugs, Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023, People’s Republic of ChinaView further author information
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Siyan Li4 School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, People’s Republic of ChinaView further author information
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Xiaohua Lv2 Department of Pharmacology, School of Pharmacy, Guangdong Key Laboratory for Research and Development of Natural Drugs, Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023, People’s Republic of ChinaView further author information
&
Shiying Luo2 Department of Pharmacology, School of Pharmacy, Guangdong Key Laboratory for Research and Development of Natural Drugs, Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8235-9057View further author information
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Pages 817-827 | Published online: 24 Feb 2021

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Fang-Jun Lin, Hang Li, Ding-Tao Wu, Qi-Guo Zhuang, Hua-Bin Li, Fang Geng & Ren-You Gan. (2022) Recent development in zebrafish model for bioactivity and safety evaluation of natural products. Critical Reviews in Food Science and Nutrition 62:31, pages 8646-8674.
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Articles from other publishers (7)

Yue Wang, Haohao Wang, Chunyu Gao, Yan Zhao, Zhongmei He, Weijia Chen, Ying Zong & Rui Du. (2023) Analysis of network pharmacology and experimental verification to explore the mechanism of Modified Guilu Erxian Glue in the treatment of low immune function. Pharmacological Research - Modern Chinese Medicine 7, pages 100213.
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Xiang Jin, Hong Wang, Fan Li, Xuechao Liang, Xiaoni Deng, Shuo Gao, Kang Ru, Wuxia Qiu, Ying Huai, Jiaqi Zhang, Linbin Lai, Zhiping Miao, Wenjuan Zhang & Airong Qian. (2022) Formononetin ameliorates simulated microgravity-induced bone loss by suppressing bone turnover in rats. Acta Astronautica 200, pages 77-85.
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Xia Cao, Qing He, Michael Adu-Frimpong, Xinyi Shen, Wanjing Rong, Xiaoxiao Li, Jian Zhang, Xiaoli Xia, Feng Shi, Hao Ji, Elmurat Toreniyazov, Qilong Wang, Jiangnan Yu & Ximing Xu. (2022) Preparation of Pinocembrin-Loaded F127/MPEG-PDLLA Polymer Micelles and Anti-Osteoporotic Activity. AAPS PharmSciTech 23:7.
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Yue Hu, Liang Yang, Yunfei Lu, Yong Wang, Jianshuai Jiang, Yahui Liu & Qing Cao. (2022) Systems Network Pharmacology-Based Prediction and Analysis of Potential Targets and Pharmacological Mechanism of Actinidia chinensis Planch. Root Extract for Application in Hepatocellular Carcinoma. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-17.
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Ting Ouyang, Huafeng Yin, Jianbo Yang, Yue Liu & Shuangcheng Ma. (2022) Tissue regeneration effect of betulin via inhibition of ROS/MAPKs/NF-ĸB axis using zebrafish model. Biomedicine & Pharmacotherapy 153, pages 113420.
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Xiang Jin, Hong Wang, Xuechao Liang, Kang Ru, Xiaoni Deng, Shuo Gao, Wuxia Qiu, Ying Huai, Jiaqi Zhang, Linbin Lai, Fan Li, Zhiping Miao, Wenjuan Zhang & Airong Qian. (2022) Calycosin prevents bone loss induced by hindlimb unloading. npj Microgravity 8:1.
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Huihao Zhang, Chengcong Zhou, Zhiguo Zhang, Sai Yao, Yishan Bian, Fangda Fu, Huan Luo, Yan Li, Shuxin Yan, Yuying Ge, Yuying Chen, Kunyu Zhan, Ming Yue, Weibin Du, Kun Tian, Hongting Jin, Xiaofeng Li, Peijian Tong, Hongfeng Ruan & Chengliang Wu. (2022) Integration of Network Pharmacology and Experimental Validation to Explore the Pharmacological Mechanisms of Zhuanggu Busui Formula Against Osteoporosis. Frontiers in Endocrinology 12.
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