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Drug Design, Development and Therapy Volume 15, 2021 - Issue
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Original Research

The Jieduan-Niwan (JDNW) Formula Ameliorates Hepatocyte Apoptosis: A Study of the Inhibition of E2F1-Mediated Apoptosis Signaling Pathways in Acute-on-Chronic Liver Failure (ACLF) Using Rats

Weixin Hou1 Department of Hepatology, School of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China;2 Department of Hepatology, Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research, Capital Medical University, Beijing, People’s Republic of China;3 Department of Endocrinology, School of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China;4 Department of Endocrinology, Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research, Capital Medical University, Beijing, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-8451-6335
ORCID Icon,
Yulin Hao1 Department of Hepatology, School of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China;2 Department of Hepatology, Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research, Capital Medical University, Beijing, People’s Republic of China
,
Wenlong Yang1 Department of Hepatology, School of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China;2 Department of Hepatology, Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research, Capital Medical University, Beijing, People’s Republic of China
,
Tian Tian1 Department of Hepatology, School of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China;2 Department of Hepatology, Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research, Capital Medical University, Beijing, People’s Republic of China
,
Peng Fang1 Department of Hepatology, School of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China;2 Department of Hepatology, Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research, Capital Medical University, Beijing, People’s Republic of China
,
Yuqiong Du1 Department of Hepatology, School of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China;2 Department of Hepatology, Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research, Capital Medical University, Beijing, People’s Republic of China
,
Lianyin Gao1 Department of Hepatology, School of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China;2 Department of Hepatology, Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research, Capital Medical University, Beijing, People’s Republic of China
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Yanbin Gao3 Department of Endocrinology, School of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China;4 Department of Endocrinology, Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence[email protected]
&
Qiuyun Zhang1 Department of Hepatology, School of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China;2 Department of Hepatology, Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence[email protected]
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Pages 3845-3862 | Published online: 08 Sep 2021

Citations (9)

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Weixin Hou, Xiaoyi Wei, Jiajun Liang, Peng Fang, Chongyang Ma, Qiuyun Zhang & Yanbin Gao. (2021) HMGB1-Induced Hepatocyte Pyroptosis Expanding Inflammatory Responses Contributes to the Pathogenesis of Acute-on-Chronic Liver Failure (ACLF). Journal of Inflammation Research 14, pages 7295-7313.
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Articles from other publishers (8)

Jing Li, Qi Huang, Wenfeng Ma, JinYu Yi, Xin Zhong, Rui Hu, Jialing Sun, MengQing Ma, Minling Lv, Zhiyi Han, Wei Zhang, Wenxing Feng, Xinfeng Sun & Xiaozhou Zhou. (2024) Hepatoprotective efficacy and interventional mechanism of JianPi LiShi YangGan formula in acute-on-chronic liver failure. Journal of Ethnopharmacology 318, pages 116880.
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Jiajun Liang, Xiaoyi Wei, Weixin Hou, Hanjing Wang, Ruimin Ma, Yanbin Gao, Yuqiong Du & Qiuyun Zhang. (2023) Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle. Chinese Medicine 18:1.
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Jia-shu Chen, Xu Guo, Jin-yue Sun, Mu-xuan Wang, Xiu-zheng Gao, Zhen Wang, Jin-long Han, Hui Sun, Kai Zhang & Chao Liu. (2023) Fangchinoline derivatives inhibits PI3K signaling in vitro and in vivo in non-small cell lung cancer. Bioorganic Chemistry 138, pages 106623.
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Zhiyong Ren, Liguo Tang, Zhonghua Ding, Jun Song, Hailiang Zheng & Dongzhu Li. (2023) Dried root of Rehmannia glutinosa extracts prevents steroid-induced avascular necrosis of femoral head by activating the wingless-type (Wnt)/β-catenin signal pathway. Toxicon 230, pages 107174.
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Hengben Zhai, Jinming Zhang, Dabao Shang, Chuanwu Zhu & Xiaogang Xiang. (2023) The progress to establish optimal animal models for the study of acute-on-chronic liver failure. Frontiers in Medicine 10.
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Ji Ma, Ruya Li, Fang Xu, Fang Zhu & Xiangwei Xu. (2023) Dehydrovomifoliol Alleviates Nonalcoholic Fatty Liver Disease via the E2F1/AKT/mTOR Axis: Pharmacophore Modeling and Molecular Docking Study. Evidence-Based Complementary and Alternative Medicine 2023, pages 1-12.
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Peng Fang, Bo Dou, Weixin Hou, Xiaoyi Wei, Jiajun Liang, Chongyang Ma & Qiuyun Zhang. (2022) Jieduan–Niwan Formula Ameliorates Oxidative Stress and Apoptosis in Acute-on-Chronic Liver Failure by Suppressing HMGB1/TLR-4/NF-κB Signaling Pathway: A Study In Vivo and In Vitro. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-15.
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Ke Shi, Qun Zhang, Jie Hou, Yi Zhang, Yufei Bi & Xianbo Wang. (2022) Evaluation of LiangXue JieDu Therapy in Combination With Western Medicine for Acute-On-Chronic Liver Failure: A Systematic Review and meta-Analysis. Frontiers in Pharmacology 13.
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