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Review

The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol

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Pages 1135-1148 | Published online: 04 Oct 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Sègbédé E. R. Tchéoubi, Casimir D. Akpovi, Frédérique Coppée, Anne-Emilie Declèves, Sophie Laurent, Clément Agbangla & Carmen Burtea. (2022) Molecular and cellular biology of PCSK9: impact on glucose homeostasis. Journal of Drug Targeting 30:9, pages 948-960.
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Amir Mohammad Malvandi, Laura Canclini, Anxhela Alliaj, Paolo Magni, Alberto Zambon & Alberico Luigi Catapano. (2020) Progress and prospects of biological approaches targeting PCSK9 for cholesterol-lowering, from molecular mechanism to clinical efficacy. Expert Opinion on Biological Therapy 20:12, pages 1477-1489.
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Brian Tomlinson, Paul Chan & Zhong-Min Liu. (2018) Prediction of response to lipid-lowering treatments. Expert Review of Precision Medicine and Drug Development 3:6, pages 335-337.
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Nicola Ferri, Alberto Corsini, Cesare R. Sirtori & Massimiliano Ruscica. (2017) Bococizumab for the treatment of hypercholesterolaemia. Expert Opinion on Biological Therapy 17:2, pages 237-243.
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Lingling Zhang, Kangping Song, Mengting Zhu, Jinling Shi, Huijuan Zhang, Liang Xu & Yingzhu Chen. (2016) Proprotein convertase subtilisin/kexin type 9 (PCSK9) in lipid metabolism, atherosclerosis and ischemic stroke. International Journal of Neuroscience 126:8, pages 675-680.
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Articles from other publishers (7)

Carmen Lammi, Enrico M. A. Fassi, Jianqiang Li, Martina Bartolomei, Giulia Benigno, Gabriella Roda, Anna Arnoldi & Giovanni Grazioso. (2022) Computational Design and Biological Evaluation of Analogs of Lupin Peptide P5 Endowed with Dual PCSK9/HMG-CoAR Inhibiting Activity. Pharmaceutics 14:3, pages 665.
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Vittoria Cammisotto, Francesco Baratta, Paola G. Simeone, Cristina Barale, Enrico Lupia, Gioacchino Galardo, Francesca Santilli, Isabella Russo & Pasquale Pignatelli. (2022) Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Beyond Lipids: The Role in Oxidative Stress and Thrombosis. Antioxidants 11:3, pages 569.
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Aureli Luquero, Lina Badimon & Maria Borrell-Pages. (2021) PCSK9 Functions in Atherosclerosis Are Not Limited to Plasmatic LDL-Cholesterol Regulation. Frontiers in Cardiovascular Medicine 8.
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Zhubing Li & Qiang Liu. (2018) Proprotein convertase subtilisin/kexin type 9 inhibits hepatitis C virus replication through interacting with NS5A. Journal of General Virology 99:1, pages 44-61.
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Andreea Milasan, François Dallaire, Gaétan Mayer & Catherine Martel. (2016) Effects of LDL Receptor Modulation on Lymphatic Function. Scientific Reports 6:1.
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Xintong Dong, Hui Chiu, Yeonhee Jenny Park, Wei Zou, Yan Zou, Engin Özkan, Chieh Chang & Kang Shen. (2016) Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions. eLife 5.
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Jean-Marc Lavoie. (2016) Dynamics of hepatic and intestinal cholesterol and bile acid pathways: The impact of the animal model of estrogen deficiency and exercise training. World Journal of Hepatology 8:23, pages 961.
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