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Original Research

Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis

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Pages 305-316 | Published online: 10 Apr 2013

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Read on this site (4)

Sayako Ikeda, Kana Kihira, Akira Yokoi, Koji Tamakoshi, Ken Miyazaki & Madoka Furuhashi. (2015) The levels of the neutrophil elastase in the amniotic fluid of pregnant women whose infants develop bronchopulmonary dysplasia. The Journal of Maternal-Fetal & Neonatal Medicine 28:4, pages 479-483.
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Naoki Aikawa & Yasushi Kawasaki. (2014) Clinical utility of the neutrophil elastase inhibitor sivelestat for the treatment of acute respiratory distress syndrome. Therapeutics and Clinical Risk Management 10, pages 621-629.
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Seigo Miyoshi, Ryoji Ito, Hitoshi Katayama, Kentaro Dote, Mayuki Aibiki, Hironobu Hamada, Takafumi Okura & Jitsuo Higaki. (2014) Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients. Drug Design, Development and Therapy 8, pages 1211-1219.
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Maria Gabriella Matera, Paola Rogliani, Josuel Ora, Luigino Calzetta & Mario Cazzola. A comprehensive overview of investigational elastase inhibitors for the treatment of acute respiratory distress syndrome. Expert Opinion on Investigational Drugs 0:0.
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Articles from other publishers (22)

Husayn F. Ramji, Maida Hafiz, Hiba Hammad Altaq, Syed Talal Hussain & Fawad Chaudry. (2023) Acute Respiratory Distress Syndrome; A Review of Recent Updates and a Glance into the Future. Diagnostics 13:9, pages 1528.
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Linlin Meng, Ximing Liao, Yuanyuan Wang, Liangzhi Chen, Wei Gao, Muyun Wang, Huiling Dai, Na Yan, Yixuan Gao, Xu Wu, Kun Wang & Qinghua Liu. (2022) Pharmacologic therapies of ARDS: From natural herb to nanomedicine. Frontiers in Pharmacology 13.
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Nedha Kinnare, Jessica S Hook, Parth A Patel, Nancy L Monson & Jessica G Moreland. (2021) Neutrophil Extracellular Trap Formation Potential Correlates with Lung Disease Severity in COVID-19 Patients. Inflammation 45:2, pages 800-811.
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Emma M. Lessieur, Haitao Liu, Aicha Saadane, Yunpeng Du, Jie Tang, Jianying Kiser & Timothy S. Kern. (2021) Neutrophil-Derived Proteases Contribute to the Pathogenesis of Early Diabetic Retinopathy. Investigative Opthalmology & Visual Science 62:13, pages 7.
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Jessica S. Hook, Parth A. Patel, Aidan O’Malley, Lihua Xie, Jeffrey S. Kavanaugh, Alexander R. Horswill & Jessica G. Moreland. (2021) Lipoproteins from Staphylococcus aureus Drive Neutrophil Extracellular Trap Formation in a TLR2/1- and PAD-Dependent Manner . The Journal of Immunology 207:3, pages 966-973.
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Helena Block & Alexander Zarbock. (2021) A Fragile Balance: Does Neutrophil Extracellular Trap Formation Drive Pulmonary Disease Progression?. Cells 10:8, pages 1932.
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Mingzhou Liu, Jing Zhang, Lingfang Dong, Wenhua Xue, Qilin He, Wenzhong Liang, Xing Liu, Jingying Zhang, Li Gu, Yinghua Feng, Jie Yang, Haibo Wang, Yaqin Wang, Kun Li, Yuanlong Li, Weiqin Kong, Xiaojian Zhang, Mengying Yao, Kai Wang, Peizhi Ma & Wei Zhang. (2021) Detection of sivelestat and its metabolite in small volumes of plasma from Chinese ALI/ARDS patients with SIRS via high-throughput UPLC-MS/MS: A pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis 195, pages 113876.
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Adeleh Sahebnasagh, Fatemeh Saghafi, Mohammadreza Safdari, Masoud Khataminia, Afsaneh Sadremomtaz, Zeinab Talaei, Hassan Rezai Ghaleno, Mahdi Bagheri, Solomon Habtemariam & Razieh Avan. (2020) Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID‐19. Journal of Clinical Pharmacy and Therapeutics 45:6, pages 1515-1519.
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Sarah Raevens, Sanne Van Campenhout, Pieter-Jan Debacker, Sander Lefere, Xavier Verhelst, Anja Geerts, Hans Van Vlierberghe, Isabelle Colle & Lindsey Devisscher. (2020) Combination of sivelestat and N-acetylcysteine alleviates the inflammatory response and exceeds standard treatment for acetaminophen-induced liver injury. Journal of Leukocyte Biology 107:2, pages 341-355.
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Chika Maki, Yoshiaki Inoue, Tadashi Ishihara, Yohei Hirano, Yutaka Kondo, Koichiro Sueyoshi, Ken Okamoto & Hiroshi Tanaka. (2019) Evaluation of appropriate indications for the use of sivelestat sodium in acute respiratory distress syndrome: a retrospective cohort study. Acute Medicine & Surgery 7:1.
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Shi-Yu Liu, Hao Xiong, Rong-Rong Li, Wen-Chao Yang & Guang-Fu Yang. (2019) Activity-Based Near-Infrared Fluorogenic Probe for Enabling in Vitro and in Vivo Profiling of Neutrophil Elastase. Analytical Chemistry 91:6, pages 3877-3884.
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Kiran Kumar Bali & Rohini Kuner. (2017) Therapeutic potential for leukocyte elastase in chronic pain states harboring a neuropathic component. Pain 158:11, pages 2243-2258.
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Eva Polverino, Edmundo Rosales-Mayor, Glenn E. Dale, Klaus Dembowsky & Antoni Torres. (2017) The Role of Neutrophil Elastase Inhibitors in Lung Diseases. Chest 152:2, pages 249-262.
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Takashi Kido, Keiji Muramatsu, Kazuhiro Yatera, Takeshi Asakawa, Hiroki Otsubo, Tatsuhiko Kubo, Yoshihisa Fujino, Shinya Matsuda, Toshihiko Mayumi & Hiroshi Mukae. (2017) Efficacy of early sivelestat administration on acute lung injury and acute respiratory distress syndrome. Respirology 22:4, pages 708-713.
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Jesús F. Bermejo-Martin, David Andaluz-Ojeda, Raquel Almansa, Francisco Gandía, Jose Ignacio Gómez-Herreras, Esther Gomez-Sanchez, María Heredia-Rodríguez, Jose Maria Eiros, David J. Kelvin & Eduardo Tamayo. (2016) Defining immunological dysfunction in sepsis: A requisite tool for precision medicine. Journal of Infection 72:5, pages 525-536.
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Franz von Nussbaum & Volkhart M.-J. Li. (2015) Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores. Bioorganic & Medicinal Chemistry Letters 25:20, pages 4370-4381.
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KAI-LING JIANG, PENG-PENG MA, XIAO-QUN YANG, LIANG ZHONG, HUI WANG, XIN-YU ZHU & BEI-ZHONG LIU. (2015) Neutrophil elastase and its therapeutic effect on leukemia cells. Molecular Medicine Reports 12:3, pages 4165-4172.
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Joanna L. Giles, Ernest Choy, Carmen van den Berg, B. Paul Morgan & Claire L. Harris. (2015) Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis. The Journal of Immunology 194:7, pages 3029-3034.
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Hermann AM Mucke. (2015) Patent Highlights. Pharmaceutical Patent Analyst 4:1, pages 9-15.
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Takashi Tagami, Ryoichi Tosa, Mariko Omura, Hidetada Fukushima, Tadashi Kaneko, Tomoyuki Endo, Hiroshi Rinka, Akira Murai, Junko Yamaguchi, Kazuhide Yoshikawa, Nobuyuki Saito, Hideaki Uzu, Yoichi Kase, Makoto Takatori, Hiroo Izumino, Toshiaki Nakamura, Ryutarou Seo, Yasuhide Kitazawa, Manabu Sugita, Hiroyuki Takahashi, Yuichi Kuroki, Takayuki Irahara, Takashi Kanemura, Hiroyuki Yokota & Shigeki Kushimoto. (2014) Effect of a selective neutrophil elastase inhibitor on mortality and ventilator-free days in patients with increased extravascular lung water: a post hoc analysis of the PiCCO Pulmonary Edema Study. Journal of Intensive Care 2:1.
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Li-Fu Li, Yi-Ting Lai, Chih-Hao Chang, Meng-Chih Lin, Yung-Yang Liu, Kuo-Chin Kao & Ying-Huang Tsai. (2014) Neutrophil elastase inhibitor reduces ventilation-induced lung injury via nuclear factor-κB and NF-κB repressing factor in mice. Experimental Biology and Medicine 239:8, pages 1045-1057.
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Peter A. Henriksen. (2014) The potential of neutrophil elastase inhibitors as anti-inflammatory therapies. Current Opinion in Hematology 21:1, pages 23-28.
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