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Review

Open-source approaches for the repurposing of existing or failed candidate drugs: learning from and applying the lessons across diseases

Pages 753-766 | Published online: 08 Aug 2013

Keep up to date with the latest research on this topic with citation updates for this article.

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Nagaraj B. S.Krishnan Namboori P. K.Krishna Swaroop Akey, Sathianarayanan Sankaran, Rajesh Kumar Raman, Jawahar Natarajan & Jubie Selvaraj. (2023) Vitamin D analog calcitriol for breast cancer therapy; an integrated drug discovery approach. Journal of Biomolecular Structure and Dynamics 41:20, pages 11017-11043.
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Kathleen L. Miller, Selma Kraft, Abraham Ipe & Lewis Fermaglich. (2021) Drugs and biologics receiving FDA orphan drug designation: an analysis of the most frequently designated products and their repositioning strategies. Expert Opinion on Orphan Drugs 9:11-12, pages 265-272.
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Carolina L. Bellera, Manuel Llanos, Melisa E. Gantner, Santiago Rodriguez, Luciana Gavernet, Marcelo Comini & Alan Talevi. (2021) Can drug repurposing strategies be the solution to the COVID-19 crisis?. Expert Opinion on Drug Discovery 16:6, pages 605-612.
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Alan Talevi & Carolina L. Bellera. (2020) Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics. Expert Opinion on Drug Discovery 15:4, pages 397-401.
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Minna Allarakhia. (2014) The successes and challenges of open-source biopharmaceutical innovation. Expert Opinion on Drug Discovery 9:5, pages 459-465.
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Ghanshyam Parmar, Jay Mukesh Chudasama, Ashish Shah & Ashish Patel. 2023. CADD and Informatics in Drug Discovery. CADD and Informatics in Drug Discovery 253 281 .
Ka Heng Wong, Chie-Min Lim, Ashley Jia Wen Yip, Isra Ahmad Farouk, Nur Zawanah Zabidi, Zheng Yao Low & Sunil K. Lal. 2023. Drug Repurposing for Emerging Infectious Diseases and Cancer. Drug Repurposing for Emerging Infectious Diseases and Cancer 423 450 .
Nithya Krishnamurthy, Alyssa A. Grimshaw, Sydney A. Axson, Sung Hee Choe & Jennifer E. Miller. (2022) Drug repurposing: a systematic review on root causes, barriers and facilitators. BMC Health Services Research 22:1.
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Priscila C. Albuquerque, Fabio Zicker & Bruna P. Fonseca. (2022) Advancing drug repurposing research: Trends, collaborative networks, innovation and knowledge leaders. Drug Discovery Today 27:12, pages 103396.
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Pratik R. AherRushikesh V. AherTejas S. AhireMonali B. PatilHitesh V. ShahareShweta S. Gedam. (2022) Repurposing of Drugs: Updates and New Perspectives. Research Journal of Pharmacy and Technology, pages 4309-4314.
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Guojun Sun, Dashun Dong, Zuojun Dong, Qian Zhang, Hui Fang, Chaojun Wang, Shaoya Zhang, Shuaijun Wu, Yichen Dong & Yuehua Wan. (2022) Drug repositioning: A bibliometric analysis. Frontiers in Pharmacology 13.
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Lucía Pérez-Regidor, Joan Guzmán-Caldentey, Nils Oberhauser, Carmen Punzón, Balázs Balogh, José R. Pedro, Eva Falomir, Alessandra Nurisso, Péter Mátyus, J. Carlos Menéndez, Belén de Andrés, Manuel Fresno & Sonsoles Martín-Santamaría. (2022) Small Molecules as Toll-like Receptor 4 Modulators Drug and In-House Computational Repurposing. Biomedicines 10:9, pages 2326.
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Sushil Kumar Middha, Talambedu Usha, Shivani Sukhralia, Charu Pareek, Ritu Yadav, Rupal Agnihotri, Javeriya Tasneem, Arvind Kumar Goyal & Dinesh Babu. 2022. Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV-2 Infection. Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV-2 Infection 519 536 .
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Marvin Hanisch & Bastian Rake. (2021) Repurposing without purpose? Early innovation responses to the COVID‐19 crisis: Evidence from clinical trials. R&D Management 51:4, pages 393-409.
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Supriya Roy, Suneela Dhaneshwar & Bhavya Bhasin. (2021) Drug Repurposing: An Emerging Tool for Drug Reuse, Recycling and Discovery. Current Drug Research Reviews 13:2, pages 101-119.
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Talambedu Usha, Sushil K. Middha, Anusha A. Kukanur, Rachamadugu V. Shravani, Mahantesh N. Anupama, Nagasamudram Harshitha, Ameena Rahamath, Sumedha S. Kulkarni & Arvind K. Goyal. (2021) Drug Repurposing Approaches: Existing Leads for Novel Threats and Drug Targets. Current Protein & Peptide Science 22:3, pages 251-271.
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Hema Sree GNS, Saraswathy GR, Manikanta Murahari & Mamatha Krishnamurthy. (2019) An update on Drug Repurposing: Re-written saga of the drug’s fate. Biomedicine & Pharmacotherapy 110, pages 700-716.
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Tran-Thai Dang, Phetnidda Ouankhamchan & Tu-Bao Ho. (2016) Detection of new drug indications from electronic medical records. Detection of new drug indications from electronic medical records.
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Peter J. Barnes, Sergio Bonini, Werner Seeger, Maria G. Belvisi, Brian Ward & Anthony Holmes. (2015) Barriers to new drug development in respiratory disease. European Respiratory Journal 45:5, pages 1197-1207.
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