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Review

Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations

Pages 103-125 | Published online: 17 Dec 2014

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Fiorenza Stagni, Andrea Giacomini, Marco Emili, Sandra Guidi, Elisabetta Ciani & Renata Bartesaghi. (2017) Epigallocatechin gallate: A useful therapy for cognitive disability in Down syndrome?. Neurogenesis 4:1.
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Cassia Overk & William C. Mobley. 2023. Neurobiology of Brain Disorders. Neurobiology of Brain Disorders 45 68 .
Yang Du, Ya-Juan Zhu, Yi-Xin Zhou, Jing Ding & Ji-Yan Liu. (2022) Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study. Molecular Biomedicine 3:1.
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Carmen Martínez-Cué & Renata Bartesaghi. (2022) Fatty Acids: A Safe Tool for Improving Neurodevelopmental Alterations in Down Syndrome?. Nutrients 14:14, pages 2880.
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Fiorenza Stagni & Renata Bartesaghi. (2022) The Challenging Pathway of Treatment for Neurogenesis Impairment in Down Syndrome: Achievements and Perspectives. Frontiers in Cellular Neuroscience 16.
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Bani Bandana Ganguly. 2022. Genetics and Neurobiology of Down Syndrome. Genetics and Neurobiology of Down Syndrome 405 464 .
Angela John Thurman, Jamie O. Edgin, Stephanie L. Sherman, Audra Sterling, Andrea McDuffie, Elizabeth Berry-Kravis, Debra Hamilton & Leonard Abbeduto. (2021) Spoken language outcome measures for treatment studies in Down syndrome: feasibility, practice effects, test-retest reliability, and construct validity of variables generated from expressive language sampling. Journal of Neurodevelopmental Disorders 13:1.
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Md. Mahiuddin Ahmed, Aaron Block, Nicolas Busquet & Katheleen J. Gardiner. (2021) Context Fear Conditioning in Down Syndrome Mouse Models: Effects of Trisomic Gene Content, Age, Sex and Genetic Background. Genes 12:10, pages 1528.
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Md. Mahiuddin Ahmed, Noah R. Johnson, Timothy D. Boyd, Christina Coughlan, Heidi J. Chial & Huntington Potter. (2021) Innate Immune System Activation and Neuroinflammation in Down Syndrome and Neurodegeneration: Therapeutic Targets or Partners?. Frontiers in Aging Neuroscience 13.
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Angelika Buczyńska, Iwona Sidorkiewicz, Anna Trochimiuk, Sławomir Ławicki, Adam Jacek Krętowski & Monika Zbucka-Krętowska. (2021) Novel Approaches to an Integrated Route for Trisomy 21 Evaluation. Biomolecules 11:9, pages 1328.
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Angelika Buczyńska, Iwona Sidorkiewicz, Sławomir Ławicki, Adam Jacek Krętowski & Monika Zbucka-Krętowska. (2021) Prenatal Screening of Trisomy 21: Could Oxidative Stress Markers Play a Role?. Journal of Clinical Medicine 10:11, pages 2382.
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Verónica Vidal, Alba Puente, Susana García-Cerro, María Teresa García Unzueta, Noemí Rueda, Javier Riancho & Carmen Martínez-Cué. (2021) Bexarotene Impairs Cognition and Produces Hypothyroidism in a Mouse Model of Down Syndrome and Alzheimer’s Disease. Frontiers in Pharmacology 12.
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Laszlo Pecze, Elisa B. Randi & Csaba Szabo. (2020) Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudohypoxic state in Down syndrome. Molecular Medicine 26:1.
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Faycal Guedj, Ashley E. Siegel, Jeroen L.A. Pennings, Fatimah Alsebaa, Lauren J. Massingham, Umadevi Tantravahi & Diana W. Bianchi. (2020) Apigenin as a Candidate Prenatal Treatment for Trisomy 21: Effects in Human Amniocytes and the Ts1Cje Mouse Model. The American Journal of Human Genetics 107:5, pages 911-931.
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Noemí Rueda, Verónica Vidal, Susana García-Cerro, Alba Puente, Víctor Campa, Sara Lantigua, Oriol Narcís, Renata Bartesaghi & Carmen Martínez-Cué. (2020) Prenatal, but not Postnatal, Curcumin Administration Rescues Neuromorphological and Cognitive Alterations in Ts65Dn Down Syndrome Mice. The Journal of Nutrition 150:9, pages 2478-2489.
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Yuchen Gu, Gautier Moroy, Jean-Louis Paul, Anne-Sophie Rebillat, Mara Dierssen, Rafael de la Torre, Cécile Cieuta-Walti, Julien Dairou & Nathalie Janel. (2020) Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup® Dietary Supplement: Role of Green Tea Catechins. International Journal of Molecular Sciences 21:4, pages 1404.
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Patricia R. Shaw, Jenny A. Klein, Nadine M. Aziz & Tarik F. Haydar. (2020) Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of Down syndrome. Disease Models & Mechanisms.
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Laura Reiche, Patrick Küry & Peter Göttle. (2019) Aberrant Oligodendrogenesis in Down Syndrome: Shift in Gliogenesis?. Cells 8:12, pages 1591.
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Nunzia Mollo, Maria Nitti, Lucrezia Zerillo, Deriggio Faicchia, Teresa Micillo, Rossella Accarino, Agnese Secondo, Tiziana Petrozziello, Gaetano Calì, Rita Cicatiello, Ferdinando Bonfiglio, Viviana Sarnataro, Rita Genesio, Antonella Izzo, Paolo Pinton, Giuseppe Matarese, Simona Paladino, Anna Conti & Lucio Nitsch. (2019) Pioglitazone Improves Mitochondrial Organization and Bioenergetics in Down Syndrome Cells. Frontiers in Genetics 10.
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J. C. Lauterborn, M. N. Schultz, A. A. Le, M. Amani, A. E. Friedman, P. T. Leach, C. M. Gall, G. S. Lynch & J. N. Crawley. (2019) Spaced training improves learning in Ts65Dn and Ube3a mouse models of intellectual disabilities. Translational Psychiatry 9:1.
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Alba Navarro-Romero, Anna Vázquez-Oliver, Maria Gomis-González, Carlos Garzón-Montesinos, Rafael Falcón-Moya, Antoni Pastor, Elena Martín-García, Nieves Pizarro, Arnau Busquets-Garcia, Jean-Michel Revest, Pier-Vincenzo Piazza, Fátima Bosch, Mara Dierssen, Rafael de la Torre, Antonio Rodríguez-Moreno, Rafael Maldonado & Andrés Ozaita. (2019) Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome. Neurobiology of Disease 125, pages 92-106.
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Handan Kulan & Tamer Dağ. (2019) Analysis of Rescued Learning with Different Drugs in down Syndrome. International Journal of Bioscience, Biochemistry and Bioinformatics 9:3, pages 173-179.
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Anis Feki & Youssef Hibaoui. (2018) DYRK1A Protein, A Promising Therapeutic Target to Improve Cognitive Deficits in Down Syndrome. Brain Sciences 8:10, pages 187.
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Guido N. Vacano, David S. Gibson, Abdullah Arif Turjoman, Jeremy W. Gawryluk, Jonathan D. Geiger, Mark Duncan & David Patterson. (2018) Proteomic analysis of six- and twelve-month hippocampus and cerebellum in a murine Down syndrome model. Neurobiology of Aging 63, pages 96-109.
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Gaëlle Naert, Valentine Ferré, Emeline Keller, Amy Slender, Dorota Gibbins, Elizabeth MC Fisher, Victor LJ Tybulewicz & Tangui Maurice. (2017) In vivo and ex vivo analyses of amyloid toxicity in the Tc1 mouse model of Down syndrome. Journal of Psychopharmacology 32:2, pages 174-190.
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A. Block, Md.M. Ahmed, N. Rueda, M.-C. Hernandez, C. Martinez-Cué & K.J. Gardiner. (2018) The GABA A α5-selective Modulator, RO4938581, Rescues Protein Anomalies in the Ts65Dn Mouse Model of Down Syndrome. Neuroscience 372, pages 192-212.
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E.J.T. Verweij & D. Oepkes. 2018. Noninvasive Prenatal Testing (NIPT). Noninvasive Prenatal Testing (NIPT) 353 367 .
Martina Parrini, Diego Ghezzi, Gabriele Deidda, Lucian Medrihan, Enrico Castroflorio, Micol Alberti, Pietro Baldelli, Laura Cancedda & Andrea Contestabile. (2017) Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome. Scientific Reports 7:1.
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Md. Mahiuddin Ahmed, Aaron Block, Suhong Tong, Muriel T. Davisson & Katheleen J. Gardiner. (2017) Age exacerbates abnormal protein expression in a mouse model of Down syndrome. Neurobiology of Aging 57, pages 120-132.
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Susan Helm, Morgan Blayney, Taylor Whited, Mahjabin Noroozi, Sen Lin, Semira Kern, David Green & Ahmad Salehi. (2017) Deleterious Effects of Chronic Folate Deficiency in the Ts65Dn Mouse Model of Down Syndrome. Frontiers in Cellular Neuroscience 11.
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Andrea Contestabile, Salvatore Magara & Laura Cancedda. (2017) The GABAergic Hypothesis for Cognitive Disabilities in Down Syndrome. Frontiers in Cellular Neuroscience 11.
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James C. Harris. (2017) Advances in developmental neuropsychiatry. Current Opinion in Psychiatry 30:2, pages 65-68.
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Moushira E. Zaki, Hala T. El-Bassyouni, Angie M.S. Tosson, Eman Youness & Jihan Hussein. (2017) Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects. Jornal de Pediatria (Versão em Português) 93:1, pages 100-104.
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Moushira E. Zaki, Hala T. El-Bassyouni, Angie M.S. Tosson, Eman Youness & Jihan Hussein. (2017) Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects. Jornal de Pediatria 93:1, pages 100-104.
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Meenal Gupta, A. Ranjitha Dhanasekaran & Katheleen J. Gardiner. (2016) Mouse models of Down syndrome: gene content and consequences. Mammalian Genome 27:11-12, pages 538-555.
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Ramón Pérez-Núñez, Natalia Barraza, Arlek Gonzalez-Jamett, Ana Maria Cárdenas, Jean-Vianney Barnier & Pablo Caviedes. (2016) Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome: Consequences on Cell Process Formation and Extension. Neurotoxicity Research 30:1, pages 76-87.
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Aaron Block, Md. Mahiuddin Ahmed, A. Ranjitha Dhanasekaran, Suhong Tong & Katheleen J. Gardiner. (2015) Sex differences in protein expression in the mouse brain and their perturbations in a model of Down syndrome. Biology of Sex Differences 6:1.
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Fiorenza Stagni, Andrea Giacomini, Sandra Guidi, Elisabetta Ciani & Renata Bartesaghi. (2015) Timing of therapies for Down syndrome: the sooner, the better. Frontiers in Behavioral Neuroscience 9.
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Clara Higuera, Katheleen J. Gardiner & Krzysztof J. Cios. (2015) Self-Organizing Feature Maps Identify Proteins Critical to Learning in a Mouse Model of Down Syndrome. PLOS ONE 10:6, pages e0129126.
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Md. Mahiuddin Ahmed, A. Ranjitha Dhanasekaran, Aaron Block, Suhong Tong, Alberto C. S. Costa, Melissa Stasko & Katheleen J. Gardiner. (2015) Protein Dynamics Associated with Failed and Rescued Learning in the Ts65Dn Mouse Model of Down Syndrome. PLOS ONE 10:3, pages e0119491.
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